Ischemic Brain Damage and Single Quantum Sodium MRI

缺血性脑损伤和单量子钠 MRI

基本信息

批准号：
9926325
负责人：
Fernando E Boada
金额：
$ 57.15万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9926325
关键词：
Acute Animal Model Biological Markers Brain Brain Ischemia Brain scan Cause of Death Clinical Clinical Trials Coagulation Process Containment Country Development Diffusion Magnetic Resonance Imaging Effectiveness Eligibility Determination Enrollment Evolution Excision Exclusion Funding Goals Guidelines Human Imaging Techniques Infarction Injury Institution Intervention Ischemic Brain Injury Laboratories Lead Life MRI Scans Magnetic Resonance Imaging Measures Metabolic Middle Cerebral Artery Occlusion Modeling New York Observational Study Outcome Patients Perfusion Procedures Protons Reperfusion Therapy Research Personnel Risk Role Services Sodium Stroke Study Subject Testing Therapeutic Time Tissue Viability Tissues United States Universities Work acute stroke base brain tissue clinical heterogeneity diffusion weighted disability disease heterogeneity follow-up human subject improved outcome inclusion criteria ischemic injury medical schools nonhuman primate novel quantum stroke patient stroke therapy success tissue biomarkers tool

项目摘要

PROJECT SUMMARY This proposal seeks to evaluate the role of tissue sodium concentration (TSC), as measured by magnetic resonance imaging (MRI), on the acute management of brain ischemia. To achieve this goal, we will perform MRI scans within 20 minutes of recanalization therapy on acute stroke patients treated in the Interventional Neuroradiology service at the New York University School of Medicine (NYUSOM). Our underlying hypothesis is that brain tissue with a TSC above 65mM represents non-viable tissue and, therefore, will not recover upon reperfusion therapy of any type. This hypothesis was borne out from observations during our previous work on serial MR imaging during reversible middle cerebral artery occlusion of non-human primates. This hypothesis will be tested by comparing the spatially co-registered volume of critically elevated TSC (above 65mM) after recanalization and the volume of infarction (on the 30 day follow up) on the brain of each study subject. We plan to enroll a total of 120 subjects during this five-year proposal in order to account for the heterogeneity of the disease while still attaining the required statistical significance.

项目摘要该提案旨在评估组织钠浓度（TSC）的作用，如磁共振成像（MRI），关于脑缺血的急性管理。为了实现这一目标，我们将执行 MRI扫描在介入治疗的急性中风患者后20分钟内纽约大学医学院（NYUSOM）的神经放射学服务。我们的基本假设 TSC高于65mm的脑组织代表不可行的组织，因此不会在任何类型的再灌注疗法。在我们以前的工作中，这一假设是从观察中得出的非人类灵长类动物的可逆性脑动脉闭塞过程中的串行MR成像。这个假设将通过比较在空间共同注册的TSC（65mm以上）的空间共注册体积每个研究受试者的大脑的重新定性和梗塞的体积（在30天后进行）。我们计划在此五年提案中总共注册120名受试者，以说明该疾病在仍达到所需的统计意义的同时。