University of Pittsburgh HIV-Comorbidities Research Training Program in South Africa

南非匹兹堡大学艾滋病毒合并症研究培训项目

基本信息

批准号：
9923781
负责人：
JEAN BISIMWA NACHEGA
金额：
$ 29.98万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-30 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9923781
关键词：
Active Learning Address Advisory Committees Africa South of the Sahara Aging Caliber California Cardiovascular Diseases Chronic Kidney Failure Clinical Consultations Country Development Plans Doctor of Philosophy Educational workshop Ethics Evaluation Frequencies HIV Health Policy Individual Inflammation Institution Journals Knowledge Leadership Life Expectancy Life Style Los Angeles Mentors Modeling Monitor Outcome Population Prevention strategy Public Health Research Research Ethics Research Methodology Research Personnel Research Project Grants Research Training Resources San Francisco Seeds South Africa South African Testing Time Toxic effect Training Training Programs Translating Universities Writing antiretroviral therapy career development clinical practice comorbidity cost effectiveness design effectiveness evaluation experience high risk improved outcome innovation mortality multiple chronic conditions neuropsychiatric disorder next generation programs recruit skills treatment strategy web site

项目摘要

Although the life expectancy of HIV-infected individuals increases with effective antiretroviral therapy (ART) use, they remain at higher risk of multi-morbidity and mortality than the general HIV-uninfected population. Long-term ART-related toxicity, persistent inflammation, and lifestyle have been hypothesized as mechanisms for non-AIDS defined conditions such as cardiovascular disease (CVD), chronic kidney diseases (CKD), and neuropsychiatric disease (NPD), which are increasing in frequency with the aging of the HIV-infected population. Very little research has been conducted to quantify the burden of these three HIV-comorbidities or to design and evaluate the effectiveness and cost-effectiveness of preventive and treatment strategies in sub-Saharan Africa. Moreover, South Africa, the country with the highest burden of HIV globally, unfortunately has a paucity of qualified investigators to effect change in these HIV-comorbidities. The overall objective of the University of Pittsburgh HIV-comorbidities Research Training Program in South Africa (Pitt-HRTP-SA) is to build a critical mass of the next generation of basic, translational, clinical, and public health researchers at Stellenbosch University in Cape Town, to conduct high-quality research, generate new knowledge, improve outcomes, and become successful, independent investigators. The specific aims are: 1) To gain research methodology, ethics, leadership and management skills; 2) To conduct mentored HIV-CVD, CKD, and NPD research that address new, locally relevant questions and test meaningful hypotheses; 3) To become proficient in scientific presentations and writing, grantsmanship, research ethics and management; 4) To evaluate the outcomes of the program and make adjustments as needed and acquire skills to translate research findings into clinical practice and public health policies. We will achieve these aims using an innovative North-South and South- South triangular mentoring model. Each trainee will have one South African core mentor (affiliated with SU or University of Cape Town) and one US co-mentor (University of Pittsburgh; Johns Hopkins University; Harvard University; University of California, San Francisco; University of California, Los Angeles), short- term training experience at one of the collaborating US institutions. The strategies utilized to build and enhance research capacity will include: didactic coursework (Masters and/or PhD), mentored high-caliber research, experiential learning, pilot research grants, workshops, seminars, journal clubs, scientific writing retreats, and Pitt-HRTP-SA website resources. A Steering Committee, after consultation with an independent Training Advisory Committee, will approve the recruitment, research, monitoring, and evaluation of twelve highly competitive trainees, each of whom will be provided a seed research grant and up to 50% of protected research time up to 5 years. Each trainee will have an individualized career development plan that will be monitored and tracked throughout their tenure and after completion of the program.

尽管艾滋病毒感染者的预期寿命随着有效的抗逆转录病毒疗法（ART）的使用而增加，与一般未感染艾滋病毒的人群相比，他们仍然面临更高的多种发病率和死亡率的风险。长期 ART 相关毒性、持续性炎症和生活方式被假设为心血管疾病（CVD）、慢性肾病等非艾滋病定义的疾病的机制疾病（CKD）和神经精神疾病（NPD），这些疾病的发生率随着年龄的增长而增加艾滋病毒感染者的数量。很少有研究来量化这些负担三种艾滋病毒合并症或设计和评估预防措施的有效性和成本效益和撒哈拉以南非洲的治疗策略。此外，南非是死亡率最高的国家。不幸的是，全球艾滋病毒的负担缺乏合格的研究人员来影响这些方面的改变艾滋病毒合并症。匹兹堡大学艾滋病毒合并症研究培训的总体目标南非的计划（Pitt-HRTP-SA）旨在打造下一代基础、开普敦斯泰伦博斯大学的转化、临床和公共卫生研究人员，进行高质量的研究，产生新知识，改善成果，并取得成功，独立调查员。具体目标是： 1）获得研究方法、道德、领导力和管理技能； 2) 开展受指导的 HIV-CVD、CKD 和 NPD 研究，解决新的、本地的问题相关问题并测试有意义的假设； 3) 熟练地进行科学演示写作、资助、研究伦理和管理； 4) 评估结果根据需要进行计划和调整，并获得将研究结果转化为临床的技能实践和公共卫生政策。我们将通过创新的南北合作来实现这些目标南三角辅导模式。每位学员将有一名南非核心导师（隶属于SU 或开普敦大学）和一位美国联合导师（匹兹堡大学、约翰霍普金斯大学、哈佛大学；加州大学旧金山分校；加州大学洛杉矶分校），短- 在美国合作机构之一的学期培训经验。用于构建和增强研究能力将包括：教学课程（硕士和/或博士）、指导的高素质人才研究、体验式学习、试点研究资助、讲习班、研讨会、期刊俱乐部、科学写作静修会和 Pitt-HRTP-SA 网站资源。指导委员会在与独立的培训咨询委员会，将批准招聘、研究、监测和评估十二名极具竞争力的实习生，每人将获得种子研究补助金和高达 50% 受保护的研究时间长达5年。每位学员都会有个性化的职业发展计划将在他们的整个任期内以及该计划完成后对其进行监测和跟踪。