Amygdala and Striatal Neural Circuits Controlling Alcohol Intake

杏仁核和纹状体神经回路控制酒精摄入量

• 批准号: 9922827
• 负责人: Patricia H. Janak
• 金额: $ 36.84万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9922827
• 关键词: Acute; Alcohol consumption; Alcohol dependence; Alcohols; Amygdaloid structure; Animal Behavior; Anxiety; Behavior; Behavioral; Calcium; Cell Nucleus; Chronic; Cognitive; Consummatory Behavior; Consumption; Corpus striatum structure; Cues; Dependence; Desire for food; Economic Burden; Elements; Ethanol; Event; Fiber; Globus Pallidus; Goals; Health; Human; Hypothalamic structure; Image; Individual; Intake; Interruption; Investigation; Lateral; Liquid substance; Measures; Mediating; Mediation; Mediator of activation protein; Motivation; Neurobiology; Neurons; Nucleus Accumbens; Oral; Pathway interactions; Phase; Photometry; Population; Prosencephalon; Rattus; Regulation; Relapse; Rewards; Role; Self Administration; Specific qualifier value; Stimulus; Study models; Technology; Testing; Thalamic structure; United States; Work; addiction; alcohol abuse therapy; alcohol use disorder; behavior measurement; binge drinking; design; drinking; drinking behavior; feeding; in vivo; in vivo calcium imaging; neural circuit; neuroadaptation; neurobiological mechanism; novel therapeutics; optogenetics; prevent; recruit; relating to nervous system; social

Project Summary/Abstract While considerable effort has been focused upon the neurobiological circuits mediating appetitive, or reward seeking, aspects on alcohol self-administration, our understanding of the circuits that mediate the consummatory aspects – the actual alcohol intake itself – is more limited. Therefore, the studies proposed in this application seek to define the neural circuits that control alcohol intake. These studies build on past work supporting a role for the nucleus accumbens and the amygdala central nucleus both in both natural feeding and in alcohol intake. The contribution of these regions and selected afferents and efferents will be determined using optogenetics to activate or suppress neuronal populations or specific neural projections, and using calcium imaging to query the activity of these neural elements, during cue-elicited and spontaneous alcohol intake. In addition, these studies will examine the impact of prior alcohol dependence on the role of the accumbens and the amygdala central nucleus given the strong evidence for alcohol- induced neuroadaptations in these extended amygdala regions. These studies represent important steps towards specification of consummatory circuits whose function may change after chronic alcohol representing a possible neurobiological mediator of excessive or escalated alcohol intake.

项目摘要/摘要 虽然大量努力集中在介导食欲或奖励的神经生物学电路上 寻求酒精自给自足的方面，我们对介导的电路的理解 完整的方面 - 实际酒精摄入本身 - 更有限制。因此，研究提出了 在此应用中，旨在定义控制酒精摄入的神经回路。这些研究以过去为基础 支持伏隔核和杏仁核中央核的作用，既有天然 进食和酒精摄入量。这些地区以及选定的传入和效果的贡献将是 使用光遗传学来激活或抑制神经元种群或特定的神经元投影， 并使用钙成像查询这些神经元元素的活性，在提示引用和 自发酒精摄入。此外，这些研究将检查先前酒精依赖的影响 关于伏隔和杏仁核中央核的作用，有强有力的证据证明了酒精 在这些扩展的杏仁核区域中诱导的神经加热。这些研究代表了重要步骤 朝着慢性酒精后的功能可能变化的完整电路规定 代表过量或升级的酒精摄入量的可能的神经生物学介质。