1Florida Alzheimer's Disease Research Center Neuropathology Core

1佛罗里达阿尔茨海默病研究中心神经病理学核心

• 批准号: 9921605
• 负责人: Stefan Prokop
• 金额: $ 22.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9921605
• 关键词: Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease pathology; Alzheimer' s disease patient; Amyloid; Archives; Autopsy; Biological Markers; Brain; Cerebrospinal Fluid; Clinical; Clinical Research; Cognitive; Consensus; Consent; Consultations; DNA; Data; Databases; Diagnosis; Diagnostic; Disease; Disease Progression; Ensure; Evaluation; Experimental Designs; Freezing; Frontotemporal Lobar Degenerations; Gene Mutation; Goals; Gold; Guidelines; Human; Individual; Lewy Bodies; National Institute on Aging; Needs Assessment; Nerve Degeneration; Nervous system structure; Neuraxis; Neurodegenerative Disorders; Neurofibrillary Tangles; Onset of illness; Pathologic; Pathology; Patients; Plasma; Procedures; Proteins; Research; Research Personnel; Research Support; Resources; Sampling; Senile Plaques; Serum; Testing; Tissues; Training Activity; base; clinical Diagnosis; cohort; data management; education research; genetic risk factor; mouse model; neuropathology; patient subsets; protein TDP-43; protein aggregation; response; symposium; tau Proteins

In order to support the goals of the 1Florida Alzheimer’s Disease Research Center (1Florida ADRC) the Neuropathology Core will perform diagnostic evaluations and quantitative analyses of the brains collected from deceased individuals that participate in the clinical studies. A definite diagnosis of AD still requires a thorough post-mortem evaluation. We will coordinate storage of biospecimens including blood plasma, serum, DNA, and CSF and their distribution in response to request from qualified investigators inside and outside the 1Florida ADRC. The specific aims of the Neuropathology Core are: Aim 1 Conduct a thorough post-mortem CNS examination in accordance to National Institute on Aging-Alzheimer’s Association consensus guidelines of ~25 ADRC subjects/year followed longitudinally in the Clinical Core with consent and establish a neuropathological diagnosis for each patient. Aim 2 Provide neuropathologic data to be included in the database using support from the Data Management and Statistical (DMS) Core and provide ADRC data in concert with the Clinical Core. Neuropathological data will be provided to the National Alzheimer Coordinating Center (NACC) through the Data Management and Statistical Core Aim 3 Collect and maintain a bank of archived unfixed frozen and fixed tissue, DNA, cerebrospinal fluid (CSF), serum and plasma from ADRC patients with AD, MCI, preMCI or other related neurodegenerative diseases, along with CN controls and distribute these samples to qualified investigators within the ADRC and external investigators upon request. Aim 4 Be responsive to changing needs in tissue acquisition and processing to support new scientific studies and provide consultation regrading appropriate experimental design for neuropathology studies in both human samples and mouse models of various inclusion pathologies relevant to neurodegenerative disorders. Aim 5 Execute clinical pathologic case conferences, brain cutting and other activities supporting research training activities and ensure integration with other Cores within the 1Florida ADRC. Final diagnoses will be achieved by clinical-pathological consensus conferences to be held quarterly with the Clinical Core, which will serve as an important educational component that will integrate with the Research Education Component. These activities of this Core are all critical functions of an ADRC.

为了支持1florida阿尔茨海默氏病研究中心（1florida adrc）的目标 神经病理学核心将对从中收集的大脑进行诊断评估和定量分析 参加临床研究的已故个人。定义的AD诊断仍然需要彻底 验尸评估。我们将协调包括血浆，血清，DNA和 CSF及其分配，以应对1florida内外合格的调查人员的要求 ADRC。神经病理学核心的具体目的是：AIM 1进行彻底的验尸中心 根据美国国家老化 - 阿尔茨海默氏症协会共识指南的审查〜25 ADRC受试者/年在临床核心纵向遵循并建立神经病理学 每个患者的诊断。 AIM 2提供使用支持的神经病理学数据将包含在数据库中 来自数据管理和统计（DMS）核心，并与临床一起提供ADRC数据 核。神经病理学数据将通过通过 数据管理和统计核心AIM 3收集并维护了一堆存档的未固定冷冻和 固定组织，DNA，脑脊液（CSF），ADRC患者AD，MCI，PERMCI或ADRC患者的血清和血浆 其他相关的神经退行性疾病，以及CN对照，并将这些样品分配给合格 ADRC中的调查人员和外部调查人员应要求。目标4响应不断变化的需求 在组织获取和处理方面支持新的科学研究并提供咨询 适用于人类样品和小鼠模型的神经病理学研究的适当实验设计 与神经退行性疾病有关的各种纳入病理。 AIM 5执行临床病理病例 会议，切割和其他支持研究培训活动的活动，并确保与 1florida adrc中的其他核心。最终诊断将通过临床病理共识来实现 每季度将以临床核心举行会议，该会议将作为重要的教育组成部分 这将与研究教育部分集成。这些核心的这些活动都是关键功能 ADRC。