HMS/CHB Center for Neuroscience Research

HMS/CHB 神经科学研究中心

基本信息

批准号：
8733766
负责人：
MICHAEL ELDON GREENBERG
金额：
$ 76.64万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-30 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8733766
关键词：
Adopted Architecture Area Boston Brain Cellular Morphology Cellular Structures Center Core Grants Cognition Collaborations Communities Core Facility Development Education Ensure Environment Equipment Fees Fluorescence Microscopy Fostering Functional disorder Funding Future Gap Junctions Glues Goals Image Imaging Techniques Immunohistochemistry Individual Institution Knowledge Laboratories Learning Disorders Medical Mental disorders Methodology Microscopy Mission Modeling Molecular Monitor National Institute of Neurological Disorders and Stroke Nerve Degeneration Neurobiology Neurosciences Neurosciences Research Optics Pediatric Hospitals Postdoctoral Fellow Process Productivity Recording of previous events Reliance Research Research Personnel Resolution Resources Services Structure Sum Synapses Technology Tissue Sample Training base cellular imaging cost effective design frontier graduate student innovation medical schools molecular imaging nervous system development nervous system disorder neural circuit new technology novel therapeutics programs reconstruction relating to nervous system tomography tool treatment strategy

项目摘要

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research, we propose to establish an innovative Neural Imaging Center composed of four Core facilities that will serve NINDS-funded Harvard Medical School (HMS) and Children's Hospital Boston (CHB) investigators. These state-of-the-art facilities will provide important new resources to the HMS and CHB neuroscience community, and will perform essential services that are difficult and impractical for individual laboratories to provide on ther own. The Imaging Center will be composed of an Administrative Core, a High-Content Cellular Imaging Core, an immunohistochemistry-based Array Tomography Core, and a Super-resolution Imaging Core. The experimental opportunities and innovative services provided by the Imaging Center will give area neuroscientists access to unique equipment and training in several new cutting-edge methodologies, greatly benefiting the research programs of NINDS-funded investigators at these institutions. Moreover, the Center will function as the centerpiece of a concerted effort to strengthen ties between the neuroscience communities at HMS and CHB. Thus, a major focus of this Center will be to serve as a nexus for collaborative interactions. To this end, we propose not only to establish a set of core facilities, but also to adopt several strategies that reduce the barriers to their widespread utilization, including provisions for informal education regarding core methodologies and significant technical support. Through the development of this Center, we hope to shift from a complete reliance on individual laboratory-centered research to a more cost-effective and productive use of extraordinary cores while further deepening existing ties between these two vibrant neuroscience communities. RELEVANCE: We propose to establish a Neural Imaging Center to serve NINDS-funded Harvard Medical School and Children's Hospital Boston investigators. These facilities will provide important new resources and perform essential services that are difficult and impractical for individual laboratories to perform on their own, thereby accelerating the pace of neuroscience research at these institutions.

描述（由申请人提供）：在支持神经科学研究的机构中心核心拨款中，我们建议建立一个由四个核心设施组成的创新神经影像中心，该中心将为 NINDS 资助的哈佛医学院 (HMS) 和波士顿儿童医院 (CHB) 提供服务）调查员。这些最先进的设施将为 HMS 和 CHB 神经科学界提供重要的新资源，并将提供单个实验室难以单独提供的基本服务。该成像中心将由一个管理核心、一个高内涵细胞成像核心、一个基于免疫组织化学的阵列断层成像核心和一个超分辨率成像核心组成。成像中心提供的实验机会和创新服务将使该地区的神经科学家能够获得独特的设备和几种新的尖端方法的培训，从而极大地有利于这些机构的 NINDS 资助的研究人员的研究项目。此外，该中心将作为加强 HMS 和 CHB 神经科学界之间联系的共同努力的核心。因此，该中心的主要重点将是充当协作互动的纽带。为此，我们建议不仅要建立一套核心设施，还要采取多项战略来减少其广泛利用的障碍，包括提供有关核心方法的非正式教育和重要的技术支持。通过该中心的发展，我们希望从完全依赖以实验室为中心的个人研究转向以更具成本效益和生产力的方式使用非凡核心，同时进一步加深这两个充满活力的神经科学界之间的现有联系。相关性：我们提议建立一个神经影像中心，为 NINDS 资助的哈佛医学院和波士顿儿童医院的研究人员提供服务。这些设施将提供重要的新资源并提供单个实验室难以独立完成的基本服务，从而加快这些机构神经科学研究的步伐。