Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular health

非持续性化学品接触、胎盘发育和孕产妇孕前和孕后心血管健康

基本信息

批准号：
9917782
负责人：
Linda G Kahn
金额：
$ 11万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-17 至 2021-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9917782
关键词：
Affect Age Angiogenesis Inhibitors Angiogenic Factor Attention Award Biological Biological Markers Birth Birth Weight Blood Pressure Blood Vessels Blood flow Body fat Body mass index Cardiac Output Cardiovascular Diagnostic Techniques Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Cause of Death Chemical Exposure Chemicals Child Child Health Chronic Clinical Complex Data Eclampsia Education Educational workshop Endocrine Disruptors Endothelium Environment Environmental Epidemiology Epidemiologist Exposure to Faculty Fertility Fetal Development Functional disorder Funding Gestational Diabetes Goals Growth Growth and Development function Health Hospitalization Hypertension Impairment Incidence Inflammatory Link Lipids Long-Term Effects Maternal Exposure Maternal and Child Health Measurable Measures Mentorship Methodology Mothers Neonatal Mortality New York Nulliparity Nutrient Organ Outcome PGF gene Participant Pathway interactions Perfusion Phase Physiologic pulse Placenta Placentation Plastics Population Positioning Attribute Postpartum Period Pre-Eclampsia Pregnancy Pregnancy Complications Pregnancy Trimesters Principal Investigator Publishing Questionnaires Reading Research Research Activity Research Personnel Research Project Grants Risk Risk Factors Seminal fluid Serum Statistical Methods Training Training Activity United States Universities Vascular Endothelial Growth Factor Receptor-1 Vascularization Weight Woman Women&apos s Health Work advanced maternal age adverse birth outcomes apprenticeship bisphenol A cardiovascular health cardiovascular risk factor career cohort cytokine design early pregnancy environmental chemical experience fetal follow-up longitudinal analysis maternal serum neonatal morbidity personal care products phthalates post-doctoral training postnatal pregnancy disorder pregnancy hypertension prenatal recruit reproductive reproductive epidemiology reproductive success skills time-to-pregnancy urinary

项目摘要

PROJECT SUMMARY/ABSTRACT In the United States, increasing numbers of women are experiencing pregnancy complications such as preeclampsia, eclampsia, and gestational hypertension that can put their own and their children’s immediate and long-term health at risk. In particular, these hypertensive disorders of pregnancy are associated with increased incidence of postnatal cardiovascular disease in women. The link appears to be the placenta, an organ that both regulates nutrient flow to the developing fetus and influences maternal cardiovascular function. Nonpersistent endocrine disrupting chemicals (EDCs), including bisphenols found in plastics and phthalates found in personal care products, have been associated with cardiovascular disease and may also be associated with placental dysfunction. Over the course of my masters, doctoral, and postdoctoral training, I have begun to develop a portfolio of published research in both environmental and reproductive epidemiology, with a particular emphasis on identifying underlying biological mechanisms. My prior education and experience positions me well to undertake my proposed K99/R00 research project: examining relations among maternal exposure to nonpersistent EDCs, biomarkers of placental dysfunction, and indicators of maternal cardiovascular disease both before and after pregnancy. This Pathway to Independence Award will provide the additional mentorship and expertise I need to transition to faculty and successfully compete for funding as a principal investigator. My training plan includes formal courses, workshops and seminars, directed readings, and apprenticeships to develop skills in 1) EDCs, environmental epidemiology, and exposure assessment, 2) advanced statistical methods, and 3) the intersection between placental and cardiovascular health. In the K99 phase of my research, I will leverage data currently being collected in the New York University (NYU) Children’s Health and Environment Study (CHES) that includes both prenatal maternal biomarker and questionnaire data as well as postnatal maternal cardiovascular measures. In the R00 phase, I will incorporate additional preconception data from the NYU Factors Influencing Reproductive Success and Time to Pregnancy (FIRST) Study. Specific Aims include 1) examining relations of maternal prenatal urinary phthalate and bisphenol levels to maternal biomarkers of placental development, and trimester-specific effects of EDCs on placental size at birth, 2) examining relations of prenatal urinary phthalate and bisphenol levels measured in three trimesters of pregnancy to maternal clinical cardiovascular risk factors at 1 and 2 years postpartum in CHES, and 3) assessing relations among maternal preconception phthalate and bisphenol exposure, preconception cardiovascular risk factors, time to pregnancy, and placental growth and development using combined CHES and FIRST data. These training and research activities will increase my expertise as an environmental epidemiologist and prepare me to successfully compete for R01 funding as an independent investigator with a focus on reproductive and women’s health.

项目概要/摘要在美国，越来越多的女性正在经历妊娠并发症，例如先兆子痫、子痫和妊娠高血压，可以让自己和孩子立即特别是，这些妊娠期高血压疾病与长期健康受到威胁有关。女性产后心血管疾病的发病率增加似乎与胎盘有关。调节流向发育中胎儿的营养并影响母体心血管功能的器官。非持久性内分泌干扰化学品 (EDC)，包括塑料中的双酚和邻苯二甲酸盐存在于个人护理产品中，与心血管疾病有关，也可能与在我的硕士、博士和博士后培训过程中，我发现与胎盘功能障碍有关。已经开始开发一系列环境和生殖流行病学方面已发表的研究成果，特别强调确定潜在的生物学机制。使我能够很好地开展我提议的 K99/R00 研究项目：检查母亲之间的关系暴露于非持久性 EDC、胎盘功能障碍的生物标志物和母体指标该独立之路奖将提供怀孕前和怀孕后的心血管疾病。我需要额外的指导和专业知识才能过渡到教师并成功竞争资助我的培训计划包括正式课程、讲习班和研讨会、定向阅读、和学徒培训，以培养以下方面的技能：1) EDC、环境流行病学和暴露评估，2) 先进的统计方法，以及 3) K99 中胎盘和心血管健康之间的交叉点。在我的研究阶段，我将利用纽约大学 (NYU) 目前收集的数据儿童健康与环境研究 (CHES)，包括产前母亲生物标志物和在 R00 阶段，我将纳入问卷数据以及产后母亲心血管测量。来自纽约大学影响生殖成功和怀孕时间的因素的其他先入为主数据（第一）研究的具体目标包括 1）检查母亲产前尿邻苯二甲酸盐与双酚水平对胎盘发育的母体生物标志物的影响，以及 EDC 对妊娠期的特异性影响出生时胎盘大小，2) 检查产前尿液中邻苯二甲酸盐和双酚水平的关系妊娠三个月对产后 1 年和 2 年母亲临床心血管危险因素的影响 CHES，3) 评估母亲孕前邻苯二甲酸盐和双酚暴露之间的关系，孕前心血管危险因素、怀孕时间以及胎盘生长和发育结合 CHES 和 FIRST 数据，这些培训和研究活动将提高我作为一名专家的专业知识。环境流行病学家，帮助我作为独立人士成功竞争 R01 资金专注于生殖和妇女健康的研究者。