ACUTE RADIATION-INDUCED LUNG INJURY IN THE RHESUS MACAQUE AND ITS' TREATMENT BYIPW-5371, A SMALL MOLECULE INHIBITOR OF TGF# RECEPTOR-1 KINASE

恒河猴急性辐射肺损伤及其TGF-β小分子抑制剂YIPW-5371的治疗

• 批准号: 9915646
• 负责人: BARRY HART
• 金额: $ 231.56万
• 依托单位: INNOVATION PATHWAYS, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915646
• 关键词: Acute; Development; Dose; Drug Kinetics; Evaluation; Exposure to; Injury; Ionizing radiation; Macaca mulatta; Modeling; Morbidity - disease rate; Nuclear Accidents; Pharmaceutical Preparations; Phosphotransferases; Radiation; Radiation Accidents; Respiratory physiology; Schedule; Support Contracts; Tissues; Transforming Growth Factor beta; Work; drug synthesis; efficacy study; improved; kinase inhibitor; lung injury; mortality; receptor; scale up; small molecule; small molecule inhibitor

1. This contract supports the development of safe and effective MCMs to mitigate and/or treat tissue injuries arising from exposure to ionizing radiation from a radiological or nuclear incident, thereby leading to a reduction in radiation-associated morbidities and mortalities.

1. 本合同支持开发安全有效的 MCM，以减轻和/或治疗因放射性或核事件电离辐射暴露而造成的组织损伤，从而减少与辐射相关的发病率和死亡率。