Whole genome sequencing for outbreak investigations of foodborne pathogens and antimicrobial resistance studies for FDA Vet-LIRN

用于食源性病原体爆发调查的全基因组测序和 FDA Vet-LIRN 的抗菌药物耐药性研究

基本信息

批准号：
9916178
负责人：
YAN ZHANG
金额：
$ 7.5万
依托单位：
OHIO STATE DEPARTMENT OF AGRICULTURE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-05 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9916178
关键词：
Whole genome sequencing outbreak investigations

项目摘要

FDA CVM Vet-LIRN PROGRAM GRANT PROPOSAL FOR FOA # PAR-18-604 “Vet-LIRN Network Capacity-Building Projects” ABSTRACT This grant proposal from the Ohio Department of Agriculture (ODA) is in response to Funding Opportunity Announcement (FOA) # PAR-18-604 from the Food and Drug Administration’s (FDA) Center for Veterinary Medicine (CVM) Office of Research Veterinary Laboratory Investigation and Response Network (Vet-LIRN). The project is titled “Whole genome sequencing for outbreak investigations of foodborne pathogens and antimicrobial resistance studies for FDA Vet-LIRN”. This proposal from ODA’s Animal Disease Diagnostic Laboratory (ADDL) addresses the following key project areas: 1. Increasing the capacity of laboratories conducting pathogen susceptibility testing by funding the updating or purchasing of additional equipment. 2. Procurement of supplies needed for AMR testing efforts or method improvement. 3. Purchase of liquid handling system for handling of samples for Vet-LIRN foodborne pathogen case investigations. 4. Conduct increased testing in response to a new need identified by the VPO. 5. Participation in multi-laboratory blinded tests to validate newly developed Vet-LIRN Network methods. The ADDL is also poised to address new developments in emerging regulatory sciences as well as urgent or novel areas for potential research. Several additional documents including the internal Proficiency Testing (PT) results (appendix of Research Plan), and certificate of AAVLD accreditation (appendix of Research Plan) are provided along with the

FDA CVM VET LIRN计划赠款提案 FOA＃PAR-18-604 “兽医网络能力建设项目” 抽象的俄亥俄州农业部（ODA）的这项赠款提案是为了回应食品和毒品的资助机会公告（FOA）＃PAR-18-604 管理（FDA）兽医医学中心（CVM）研究办公室兽医实验室研究和反应网络（VET-LIRN）。该项目是标题为“整个基因组测序，用于爆发食物生存的病原体和 FDA兽医lirn的抗菌耐药性研究。 ODA动物疾病诊断实验室（ADDL）的这一提议解决了以下关键项目领域： 1。增加进行病原体敏感性测试的实验室的能力通过资助更新或购买其他设备。 2。采购AMR测试工作所需的供应或方法改进。 3。购买用于处理样品的液体处理系统的兽医。病原体病例调查。 4。响应VPO确定的新需求而增加测试。 5。参与多实验室盲试验以验证新开发的兽医。网络方法。 ADDL也被毒死以解决新兴监管科学的新发展以及潜在研究的紧急或新颖领域。几个其他文件包括内部能力测试（PT）结果（研究计划的附录）和提供了AAVLD认证证书（研究计划的附录）这