Mentoring and Neuroimaging Research on White Matter Pathology in Schizophrenia

精神分裂症白质病理学的指导和神经影像学研究

基本信息

批准号：
9912200
负责人：
Marek Kubicki
金额：
$ 18.89万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-09 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9912200
关键词：
Acute Affect Aging Animals Antipsychotic Agents Appointment Architecture Award Axon Biological Biological Markers Brain Brain Pathology Chronic Schizophrenia Clinic Clinical Collaborations Communication Data Data Set Development Diagnosis Diffusion Diffusion Magnetic Resonance Imaging Foundations Funding General Hospitals Generations Goals Grant Head Hospitals Image Knowledge Laboratories Ligand Binding Macaca mulatta Magnetic Resonance Imaging Massachusetts Measures Mentors Mentorship Methods Microglia Monitor Multimodal Imaging Myelin National Institute of Mental Health Nature Nerve Degeneration Neurobiology Neurons Neurosciences Neurotransmitters Outcome Parents Pathologic Pathology Patients Population Positron-Emission Tomography Postdoctoral Fellow Probability Process Psychiatry Psychotic Disorders Radiology Specialty Research Research Personnel Research Support Research Training Risk Role Scanning Schizophrenia Scientist Senior Scientist Signal Transduction Solid Statistical Models Students Supervision Symptoms Synapses Syndrome Talents Techniques Testing Time TimeLine Training Translating Translational Research United States National Institutes of Health Validation Visit Water Woman Work base career career development cellular pathology data acquisition data harmonization doctoral student early onset extracellular first episode schizophrenia gray matter large datasets mathematical model medical schools mid-career faculty neurobiological mechanism neuroimaging neuroimaging marker neuroinflammation neuroinformatics neuropsychiatric disorder novel parent grant patient oriented patient oriented research programs radiologist skills success summer student theories tool treatment strategy undergraduate student white matter white matter change

项目摘要

Abstract I am a clinical radiologist and neuroscientist by training. I have devoted my research career to understand mechanisms, nature and time-course of white matter pathology in schizophrenia. I am an Associate Professor in Departments of Radiology and Psychiatry at Brigham and Women’s Hospital, Harvard Medical School. I also serve as Associate Director of Psychiatry Neuroimaging Laboratory, Department of Psychiatry at BWH, and as a co-Director of Center for Morphometric Analysis, Department of Psychiatry, and Massachusetts General Hospital, where I have a secondary appointment as research scientist. I have been conducting an NIH sponsored research since 2003, when I received my first R03 award. I am currently PI on an NIMH R01 award, focusing on Development of New Neuroimaging Biomarkers of Risk, Onset and Outcome of Schizophrenia. I am also a PI on NIA funded R01 on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in schizophrenia, aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate thesis students, postdoctoral fellows (including T32 and K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at BWH and at MGH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and schizophrenia.

抽象的我是一名临床放射科医生和神经科学家，我致力于研究。了解白质病理学的机制、性质和时间过程的职业生涯我是放射科和精神病学系的副教授。我还在哈佛医学院布莱根妇女医院担任助理。 BWH 精神病学系精神病学神经影像实验室主任，以及作为精神病学系形态计量分析中心的联合主任，马萨诸塞州总医院，我在那里有第二项研究任命自 2003 年以来，我一直在进行 NIH 资助的研究。获得了我的第一个 R03 奖项，目前我是 NIMH R01 奖项的 PI，专注于开发新的风险、发病和结果神经影像生物标志物我也是 NIA 资助的 R01 项目的 PI，该项目旨在了解精神分裂症的机制。通过一套神经影像工具及其作用，大脑的发育、成熟和衰老在恒河猴中进行的验证有可能实现这两项资助。经过验证的神经影像生物标志物，可用于诊断和监测精神分裂症中髓磷脂缺失和神经炎症导致的神经生物学变化，衰老，以及一系列其他神经精神疾病，其中这些变化除了我的研究之外，我还参与指导哈佛大学、麻省理工学院和波士顿大学。本科生、硕士研究生、博士后（含T32、T32）我也参与了 K23 获奖者、外国研究员和暑期学生。担任 BWH 和 MGH 两个大型实验室负责人的行政工作，以及各种工作最后，我参与了非临床和非 POR。研究（通过我正在进行和悬而未决的动物项目），这使得我的指导和 POR 研究都可以节省时间并帮助我完成任务。专注于对我的职业发展最重要的事情——指导（30%）、进一步培训和新的 POR (20%)，同时将剩余的 50% 用于正在进行的神经影像学研究衰老和精神分裂症中白质变化的生物标志物。