Epidemiology, Immunopathogenesis, and Outcomes of Non-traumatic Spinal Cord Injury in Uganda

乌干达非创伤性脊髓损伤的流行病学、免疫发病机制和结果

• 批准号: 9912215
• 负责人: Abdu Kisekka Musubire
• 金额: $ 10.48万
• 依托单位: INFECTIOUS DISEASES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-22 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912215
• 关键词: Acute Transverse Myelitis; Affect; Africa; Africa South of the Sahara; Age; Algorithms; American; Area; Autoimmune Diseases; Award; Back; Basic Science; Biometry; Biopsy; Blood; CXCL10 gene; Caring; Central Nervous System Infections; Characteristics; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cluster Analysis; Communicable Diseases; Country; Diagnosis; Diagnostic; Disabled Persons; Disease; Enrollment; Epidemiology; Etiology; Evidence based intervention; Extramedullary; Future; Goals; HIV; HIV Infections; Health Care Costs; Histologic; Hospitals; Image; Immune; Immune response; Immunologics; Immunology; Impairment; Incidence; Income; Individual; Inflammation; Inflammatory; Interferon Type II; Interferon-alpha; Interleukin-13; Interleukin-4; Interleukin-6; K-Series Research Career Programs; Learning; Left; Lesion; Magnetic Resonance Imaging; Measures; Mentors; Microbiology; Microscopy; Morbidity - disease rate; Neurologic; Neurological outcome; Neurologist; Neurology; Outcome; Participant; Pathogenesis; Patients; Pattern; Persons; Physical Medicine; Policies; Population; Prevalence; Prognostic Marker; Research; Research Personnel; Resources; Schistosomiasis; Serologic tests; Spinal Cord; Spinal Cord Lesions; Spinal Injuries; Spinal cord injury; Stimulus; Subgroup; Time; Training; Translating; Translational Research; Transverse Myelitis; Uganda; Vascular Diseases; Vertebral column; Virus Diseases; base; bench to bedside; career; chemokine; clinical application; cohort; cost; cost effective; cytokine; demographics; design; disability; epidemiology study; experience; functional outcomes; implementation research; improved; interest; mortality; nervous system disorder; neuroinflammation; next generation sequencing; programs; social; tertiary care; therapy design; tumor

My career goal is to become an independent investigator in the field of neuroinflammatory disorders in Uganda. A variety of neuroinflammatory disorders are common in Uganda, but these disorders are poorly understood. There are only a handful of trained neurologists in Uganda and very few researchers focusing on understanding neurological disorders. Thus, there is a major gap in expertise in this area, and I wish to develop my career to fill this gap through this K43 program by gaining expertise that I can apply to investigating the epidemiology and pathogenesis of neuroinflammatory conditions in Uganda. This K43Award will provide me the support necessary to complete the following goals: 1. Design and execution of Epidemiological studies and clinical trials of neurological conditions in Sub- Saharan Africa. To understand the epidemiology of neurological conditions and design interventions for improving care among neurology patients, I will need additional training and experience related to epidemiology and biostatistics and in design and execution of clinical trials. 2. Neuroinflammation and infections of the central nervous system. To understand the etiology and pathogenesis of neuroinflammation, I will need additional training and experience related to neurological clinical assessments, infections of the central nervous system and neuroinflammation. 3. Translational and implementation research In my future career, I aim to bridge basic science research to clinical application and back. This training and experience will help me to translate findings from bench to bedside and back as I develop new projects as my career develops. I would also be interested in learning how to translate evidence based interventions to practice and policy. I have assembled a team of mentors comprising of the following: primary research mentors-Drs.Boulware (epidemiology and biostatics, infectious diseases) and Dr. Meya (immunology, infectious diseases), and Dr. Bohjanen (microbiology and immunology, infectious diseases) ,Dr. Meyer (neurology, epidemiology of neurological conditions) Prof. Katabira (neurology in HIV infection) and Dr Andrew Kambugu (infectious diseases, clinical research). For this k43 award, I will investigate epidemiology, etiology and pathogenesis of non-traumatic spinal cord injury. I will seek to: (1).To define the etiologies of non-traumatic spinal cord injury (SCI) in Uganda, (2) To determine if the CSF immune signature of idiopathic transverse myelitis can be grouped according to the known infectious etiologies of acute transverse myelitis. (3) To determine the demographic, clinical, and immunologic predictors of poor outcome among individuals with non-traumatic spinal cord injury (SCI). This project will serve as a basis for an R01 application before the end of the K award.

我的职业目标是成为神经炎性疾病领域的独立研究者 乌干达。各种神经炎症性疾病在乌干达很常见，但这些疾病很差 理解。乌干达只有少数受过训练的神经科医生，很少有研究人员专注于 了解神经系统疾病。因此，这一领域的专业知识差距很大，我希望 通过获得我可以调查的专业知识，通过这项K43计划来填补这一空白，以填补这一空白 乌干达神经炎症状况的流行病学和发病机理。 这个K43award将为我提供完成以下目标所需的支持： 1。在亚 - 撒哈拉非洲。了解神经系统状况和设计干预措施的流行病学 改善神经病学患者的护理，我将需要与 流行病学和生物统计学以及临床试验的设计和执行。 2。中枢神经系统的神经炎症和感染。了解病因和 神经炎症的发病机理，我需要与神经系统相关的其他培训和经验 临床评估，中枢神经系统的感染和神经炎症。 3。翻译和实施研究 在我未来的职业生涯中，我旨在将基础科学研究桥接到临床应用和返回。这个培训 经验将帮助我在开发新项目时将发现从长凳转换为床边然后返回 随着我的职业发展。我也有兴趣学习如何翻译基于证据的干预措施 练习和政策。 我组建了一个由以下组成的导师团队：主要研究导师-DRS.Boulware （流行病学和生物统计学，传染病）和Meya博士（免疫学，传染病）和博士 Bohjanen（微生物学和免疫学，传染病），博士。 Meyer（神经学，流行病学 神经系统疾病）Katabira教授（HIV感染中的神经病学）和Andrew Kambugu博士（感染性 疾病，临床研究）。 对于这个K43奖，我将研究非创伤性脊髓的流行病学，病因和发病机理 受伤。我将寻求：（1）。定义乌干达非创伤性脊髓损伤（SCI）的病因，（2） 确定是否可以根据特发性术的CSF免疫特征来根据 已知的急性横向脊髓炎的感染病因。 （3）确定人口，临床和 非创伤性脊髓损伤（SCI）个体中预后不良的免疫学预测因子。 该项目将在K奖授予结束之前作为R01申请的基础。