Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety

抑郁和焦虑中消极情感维度的跨诊断神经机制

• 批准号: 9912199
• 负责人: Jay C Fournier
• 金额: $ 54.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912199
• 关键词: Acute; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Brain; Clinical; Conflict (Psychology); Conscious; Data; Depressive disorder; Dimensions; Distress; Dorsal; Emotional; Emotions; Ensure; Functional disorder; Future; Goals; Grain; Hostility; Impairment; Individual; Lead; Measures; Mental Depression; Mental disorders; Modeling; Mood Disorders; National Institute of Mental Health; Nature; Neurobiology; Neuronal Dysfunction; Occupational; Participant; Pattern; Phenotype; Prefrontal Cortex; Process; Productivity; Protocols documentation; Psychiatric Diagnosis; Psychopathology; Public Health; Regulation; Research Domain Criteria; Rest; Severities; Shame; Symptoms; System; Testing; Visit; Work; anxiety symptoms; base; brain abnormalities; cingulate cortex; cognitive control; depressive symptoms; diaries; emotion regulation; emotional experience; experience; follow up assessment; follow-up; functional outcomes; humiliation; improved; individualized medicine; interest; negative affect; network dysfunction; neural circuit; neural model; neural patterning; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; novel; personalized medicine; prospective; psychiatric symptom; recruit; relating to nervous system; response; secondary analysis; young adult

ABSTRACT There is growing recognition that strict distinctions between clinical psychiatric disorders such as anxiety and depression, on the one hand, and more stable dispositions to experience negative emotions (negative affectivity), on the other, fail to capture the true nature of psychopathology. We argue that by examining specific dimensional phenotypes that cut across depression and anxiety disorders, we will be better able to identify the neurobiological processes that are specifically associated with an individual's distress and dysfunction – a critical step for developing more effective, targeted treatments. Negative affectivity is a broad dimension that underlies depression and anxiety and is associated with enormous public health consequences. One of the specific facets of negative affectivity, excessive self-consciousness, may represent a dimensional phenotype that is closely aligned with a specific pattern of dysfunction in neural mechanisms that can lead to difficulties regulating emotional responses. Excessive self-consciousness refers to the tendency to feel shame, humiliation, and inadequacy. Our preliminary data suggest that it is strongly associated with altered functioning in self-related processing neural regions and in regions responsible for emotion regulation, over and above acute psychiatric symptoms. Furthermore, our findings suggest that excessive self-consciousness is strongly associated with specific types of real-world interpersonal problems. The primary goals of this project are to test a novel model of neural dysfunction during emotion regulation associated with excessive self-consciousness and to examine the real-world consequences of that dysfunction. To achieve these goals, 125 young adults (18-25 years old) with at least mild symptoms of depression or anxiety will be recruited. In addition, 75 demographically matched, psychiatrically healthy individuals will be recruited to ensure that we capture the full range for all of the dimensions of interest. Participants will complete clinical and neuroimaging assessments, as well as 6- and 12-month follow-up assessments that will include weeklong daily diary protocols of real-world functioning. The project will examine 1) whether excessive self-consciousness is associated with abnormal functioning in self-related processing regions; 2) whether excessive self-consciousness is associated with abnormalities in the functioning of the emotion regulation circuit; and 3) whether abnormalities in these neural systems prospectively predict psychiatric symptoms and poorer interpersonal and work functioning 6 and 12 months later. The aims of the project match well with the strategic goals of the National Institute of Mental Health, and the results of this study have the potential to describe specific neurobiological mechanisms associated with excessive self-consciousness – a dimensional phenotype that cuts across anxiety and depressive disorders. Future work will aim to develop personalized treatments to target the neural mechanisms identified in this study in order to reduce distress and improve functional outcomes.

抽象的 越来越认识到临床精神疾病（例如动画和）的严格区别 一方面，抑郁症和更稳定的性格来体验负面情绪（负面情绪 另一方面，情感）无法捕捉精神病理学的真实本质。我们认为通过检查 特定的维度表型削减了抑郁症和焦虑症，我们将能够更好地 确定与个人困扰特别相关的神经生物学过程 功能障碍 - 开发更有效，有针对性治疗的关键步骤。负面情感是广泛的 抑郁症和焦虑的维度，与巨大的公共卫生后果有关。 负面情感的特定方面之一，过度的自我意识可能代表一个维度 表型与神经机制中的特定功能障碍模式紧密对齐，这可能导致 难以控制情绪反应。过度的自我意识是指感到羞耻的趋势， 屈辱和不足。我们的初步数据表明，它与功能变化密切相关 在自我相关的处理神经元区域以及负责情绪调节的地区 急性精神病症状。此外，我们的发现表明超级自我意识是强烈的 与特定类型的实际人际交往问题相关。该项目的主要目标是测试 情绪调节期间神经功能障碍的新型模型与过度自我意识相关 并检查该功能障碍的现实后果。为了实现这些目标，有125名年轻人 （18-25岁）至少会出现轻度的抑郁症或焦虑症状。另外，75 人口统计学匹配，精神健康的人将被招募，以确保我们捕捉到完整的 所有感兴趣的维度的范围。参与者将完成临床和神经影像学评估， 以及6个月和12个月的随访评估，其中包括为期一周的每日日记协议 功能。该项目将检查1）过度自我意识是否与异常有关 在自我相关的处理区域中运作； 2）过度的自我意识是否与 情绪调节电路功能的异常； 3）这些中性异常是否异常 系统可以预测精神病症状和较差的人际关系和工作功能6和12 几个月后。该项目的目的与国家心理研究所的战略目标非常吻合 健康，这项研究的结果有可能描述特定的神经生物学机制 与多余的自我意识相关 - 一种维度表型，跨越焦虑和 抑郁症。未来的工作将旨在开发个性化治疗方法，以针对神经机制 在本研究中确定，以减少困扰并改善功能结果。