Sports Related Subconcussive Impacts in Children: MRI & Biomechanical Correlates

儿童运动相关的亚脑震荡影响：MRI

• 批准号: 8748697
• 负责人: Joseph A Maldjian
• 金额: $ 7.46万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8748697
• 关键词: 12 year old; Area; Attention; Award; Behavior assessment; Biomechanics; Biomedical Engineering; Biometry; Brain; Brain Concussion; Child; Childhood; Childhood Injury; Clinical; Cognitive; Collaborations; Collection; Control Groups; Craniocerebral Trauma; Data; Data Analyses; Data Collection; Data Set; Databases; Diffusion; Diffusion Magnetic Resonance Imaging; Elements; Enrollment; Equipment; Funding; Grant; Head; Health Sciences; Human Resources; Image; Individual; Injury; Investments; Letters; Magnetic Resonance Imaging; Manufactured football; Measures; Mediating; Metric; Monitor; Neurocognitive; Neuropsychological Tests; Parents; Participant; Recording of previous events; Research; Research Personnel; Risk; Seasons; Sports; System; Technology; Telemetry; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Universities; Weight; Work; Youth; age group; base; clinical epidemiology; college; data acquisition; experience; forest; graduate student; high school; instrument; member; neuroimaging; neuropsychological; prevent; public health relevance; research clinical testing

DESCRIPTION (provided by applicant): Title: Sports-related sub concussive impacts in children: MRI & biomechanical correlates Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional and collegiate levels, there is little data at the high school level and scarceif any data available for participants in the youth leagues (8-12 years old). This study will relate information about biomechanical forces experienced during a hit in youth football to neurocognitive and imaging data to determine the effects of subconcussive impacts. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI). In this R03 we will investigate the biomechanical and cognitive correlates of diffusion MRI scalar measures of mTBI in children. This project leverages the investments by Wake Forest University Health Sciences which has identified, instrumented and enrolled youth football players, and funded the data collection as part of our ongoing work in this area of critical public importance. We already have acquired a very rich data set of ~30 youth players (8- 12 years old) followed over the course of an entire season (2012 football season). All players were instrumented with the Head Impact Telemetry System (HITS) for collection of real-time impact data during all practices and games. Baseline, post-season and post-concussion multimodal magnetic resonance imaging (MRI), including structural T1-weighted, and diffusion tensor and kurtosis imaging (DTI/DKI) were performed in all subjects. Neurocognitive assessments using the pediatric Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) were obtained at baseline, post-injury, and post-season. Data acquisition is now continuing into the 2013 season with 30 new players already being monitored with HITs, and having all received baseline imaging and neuropsychologic testing including IMPACT testing and additional NIH toolbox measures. We have also recently been awarded internal institutional funding for acquiring a non-contact sport control data set (25 participants), including imaging and cognitive testing at baseline and post-season. This R03 will help fund a graduate student in Biomedical Engineering to assist in the MRI diffusion analyses of the acquired youth football and control data. The utilization of state-of-the-art HITs technology and the acquisition of HITs data at all practices and games provides an extremely thorough characterization of the biomechanical forces experienced by the brains of the young athletes. This unique data set represents the largest of its type in the world, combining imaging, cognitive testing and biomechanical measures in the youth age group. The long term benefit of the research will be to allow equipment designers, researchers, and clinicians to better prevent, mitigate, identify and treat injuries to help make football a safer activity for millions of children.

描述（由申请人提供）： 标题：儿童运动相关的次脑震荡影响：MRI 和生物力学相关性 足球头部损伤涉及巨大的力量，可能导致轻度至重度创伤性脑损伤。虽然这已受到越来越多的关注 在职业和大学层面，高中层面的数据很少，而且青年联赛参与者（8-12岁）的数据也很少。这项研究将把青少年足球比赛中所经历的生物力学信息与神经认知和成像数据联系起来，以确定亚脑震荡影响的影响。本研究的所有内容均以增进对儿科轻度创伤性脑损伤 (mTBI) 的了解为目标。在本 R03 中，我们将研究儿童 mTBI 的扩散 MRI 标量测量的生物力学和认知相关性。该项目利用了维克森林大学健康科学部的投资，该大学已识别、装备和招募青少年足球运动员，并资助数据收集，作为我们正在进行的工作的一部分 对公众具有重要意义的领域。我们已经获得了非常丰富的数据集，其中包含大约 30 名青少年球员（8-12 岁）在整个赛季（2012 年足球赛季）的跟踪记录。所有球员都配备了头部撞击遥测系统（HITS），用于在所有练习和比赛期间收集实时撞击数据。对所有受试者进行基线、赛季后和脑震荡后多模态磁共振成像 (MRI)，包括结构 T1 加权、弥散张量和峰度成像 (DTI/DKI)。使用儿科脑震荡后立即评估和认知测试（ImPACT）在基线、受伤后和赛季后进行神经认知评估。数据采集​​现已持续到 2013 年赛季，30 名新球员已接受 HIT 监测，并且全部接受了基线成像和神经心理学测试，包括 IMPACT 测试和其他 NIH 工具箱测量。我们最近还获得了内部机构资助，用于获取非接触式运动控制数据集（25 名参与者），包括基线和季后的成像和认知测试。该 R03 将帮助资助一名生物医学工程研究生，以协助对获得的青少年足球和控制数据进行 MRI 扩散分析。利用最先进的 HIT 技术并在所有练习和比赛中采集 HIT 数据，可以非常全面地描述年轻运动员大脑所经历的生物力学力。这个独特的数据集代表了世界上同类数据中最大的数据集，结合了青年群体的成像、认知测试和生物力学测量。这项研究的长期好处将是让设备设计师、研究人员和临床医生能够更好地预防、减轻、识别和治疗伤害，帮助让足球成为数百万儿童更安全的活动。