Administration and Regulation of Activities associated with The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical Discovery

范德比尔特泌尿感染信息库（个性化临床发现资源）相关活动的管理和监管

• 批准号: 9913351
• 负责人: Maria Hadjifrangiskou
• 金额: $ 10.02万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9913351
• 关键词: Academia; Academic Medical Centers; Adult; Advisory Committees; Area; Award; Benign; Big Data; Biological; Biology; Child; Clinical; Clinical Pathology; Collaborations; Communicable Diseases; Communication; Communities; Country; Data; Data Analyses; Development; Education; Educational workshop; Ensure; Environment; Epidemiologist; Event; Faculty; Fertilization; Fostering; Foundations; Fruit; Genitourinary System Infection; Genitourinary system; Goals; Health; Heterogeneity; Hospitals; Human Resources; Immersion Investigative Technique; Individual; Infection; Informatics; Infrastructure; Institutes; Internships; Laboratories; Lead; Leadership; Light; Logistics; Medical; Medicine; Mission; Occupational activity of managing finances; Online Systems; Operating System; Organism; Parents; Pathogenesis; Pathology; Patients; Persons; Pilot Projects; Postdoctoral Fellow; Process; Productivity; Regulation; Research; Research Personnel; Resources; Rotation; Scholarship; Science; Series; Services; Societies; Specialist; Specimen; Structure; Supervision; Time; Underrepresented Groups; United States; United States National Institutes of Health; Urinary tract infection; Urology; Vision; Work; biobank; career development; clinically relevant; collaborative environment; combat; community building; data warehouse; design; experience; flexibility; host-microbe interactions; innovation; lectures; microbial; microbiome; multidisciplinary; novel diagnostics; novel therapeutics; operation; organizational structure; outreach; pathogen; personalized medicine; precision medicine; programs; recruit; repository; success; synergism; tool; undergraduate student; urologic; web site

SUMMARY - ADMINISTRATIVE CORE We propose the Vanderbilt Urologic Infection Repository (VUIR) as a first-in-kind resource for host-pathogen discovery, one that systematically connects [1] medical data from a vast number of patients who suffer from urinary tract infections (UTIs) to [2] a biobank of the actual causative organisms. As an informatic and biologic network, the VUIR will facilitate novel diagnostic and therapeutic strategies to combat UTIs, while providing a tool to elucidate their underlying pathogenesis. At the same time—given the extensive scope of the VUIR and its potential for multidisciplinary innovation—the need arises for a strong administrative foundation to coordinate the program's daily activities and bring to fruition its scientific vision. To these ends, a critical strength of the VUIR will be its associated Administrative Core (AdCore), a defined personnel structure for organizational success. The faculty leadership team of the AdCore holds broad expertise in clinical urology (Dr. Douglass Clayton), microbial pathogenesis (Dr. Maria Hadjifrangiskou), and clinical pathology/laboratory medicine (Dr. Jonathan Schmitz), further supported by both a Local Executive Committee and External Advisory Committee. These groups will likewise include strategic representation from informaticians, infectious disease specialists, hospital epidemiologists, and microbiome experts, providing ongoing thematic direction to the VUIR from the diverse fields to which the program will contribute. The AdCore will also incorporate dedicated logistical support from professionals with extensive background in academic and financial administration, as well as web-site design and event management. In total, this group will ensure that our logistical operations are both proactive and responsive, coordinating interactions and disseminating specimens/data within and beyond Vanderbilt. The AdCore will create synergy between the VUIR and complementary institutional structures for precision medicine and translational discovery, as well as champion pilot projects that build upon VUIR resources. Our ultimate goal, however, is to create a network of affiliated collaborators across the United States, clinicians and investigators who could both benefit from and contribute to the combined wealth of data and specimens. Finally, in addition to supporting scientific innovations, the AdCore will ensure we develop a concomitant footprint in education and service. Through a combination of workshops, seminars, and immersive experiences, we will connect nationwide experts in urogenital infection-biology to diverse trainees, from undergraduate students to postdoctoral/clinical fellows. In addition to content-area education, these interactions will foster networking and career-development experiences, including opportunities for individuals from underrepresented groups. And reaching beyond academia, the AdCore will promote outreach to the larger community, building on existing Vanderbilt programs to educate the public on our scientific mission. In this way, this administrative foundation of the VUIR will maximize the program's ability to generate discoveries, while disseminating information to broad and varied audiences.

摘要 - 行政核心 我们建议将范德比尔特泌尿感染存储库 (VUIR) 作为宿主病原体的首个同类资源 一项发现，系统地将来自大量患有以下疾病的患者的医疗数据连接起来 [1] 尿路感染 (UTI) [2] 实际致病微生物的生物库作为信息学和生物学。 VUIR 将促进新的诊断和治疗策略来对抗尿路感染，同时提供 同时考虑到 VUIR 和的广泛范围。 其多学科创新的潜力——需要强大的行政基础来协调 该计划的日常活动并实现其科学愿景是实现这些目标的关键力量。 VUIR 将是其相关的管理核心 (AdCore)，这是组织的明确的人员结构 AdCore 的教师领导团队在临床泌尿学领域拥有广泛的专业知识（道格拉斯博士） Clayton）、微生物发病机制（Maria Hadjifrangiskou 博士）和临床病理学/实验室医学（Dr. Jonathan Schmitz），并得到当地执行委员会和外部咨询委员会的进一步支持。 这些小组同样将包括来自信息学家、传染病专家、 医院流行病学家和微生物组专家为 VUIR 提供持续的主题指导 AdCore 还将纳入专门的后勤支持。 来自在学术和财务管理以及网站方面具有丰富背景的专业人士 总的来说，该团队将确保我们的后勤运营是积极主动的。 响应、协调互动并在范德比尔特内外传播样本/数据。 AdCore 将在 VUIR 和精准医疗的互补机构结构之间建立协同作用 和转化发现，以及基于 VUIR 资源的冠军试点项目，我们的最终目标， 然而，是要建立一个由遍布美国的附属合作者、人群和调查人员组成的网络 谁可以从数据和样本的综合财富中受益并做出贡献。 支持科学创新，AdCore 将确保我们在教育和 通过研讨会、研讨会和沉浸式体验的结合，我们将连接全国。 泌尿生殖感染生物学专家到不同的受训者，从本科生到博士后/临床 除了内容领域的教育之外，这些互动还将促进网络和职业发展。 经验，包括为来自代表性不足的群体的个人提供机会，并超越他们。 学术界，AdCore 将在现有范德比尔特项目的基础上，促进向更大社区的推广 通过这种方式，VUIR 的行政基金会将向公众宣传我们的科学使命。 最大限度地提高该计划产生发现的能力，同时将信息传播到广泛和多样化的领域 观众。