Mouse Phenome Database: NIA Interventions Testing Program Data Coordinating Center

小鼠表型组数据库：NIA 干预测试计划数据协调中心

• 批准号: 9911521
• 负责人: MOLLY A BOGUE
• 金额: $ 13.6万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911521
• 关键词: Aging; Amino Acids; Animal Model; Architecture; Biological; Biology of Aging; Chelating Agents; Collaborations; Collection; Communities; Complement; Computational Science; Data; Data Analyses; Data Coordinating Center; Data Set; Databases; Discipline; Disease; Documentation; Ensure; Environment; Evaluation; FAIR principles; Food; Foundations; Functional disorder; Genetic; Genetic study; Genomics; Goals; Growth; Health; Hormones; Imagery; Informatics; Intervention; Investigational Drugs; Knowledge; Laboratories; Longevity; Maintenance; Methods; Michigan; Modernization; Mollies; Mus; Nutraceutical; Outcome; Oxidation-Reduction; Pathology; Peptides; Pharmacologic Substance; Phenotype; Plant Extracts; Population; Population Heterogeneity; Predictive Value; Protocols documentation; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Scientific Advances and Accomplishments; Secure; Shock; Site; Software Engineering; Specimen; Standardization; System; Testing; Texas; The Jackson Laboratory; Translations; Universities; Work; age related; biobank; bioinformatics resource; collaborative environment; data access; data management; data visualization; data warehouse; design; dietary supplements; dissemination research; experience; flexibility; healthspan; improved; insight; normal aging; phenome; programs; public health relevance; repository; research data dissemination; response; tool; web page; web portal; web site

PROJECT SUMMARY/ABSTRACT The NIA Interventions Testing Program (ITP) is a multi-institutional study investigating interventions with the potential to extend lifespan and delay disease or dysfunction in mice. Interventions are tested in parallel at three sites (The Jackson Laboratory, University of Michigan, and University of Texas) using identical standardized protocols. Such treatments include pharmaceuticals, nutraceuticals, foods, dietary supplements, plant extracts, hormones, peptides, amino acids, chelators, redox agents, and other compounds or mixtures of compounds. We propose to advance the Mouse Phenome Database (MPD) in response to emerging needs of the aging research community, specifically the ITP, to become a Data Coordinating Center (DCC) that curates ITP data, makes it available through a public database, and provides tools that enable users to visualize, analyze, and download the primary and summary data from these studies. Our objectives are to provide a central repository for data, documentation, and protocols, offering a unique and important venue for ITP investigators needing to make their data public; to continually refine and develop tools and features to best locate, present, and analyze those datasets; and to maintain, enhance, and promote this resource to further enable quantitative, standardized and predictive phenotype studies and, in turn facilitate new scientific advances in the field of aging. During the previous five years, we have designed a publicly accessible website and data repository for the ITP. We have also curated and posted data from numerous ITP studies. ITP plans for the next five years include additional lifespan trials, detailed analyses of agents found to increase lifespan, and continued growth in data on health outcomes. To help support these goals, our specific aims are to: 1) refine and maintain the current MPD-ITP website, 2) populate MPD with rigorously curated ITP data, 3) develop and extend the suite of MPD tools to support flexible analysis and visualization of ITP data, and 4) develop and maintain a publicly accessible database of ITP biospecimens available for external investigators to conduct their own studies in a collaborative manner. Completion of the proposed work for the ITP DCC will result in a powerful FAIR-compliant system (Findable, Accessible, Interoperable, and Reusable) for public access to and analysis of ITP data. This will help maximize the value of these data and provide the traceability and reproducibility required for extension and translation of the outcomes of ITP testing.

项目摘要/摘要 NIA干预测试计划（ITP）是一项多机构研究，研究了与 延长寿命并延迟小鼠疾病或功能障碍的潜力。干预措施并行测试 三个地点（密歇根大学杰克逊实验室和德克萨斯大学）使用相同 标准化协议。这些治疗方法包括药品，营养素，食品，饮食补充剂， 植物提取物，激素，肽，氨基酸，螯合剂，氧化还原剂以及其他化合物或混合物 化合物。我们建议以响应新兴需求来推进鼠标现象数据库（MPD） 老化的研究社区，特别是ITP，成为一个数据协调中心（DCC），该中心策划 ITP数据，通过公共数据库提供，并提供使用户可视化， 分析这些研究中的主要和摘要数据。我们的目标是提供 数据，文档和协议的中央存储库，为ITP提供独特而重要的场地 需要公开数据的调查人员；不断完善和开发工具和功能以最佳 找到，呈现和分析这些数据集；并维护，增强和促进此资源以进一步 启用定量，标准化和预测的表型研究，进而促进新的科学进步 在衰老领域。在过去的五年中，我们设计了一个可公开访问的网站和数据 ITP的存储库。我们还策划并发布了来自众多ITP研究的数据。 ITP计划 接下来的五年包括额外的寿命试验，发现寿命增加的代理的详细分析以及 健康结果数据的持续增长。为了帮助支持这些目标，我们的具体目标是：1） 并维护当前的MPD-ITP网站，2）用严格策划的ITP数据填充MPD，3）开发和 扩展MPD工具的套件以支持ITP数据的灵活分析和可视化，4）开发和 维护可公开访问的ITP生物测量数据库，可供外部调查人员进行 他们自己的研究以协作方式。完成ITP DCC的拟议工作将导致 强大的公平兼容系统（可访问，可访问，可互操作和可重复使用），可公开访问和 ITP数据的分析。这将有助于最大化这些数据的价值，并提供可追溯性和 扩展和翻译ITP测试结果所需的可重复性。