PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Gra

PHS 2018-02 NIH、CDC 和 FDA 小型企业创新研究综合征集

• 批准号: 9907813
• 负责人: DANA K SMITH
• 金额: $ 22.5万
• 依托单位: OREGON RES BEHAVIORAL INTERVENTION STRAT
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2020-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907813
• 关键词: PHS; 2018; 02; Omnibus; Solicitation

Abstract Despite overall declines in the rate of tobacco use in the United States over the past 30 years, nearly 38 million Americans still smoke, posing extremely high risk for long-term health problems and death. There has been extensive research evaluating a wide range of smoking cessation approaches over the past 40 years. Recent reviews note that there has been significant progress in the application of both clinical and public health interventions to help smokers quit; however, they have also concluded that the overall success rate of smokers quitting has not significantly improved. Individual, group and public health interventions – both with and without adjunctive aids such as nicotine replacement therapy – have generally used some combination of cognitive-behavioral interventions, but there remains a need for novel, theory-driven approaches to enhance quit rates and innovative interventions that increase reach and engagement, such as those offered via computer or mobile app. We propose to adapt and test the feasibility of a previously piloted cognitive dissonance intervention (CDI) for smoking cessation that will be delivered via a mobile app. Cognitive dissonance interventions have been shown to be successful in treating health-related problems, as well as substance use, and preliminary findings support its use in smoking cessation. The program will be evaluated with 60 adult daily smokers and will be the only cognitive dissonance mobile app for smoking cessation. Our research and development team has extensive experience developing and testing mobile apps and developing and testing cognitive dissonance and smoking cessation interventions. In the first phase, we will use an iterative development plan to design and develop functionality of the first 3 modules of the CDI prototype app. The research team will partner with Twenty Ideas who have extensive experience in the development of mobile apps for smartphones, many of which have been commercialized. We will assess navigation and usability with adult daily smokers. Additional pilot testing will be used to create a prototype version for evaluation. The evaluation study will involve having 60 adults use the app and complete baseline, 1- and 3-month follow-up. Usability data, system log data on program use, and participant satisfaction data will also be analyzed. Input from participants will be gathered to incorporate additional features to be developed during Phase II. Significant changes in quit attempts, number of days without smoking (smokefree days) and changes in smoking attitudes and behavior will be used to determine the efficacy of the Phase I program and evidence for proceeding to Phase II development and evaluation.

抽象的 尽管在过去30年中，美国的烟草使用率总体下降，但几乎 仍有3800万美国人吸烟，对长期健康问题和死亡构成极高的风险。那里 在过去的40个中，已经进行了广泛的研究，评估了广泛的戒烟方法 年。最新评论指出，临床和公众的应用取得了重大进展 健康干预措施以帮助吸烟者戒烟；但是，他们还得出结论，总体成功率 吸烟者的安静尚未显着改善。个人，团体和公共卫生干预措施 - 都 并且没有辅助辅助药，例如尼古丁替代疗法 - 通常使用了某种组合 认知行为的干预措施，但仍需要新颖的，理论驱动的方法来增强 退出率和创新干预措施，以增加覆盖范围和参与度，例如通过 计算机或移动应用。我们建议适应和测试先前试验的认知的可行性 通过移动应用程序提供的戒烟的不和谐干预（CDI）。认知的 不谐调干预措施已被证明在治疗与健康有关的问题方面取得了成功， 药物使用和初步发现支持其在戒烟中的使用。该程序将进行评估 每天有60名成人吸烟者，将是唯一的认知失调移动应用程序，用于戒烟。我们的 研发团队拥有广泛的开发和测试移动应用程序并开发的经验 并测试认知失调和戒烟干预措施。在第一阶段，我们将使用 迭代开发计划，设计和开发功能CDI原型应用程序的前3个模块。 研究团队将与二十个想法合作，他们在移动的发展方面有丰富的经验 智能手机的应用程序，其中许多已商业化。我们将评估导航和可用性 成人日常吸烟者。其他试点测试将用于创建原型版本以进行评估。这 评估研究将涉及让60名成年人使用该应用程序和完整的基线，即1个月和3个月的随访。 还将分析有关程序使用的可用性数据，系统日志数据以及参与满意度数据。输入 将收集来自参与者的内容，以合并在第二阶段期间要开发的其他功能。重要的 戒烟尝试的变化，没有吸烟的天数（无烟日）和吸烟的变化 和行为将用于确定I期计划的效率以及继续进行的证据 第二阶段的开发和评估。