Analyzer-based Phase Contrast Imaging System Development and Evaluation

基于分析仪的相差成像系统开发和评估

• 批准号: 9906224
• 负责人: Jovan G Brankov
• 金额: $ 49.89万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906224
• 关键词: Address; Algorithms; Animal Cancer Model; Anodes; Breast; Cadaver; Cancer Detection; Chicago; Clinic; Clinical; Collection; Complex; Computer Simulation; Computer software; Contrast Media; Data; Development; Devices; Diagnostic radiologic examination; Digital Breast Tomosynthesis; Digital Mammography; Disadvantaged; Discrimination; Dose; Elements; Evaluation; Fatigue; Goals; Healthcare Systems; Human; Hybrids; Image; Legal patent; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Mammographic screening; Mammography; Measurement; Methods; Modality; Modeling; Motivation; Operative Surgical Procedures; Optics; Output; Performance; Phase; Physics; Process; Protocols documentation; Publishing; Radiation Dose Unit; Rattus; Reader; Reading; Reporting; Resolution; Roentgen Rays; Scanning; Series; Source; Specificity; Specimen; Spiculate; Synchrotrons; System; Systems Development; Task Performances; Testing; Time; Tissue imaging; Visualization; Woman; Women' s Health; Work; X-Ray Computed Tomography; base; breast imaging; calcification; clinical development; contrast imaging; density; design; design and construction; digital; follow-up; image processing; image reconstruction; imaging modality; imaging system; improved; innovation; malignant breast neoplasm; models and simulation; mortality; novel; photon-counting detector; prototype; quantitative imaging; radiologist; reconstruction; screening; simulation; soft tissue; tissue phantom; tomosynthesis; tool; tumor

The proposed project concerns a new design for a novel, low-dose x-ray device for analyzer-based phase contrast imaging (ABI), a modality that uses x-ray refraction to produce dramatic improvements in imaging of the breast and other soft tissues. ABI has been well documented to produce extraordinary images at synchrotron facilities, but compact ABI prototypes have required imaging times that are far longer than what is practical for clinical use. We have developed a breakthrough approach, including a number of innovative design concepts that, when combined, are expected to deliver whole-breast imaging at 100 µm resolution in 8.3 seconds. The goal of the proposed project will be to methodically design, optimize, and construct such an ABI system and evaluate its output in an expert reader study. ABI imaging offers many important potential benefits: 1) ABI has very high inherent soft-tissue image contrast due to the physics of x-ray refraction and strong scatter rejection, promising to provide clear visualization of calcifications and spiculations; 2) ABI can act as a planar-imaging method like mammography, but can also be used in tomosynthesis or computed tomography (CT) modes; 3) ABI has no need for injected contrast agent; 4) ABI may reduce radiation dose, because it can operate at higher x-ray energies (quasi- monochromatic at ~60keV); 5) the image detail seen in ABI may ultimately eliminate the need for tomosynthesis or CT, resulting in fewer images to be read in the clinic; 6) ABI may permit calcification types to be discriminated, thereby improving specificity; and 7) ABI permits quantitative imaging of tissue density. Based on a preliminary prototype device, we have established strong evidence of feasibility of clinically practical ABI performance. ABI system development is a complex hardware-software co-design process. The main elements in this process will define the project's specific aims as follows: 1. Design and construct a compact ABI imaging system to demonstrate practical imaging time. 2. Develop simulation and phantom tools. 3. Optimize image processing and iterative reconstruction methods. 4. Evaluate imaging system using ex vivo whole breast specimens and hybrid tissue phantoms.

拟议的项目涉及针对新颖的低剂量X射线设备的新设计 基于分析仪的相位造影剂成像（ABI），一种使用X射线折射的方式 在乳房和其他软组织的成像中产生巨大的改进。阿比有 我们有充分的文献记载，可以在同步器设施中制作出非凡的图像，但是 紧凑的ABI原型需要成像时间，其时间远远超过了 用于临床用途的实用性。我们已经开发了一种突破性的方法，包括 预计将交付的创新设计概念数量 在8.3秒内以100 µm分辨率进行全胸成像。提议的目标 项目将有条不紊地设计，优化和构建这样的ABI系统和 在一项专家读者研究中评估其输出。 ABI成像提供了许多重要的 潜在的好处：1）ABI由于该公司具有很高的继承软组织图像对比度 X射线折射的物理学和强烈的分散拒绝，保证提供清晰的 可视化钙化和症状； 2）ABI可以充当平面成像 诸如乳房X线摄影之类的方法，但也可以用于合成或计算 断层扫描（CT）模式； 3）ABI不需要注入造影剂； 4）Abi May 减少辐射剂量，因为它可以在较高的X射线能量（准 单色〜60kev）; 5）ABI中看到的图像细节最终可能消除 需要进行白合或CT，导致在诊所阅读的图像较少； 6）ABI 可以允许歧视计算类型，从而提高特异性；和7） ABI允许对组织密度进行定量成像。基于初步原型 设备，我们已经建立了有力的临床实用ABI可行性的有力证据 表现。 ABI系统开发是一个复杂的硬件软件共同设计 过程。此过程中的主要元素将定义项目的特定目的 如下：1。设计和构建一个紧凑的ABI成像系统以证明实用性 成像时间。 2。开发模拟和幻影工具。 3。优化图像处理 和迭代重建方法。 4。使用离体整体评估成像系统 野兽标本和杂交组织幻象。