Predictors of myelodysplastic syndrome in Minnesota

明尼苏达州骨髓增生异常综合征的预测因子

基本信息

批准号：
8617812
负责人：
Jenny N. Poynter
金额：
$ 50.57万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8617812
关键词：
Accounting Acute Myelocytic Leukemia Address Adult Adult Acute Myeloblastic Leukemia Affect Age American American Indians Anti-Inflammatory Agents Anti-inflammatory Asians Benzene British Cancer Center Case-Control Studies Categories Cells Cessation of life Chemical Exposure Chemicals Chronic Myelomonocytic Leukemia Classification Clinic Collection Controlled Study DNA Data Development Diagnosis Diet Drug usage Dysmyelopoietic Syndromes Enrollment Epidemiologic Studies Epidemiology Etiology Exposure to Family history of Frequencies Funding Future Genetic Predisposition to Disease Genotype Goals Health Hematologic Neoplasms Hematopoietic Neoplasms Hematopoietic System Hispanics Hospitals Incidence Individual International Knowledge Lead Letters Literature Malignant Glioma Malignant Neoplasms Medical Records Minnesota Myeloid Leukemia Newly Diagnosed Not Hispanic or Latino Obesity Occupational Exposure Outcome Overweight Pacific Island Americans Pathology Patients Personal Communication Pesticides Population Control Positioning Attribute Prevention Prevention strategy Process Prognostic Factor Public Health Questionnaires Radiation Recording of previous events Refractory anemias Reporting Research Infrastructure Residual state Rheumatoid Arthritis Risk Risk Factors Role SEER Program Saliva Solvents Suggestion Surveys Susceptibility Gene System Time United States United States National Institutes of Health World Health Organization adult leukemia base case control chemotherapy cigarette smoking comparative genomic hybridization cost effective follow-up genetic analysis high risk improved indexing insight leukemia lifestyle factors neoplasm registry novel pesticide exposure population based prognostic public health relevance

项目摘要

DESCRIPTION (provided by applicant): Myelodysplastic syndrome (MDS) is a heterogeneous disruption of the hematopoietic system that can lead to the development of acute myeloid leukemia (AML) in about 1/3 of cases. MDS became reportable to the Surveillance, Epidemiology and End Results program in 2001. It is estimated that about 10,000 MDS cases are newly diagnosed each year in the United States, which is similar to the number of malignant gliomas. Minnesota has one of the higher incidence rates of MDS. With the exception of chemotherapy and radiation treatment for other cancers, which is associated with < 5% of MDS, little is known about causes. Of the few studies conducted (mostly <200 cases and/or clinic-based), there is a suggestion of a role for occupational exposures, cigarette smoking, and some other lifestyle factors, many of which are similar to those associated with AML. We are proposing a new population-based study of MDS in Minnesota that utilizes the questionnaire and infrastructure of our ongoing adult myeloid leukemia study that concludes in early 2010. A total of 705 MDS cases and 705 frequency-matched population controls will be enrolled over a 4 1/2 year period (April 1, 2010 - October 31, 2014). In addition to evaluating potential risk factors such as those described above, we will explore risk factors by central pathology reviewed subtypes of MDS by integrating data from our adult myeloid leukemia study. We will also determine those environmental or other exogenous risk factors that are common to AML and MDS versus those risk factors that are distinct. Additionally, we will explore whether there are risk factors more common to MDS cases that are at risk of progressing to AML, which includes the novel incorporation of prognostic scoring systems. Finally, we will collect saliva from MDS cases and controls for future genetic susceptibility studies. This study will be the largest population-based study of MDS conducted to date. With the incorporation of a successful infrastructure, and the ability to make comparisons with a similar existing study of myeloid leukemia, we are uniquely positioned to answer important etiological questions regarding MDS. The significance of this proposal also relates to potential prevention strategies for adult AML, which has important public health implications.

描述（由申请人提供）：骨髓增生异常综合征 (MDS) 是造血系统的异质性破坏，约 1/3 的病例可导致急性髓系白血病 (AML) 的发展。 MDS 于 2001 年开始向监测、流行病学和最终结果计划报告。据估计，美国每年新诊断出约 10,000 例 MDS 病例，与恶性神经胶质瘤的数量相似。明尼苏达州是 MDS 发病率较高的州之一。除了与 < 5% 的 MDS 相关的其他癌症的化疗和放疗之外，人们对其病因知之甚少。在进行的少数研究（大多<200例和/或基于临床）中，有人建议职业暴露、吸烟和其他一些生活方式因素发挥作用，其中许多因素与 AML 相关。我们提议在明尼苏达州开展一项新的基于人群的 MDS 研究，该研究利用了我们正在进行的成人骨髓性白血病研究的问卷和基础设施，该研究将于 2010 年初结束。在一个为期 1 年的研究中，将招募总共 705 例 MDS 病例和 705 例频率匹配的人群对照。 4 1/2年期间（2010年4月1日至2014年10月31日）。除了评估上述潜在风险因素外，我们还将通过整合成人髓系白血病研究的数据，通过中心病理学审查 MDS 亚型来探索风险因素。我们还将确定 AML 和 MDS 共有的环境或其他外源性风险因素与独特的风险因素。此外，我们将探讨 MDS 病例是否存在更常见的风险因素，这些风险因素有进展为 AML 的风险，其中包括新纳入的预后评分系统。最后，我们将从 MDS 病例和对照中收集唾液，用于未来的遗传易感性研究。这项研究将是迄今为止进行的最大规模的 MDS 人群研究。凭借成功的基础设施以及与现有类似的髓系白血病研究进行比较的能力，我们在回答有关 MDS 的重要病因学问题方面处于独特的地位。该提案的重要性还涉及成人 AML 的潜在预防策略，这对公共卫生具有重要意义。