Brain Stimulation Core

脑刺激核心

• 批准号: 9904715
• 负责人: MARK S GEORGE
• 金额: $ 24.43万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9904715
• 关键词: Address; Animal Model; Animals; Behavior; Biological Markers; Biomedical Engineering; Brain; Centers of Research Excellence; Cervical; Clinical; Clinical Trials; Collaborations; Computer Models; Computer software; Data; Data Analyses; Data Collection; Data Set; Databases; Deep Brain Stimulation; Diagnostic; Discipline; Doctor of Philosophy; Educational workshop; Electroconvulsive Therapy; Environment; Equipment; Faculty; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Human; Human Resources; Injury; International; Intervention; Laboratories; Measurement; Measures; Mentors; Methodology; Methods; Motor; Nature; Outcome Measure; Periodicity; Phase; Physiologic pulse; Positioning Attribute; Protocols documentation; Rehabilitation therapy; Reproducibility; Research; Research Personnel; Resources; Role; Scientist; Services; Standardization; Techniques; Time; Training; Transcranial magnetic stimulation; Translating; Ultrasonography; United States National Institutes of Health; base; behavioral outcome; brain circuitry; experience; image guided; innovation; large datasets; method development; multidisciplinary; neuroimaging; neurophysiology; neuroregulation; novel; recruit; stroke recovery; success; theories; tool; treatment effect; treatment optimization; vagus nerve stimulation

The BSTIM Core provides access to state-of-the-art brain stimulation methods both to measure brain activity and to apply as a potential therapy to modify brain circuitry. During Phase I, BSTIM coalesced several brain stimulation laboratories at MUSC that now operate as a shared core resource. Phase II will enhance BSTIM’s stature as a premier resource in brain stimulation methods for neuromodulation and stroke recovery research. MUSC is one of few places where investigators can use transcranial magnetic stimulation within the scanner (interleaved TMS/fMRI) to directly examine the causal nature of induced activity in cortical and subcortical nodes of brain networks. The Director, Mark George, MD, is a recognized expert in the field. The Associate Director, Colleen Hanlon, PhD, is a Phase I COBRE graduate with experience integrating neuroimaging and brain stimulation techniques with behavioral outcomes to address fundamental questions about the brain’s ability to recover function following injury. COBRE funds will support a Bioengineer (shared with the NI Core) to oversee the technical aspects of the labs, maintain all equipment and develop new analysis routines; a full-time Research Technician to assist with neurophysiological data collection and neuromodulation protocols; and dedicated effort for experienced senior personnel to provide mentoring and methods development in brain stimulation techniques and measurements for human and animal studies. BSTIM has four aims: 1) Brain Stimulation for Assessment. Tools and services for assessment include basic TMS-measured neurophysiology (motor threshold, cortical silent period, paired pulse, and recruitment curves); image-guided stimulation; specialized approaches such as bi-hemispheric paired pulse TMS for transcallosal measurements and paired- associative stimulation (PAS) for measures of brain plasticity; and invasive and noninvasive brain stimulation in animal models. 2) Brain Stimulation for Rehabilitation. Tools and services include imaged-guided TMS and repetitive TMS inside or outside the scanner and transcranial direct current stimulation (tDCS) with computer models of the flow of current. The BSTIM Core can help researchers use other methods such as electroconvulsive therapy (ECT), non-invasive cervical or auricular vagus nerve stimulation (VNS), deep brain stimulation (DBS), epidural cortical stimulation, transcranial pulsed ultrasound, et al., as research progresses. 3) Theory-Based Outcome Measures. By continually developing innovative methodologies and analysis techniques, BSTIM will generate high quality, reproducible, quantitative data to help identify neurophysiological “biomarkers.” BSTIM will be a leader in forming large multi-system quantitative data sets for inclusion in the COBRE Comprehensive Multidisciplinary Database (CMD), and seek to become a leader in coalescing large data sets through leading or participating in national and international collaborations. 4) Mentoring. The goal of this aim is to nurture scientists skilled in the multiple domains necessary to investigate and exploit inherent plasticity and develop and translate novel mechanism-based, experience-dependent interventional methods.

BSTIM核心提供了对最新的脑模拟方法的访问，以测量大脑活动 并作为一种潜在的疗法来修饰脑电路。在第一阶段，BSTIM结合了几个大脑 MUSC的刺激实验室现在是共享的核心资源。第二阶段将增强BSTIM的 作为神经调节和中风恢复研究的大脑刺激方法的主要资源。 MUSC是研究人员可以在扫描仪内使用经颅磁刺激的地方之一 （交错的TMS/fMRI）直接检查皮质和皮质下诱导活性的因果 大脑网络的节点。导演马克·乔治（Mark George）医学博士是该领域的公认专家。同事 导演Colleen Hanlon博士是I期Cobre毕业生，具有整合神经成像和的经验 具有行为结果的大脑刺激技术，以解决有关大脑的基本问题 受伤后能够恢复功能。毛to基金将支持生物工程师（与NI Core共享） 监督实验室的技术方面，维护所有设备并开发新的分析程序；全职 研究技术人员协助神经生理数据收集和神经调节方案；和 专门为有经验的高级人员提供心理和方法发展的努力 人类和动物研究的刺激技术和测量。 Bstim有四个目标：1）大脑 刺激评估。评估工具和服务包括基本的TMS测量神经生理学 （运动阈值，皮质静音期，成对的脉冲和募集曲线）；图像引导的刺激； 专门的方法，例如用于触及度测量和配对的双性化配对脉冲TMS 用于测量脑可塑性的联想刺激（PAS）；以及侵入性和无创脑刺激 动物模型。 2）大脑刺激康复。工具和服务包括成像引导的TMS和 扫描仪内部或外部的重复TMS和trancranial Direct电流刺激（TDC）带有计算机 电流流的模型。 BSTIM核心可以帮助研究人员使用其他方法，例如 电抽搐治疗（ECT），非侵入性宫颈或耳神经刺激（VNS），深脑 随着研究的进展，刺激（DBS），硬膜外皮质刺激，经颅脉冲超声等。 3）基于理论的结果度量。通过不断开发创新的方法和分析 技术，BSTIM将产生高质量，可重现的定量数据，以帮助识别神经生理学 “生物标志物。” BSTIM将是形成大型多系统定量数据集的领导者 毛绒综合多学科数据库（CMD），并寻求成为融合大型的领导者 通过领导或参加国家和国际合作的数据集。 4）指导。目标 这个目的是护士熟练的科学家在调查和利用继承所必需的多个领域 可塑性并发展和翻译基于新型机制的经验依赖性介入方法。