Adult and Pediatric Nephrology Clinical Investigation Training Program

成人和儿童肾脏病临床研究培训计划

• 批准号: 9904612
• 负责人: Joachim H Ix
• 金额: $ 15.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9904612
• 关键词: Adult; Childhood; Nephrology; Training Programs; clinical investigation

 DESCRIPTION (provided by applicant): The objective of our T32 grant entitled is to rigorously train clinically oriented post-doctoral scholars from both adult and pediatric backgrounds in clinical investigation focused on prevention and treatment of kidney disease. The training program strives to supplying the workforce with outstanding clinical investigators in adult and pediatric nephrology who will lead the field in discovery of new treatments and preventive strategies for the expanding population of adult and pediatric kidney disease patients throughout their careers. The training will be provided through four structured modules, supplemented by elective coursework, seminars, and individual mentoring. The first module provides a 2-year mentored primary research project, supervised by a T32 faculty member and a 3-faculty Scholar Oversight Committee created individually for each scholar. This T32 places a strong emphasis on training in epidemiology and biostatistics, which will assist scholars regardless of their primary focus within clinical investigation. Thus, in the second module, all scholars will complete the UCSD CREST program; a highly rated and successful two-year Master's program in clinical research that is specifically designed to train clinically oriented scholars in research methods. Understanding the key aspects to measurement, including topics such as precision, limits of detection, and different platforms of measurement are key tools in clinical investigation. Moreover, skills to test the kidney's ability to metabolize and clear compounds will be necessary if scholars are to deliver new treatments to kidney disease patients. Thus, the third module is designed to provide the scholar hands-on experiences with in vivo pharmacology and measurement methods in both animal models and in humans. Finally, success in investigative careers requires skills in scientific writing, grantsmanship, and leadership; structured training i these areas is often overlooked. Thus, the fourth module will provide structured training in these areas. In proposing a new T32, we have specifically designed this grant with a modest request of post-doctoral fellow positions. We request 2 slots in year 1 and 3 slots in subsequent years. One in every 3 scholars will be trained in pediatric nephrology. Recognizing the importance of strong commitment of our faculty to a new T32, we have prioritized the quality and breadth of expertise of faculty, rather than quantity of faculty. The faculty was selected based on their commitment to clinical investigation, commitment to mentorship, and breadth of expertise in all aspects of clinical investigation spanning from physiology and pharmacology in animal models to clinical trials in humans. The scholar and faculty are supported by the great wealth of expertise of the larger faculty at UCSD which will be used to supplement needs of individual scholars. In aggregate, we propose an innovative, supportive environment for outstanding training in all aspects required for successful careers in clinical investigation in adult and pediatric nephrology.

 描述（由适用提供）：我们的T32赠款的目的是严格训练来自成人和儿科背景的临床临床注重后学者，以预防和治疗肾脏疾病。该培训计划致力于为成人和小儿肾脏病的杰出临床研究人员提供劳动力，他们将领导该领域，以发现新的治疗方法和预防策略，以促进整个职业生涯中成人和儿科肾脏疾病患者不断扩大的人群。该培训将通过四个结构化模块提供，并补充了选修课，半手赛和个人指导。第一个模块提供了一个为期2年的指导主要研究项目，该项目由T32教职员工和一个为每个学者单独创建的三名教职学者监督委员会监督。该T32非常重视流行病学和生物统计学的培训，这将有助于学者在临床研究中的主要重点。在第二个模块中，所有学者将完成 UCSD Crest计划；一项高度评​​价且成功的为期两年的临床研究硕士课程，专门设计用于培训临床导向学者的研究方法。了解测量值的关键方面，包括精度，检测限制和不同测量平台等主题是临床研究的关键工具。此外，如果学者要向肾脏病患者提供新的治疗方法，则需要测试肾脏代谢和清除化合物的能力的技能。这是第三个模块旨在为动物模型和人类中的体内药理学和测量方法提供动手体验。最后，在调查职业中取得成功需要科学写作，授予技巧和领导才能；结构化训练I经常被忽视。这是第四个模块将在这些领域提供结构化培训。在提案中，新的T32，我们专门设计了这笔赠款，并提出了大量的博士后职位。我们在后期的第1年和3个插槽中要求2个插槽。每3个学者中有1个将接受儿科肾脏的培训。认识到我们教师对新T32的坚定承诺的重要性，我们优先考虑教师的质量和广度，而不是教师的数量。该教师是根据他们对临床投资，对心态的承诺以及在临床投资各个方面的专业知识的承诺而选择的，这些方面涉及动物模型的生理学和药物到人类的临床试验。科学和教职员工得到了UCSD较大教师的丰富专业知识的支持，这些专业知识将用于补充各个学者的需求。总体而言，我们为成人和小儿肾脏病临床研究所需的各个方面的各个方面提供了一个创新的支持环境。

项目成果

Flank pain and gross hematuria: an uncommon presentation of a rare disease: Answers.

胁腹痛和肉眼血尿：罕见疾病的罕见表现：答案。

• DOI: 10.1007/s00467-020-04900-0
• 发表时间: 2021
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Allred,ErikaT;Yorgin,PeterD
• 通讯作者: Yorgin,PeterD

Flank pain and gross hematuria: an uncommon presentation of a rare disease: Questions.

• DOI: 10.1007/s00467-020-04889-6
• 发表时间: 2021-07
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Allred ET;Yorgin PD
• 通讯作者: Yorgin PD

De Novo Postinfectious Glomerulonephritis Secondary to Nephritogenic Streptococci as the Cause of Transplant Acute Kidney Injury: A Case Report and Review of the Literature.

• DOI: 10.1155/2018/2695178
• 发表时间: 2018
• 期刊: Case reports in transplantation
• 作者: Bullen A;Shah MM
• 通讯作者: Shah MM