Midcareer Investigator Award: Metabolic Complications of Chronic Kidney Disease

职业生涯中期研究员奖：慢性肾脏病的代谢并发症

• 批准号: 9901518
• 负责人: BRYAN R KESTENBAUM
• 金额: $ 12.68万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901518
• 关键词: Adult; African American; Applications Grants; Appointment; Arteriovenous fistula; Award; Biological Assay; Biometry; Cardiology; Cardiovascular system; Catabolism; Characteristics; Chronic Kidney Failure; Clinical; Clinical Research; Cohort Studies; Data; Data Analyses; Disease Progression; Dose; Drug Kinetics; Educational process of instructing; Environment; Enzymes; Epidemiologist; Epidemiology; Event; Faculty; Failure; Fistula; Funding; Future; Glomerular Filtration Rate; Grant; Hemodialysis; Imaging Device; Individual; Infrastructure; K-Series Research Career Programs; Kidney; Kidney Diseases; Kidney Failure; Knowledge; Lead; Mass Spectrum Analysis; Measures; Medicine; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolism; Methodology; Minerals; Mitochondria; Muscle Mitochondria; Nephrology; Operative Surgical Procedures; Paper; Patients; Pharmaceutical Preparations; Physical Performance; Physicians; Positioning Attribute; Property; Publishing; Quality of life; Renal function; Research; Research Institute; Research Personnel; Research Support; Risk Factors; Scientist; Secure; Skeletal Muscle; Staging; Testing; Time; Training; Training Programs; Translating; Translational Research; Universities; Variant; Vascular Diseases; Washington; Work; career; cohort; design; disability; exercise training; experience; functional independence; graduate student; hands on research; improved; interest; medical schools; meetings; metabolic abnormality assessment; next generation; novel; patient oriented research; programs; public health relevance; skills; solute; success

 DESCRIPTION (provided by applicant): Throughout my research career I have I cultivated a passion for mentoring clinical researchers in Nephrology, Epidemiology, and Biostatistics. I have translated this passion into action, as the director of an established and successful clinical research group that integrates physicians, Epidemiologists, and Biostatisticians toward the study of chronic kidney disease, and as chair of the University of Washington Medical School Epidemiology course. My previous research trainees have published extensively during their training period, obtained career development awards, and secured faculty positions in academic medicine. I am applying for this K24 grant to secure the protected time necessary to implement a comprehensive clinical research training program designed to equip the next generation of researchers with vital methodological skills and hands-on research experiences necessary for them to obtain independent funding and achieve long-term success. I will mentor physician-scientists and graduate students in Epidemiology and Biostatistics, who will work together to solve clinical research problems in chronic kidney disease. Trainees will work within the dedicated environment of the Kidney Research Institute (KRI), a kidney-specialized, clinical and translational research unit that provides key infrastructure and support for patient-oriented research.

 描述（由适用提供）：在我的研究生涯中，我培养了对肾脏科学，流行病学和生物统计学方面的心理临床研究人员的热情。我已经将这种激情转化为行动，是一个成熟且成功的临床研究小组的主任，该小组将医生，流行病学家和生物统计学家整合到慢性肾脏病研究的研究中，并担任华盛顿大学医学院流行病学课程的主席。我以前的研究学员在培训期间已经广泛发表，获得了职业发展奖，并确保了学术医学领域的职位。我正在申请这项K24赠款，以确保实施一项全面的临床研究培训计划所需的受保护时间，旨在为下一代研究人员提供重要的方法论技巧和动手研究经验，以获得独立资金并取得长期成功。我将在流行病学和生物统计学领域进行精神身体科学家和研究生，他们将共同解决慢性肾脏疾病的临床研究问题。学员将在肾脏研究所（KRI）的专用环境中工作，肾脏研究所（KRI）是一个肾脏专业，临床和翻译研究部门，为以患者为导向的研究提供关键的基础设施和支持。

项目成果

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study.

• DOI: 10.1186/s13054-021-03547-z
• 发表时间: 2021-04-19
• 期刊: Critical care (London, England)
• 作者: Bhatraju PK;Morrell ED;Zelnick L;Sathe NA;Chai XY;Sakr SS;Sahi SK;Sader A;Lum DM;Liu T;Koetje N;Garay A;Barnes E;Lawson J;Cromer G;Bray MK;Pipavath S;Kestenbaum BR;Liles WC;Fink SL;West TE;Evans L;Mikacenic C;Wurfel MM
• 通讯作者: Wurfel MM

Urinary Concentration Ability: Time to Bring the Tubules to the Table.

尿液浓缩能力：将小管带到餐桌上的时间。

• DOI: 10.1053/j.ajkd.2019.01.019
• 发表时间: 2019
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Wang,Ke;Kestenbaum,Bryan
• 通讯作者: Kestenbaum,Bryan