Functions of the thalamus in attention and perception

丘脑在注意力和感知方面的功能

• 批准号: 9899995
• 负责人: SABINE KASTNER
• 金额: $ 41.01万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899995
• 关键词: Anatomy; Area; Attention; Attention deficit hyperactivity disorder; Attentional deficit; Behavior; Behavioral; Binding; Cell Nucleus; Cell physiology; Cognition; Cognitive; Communication; Data; Decision Making; Dorsal; Electrophysiology (science); Frequencies; Functional Magnetic Resonance Imaging; Funding; Grant; Health; Human; Impairment; Individual; Inferior; Investigation; Lateral; Lesion; Macaca; Medial; Memory; Mental disorders; Methods; Microelectrodes; Monkeys; Neurons; Output; Parietal; Parietal Lobe; Pattern; Perception; Population; Population Dynamics; Positioning Attribute; Primates; Property; Public Health; Pulvinar structure; Research; Resolution; Role; Schizophrenia; Site; Statistical Data Interpretation; Stroke; Techniques; Thalamic Nuclei; Thalamic structure; Time; Training; Visual; Visual Cortex; Visuospatial; Work; area V4; attentional control; attentional modulation; behavior measurement; cell type; cognitive ability; cognitive function; cognitive neuroscience; cognitive process; directed attention; effective therapy; extrastriate visual cortex; innovation; multimodality; neglect; nervous system disorder; neural correlate; neuroimaging; neuromechanism; operation; post stroke; relating to nervous system; response; selective attention; sensory cortex; transmission process; treatment strategy

The visual thalamus has been extensively studied in terms of its anatomical organization, connectivity patterns, and basic neural response properties. However, its role in perception and cognition has remained poorly understood. The present application is a competing renewal submission for our grant “Functions of the thalamus in perception and cognition” (RO1-EY017699). Work during the previous funding period has (i) characterized the topographic organization and functional response properties of the human pulvinar using high-resolution functional magnetic resonance imaging (fMRI) and (ii) defined a functional role of the macaque pulvinar in spatial selective attention using simultaneous multi-site recordings. The present application extends this work to investigate a causal role for the macaque pulvinar in attentional control. The pulvinar is the largest nucleus in the primate thalamus and is considered a higher-order thalamic nucleus, because it forms input- output loops almost exclusively with the cortex. From an anatomical perspective, the pulvinar is ideally positioned to regulate the transmission of information to the cortex and between cortical areas to influence perceptual and cognitive processes. Evidence from lesion studies in humans and monkeys demonstrate a critical involvement of the pulvinar in a number of fundamental cognitive functions, including orienting responses and the exploration of visual space, the filtering of unwanted information, and visually-guided behavior. Our studies during the last funding cycle have begun to establish neural correlates that may underlie some of these cognitive functions. We showed that the indirect pulvino-cortical connectivity appears to facilitate information transfer between areas in visual cortex. The proposed project will extend this work by probing the hypothesis that the pulvinar is an integral subcortical part of a large-scale attentional control network. Using a multi-modal methods approach that includes simultaneous multi-site recordings, neuroimaging, and reversible inactivation in monkeys trained on an Eriksen flanker task, we will pursue three specific aims. First, we will systematically characterize attentional modulation and functional interactions across pulvinar subdivisions by simultaneously recording from dozens of single- and multi-units using linear microelectrode arrays. Second, we will probe the idea that the pulvinar coordinates interactions within the fronto-parietal attention control network, thus acting as a temporal coordinator, by simultaneously recording from FEF, LIP and their interconnected projection zone in dorsal pulvinar. And third, we will probe a causal role for the pulvinar in attentional control. By reversibly inactivating dorsal pulvinar under MR-guidance and performing simultaneous recordings from FEF and LIP in our spatial attention task we will investigate local effects and interactions across the fronto- parietal network in relation to behavior. The significance of the proposed research is that it will further our understanding of the functions of thalamo-cortical interactions in perception and cognition using an innovative approach that combines cutting edge neuroimaging techniques with intracranial electrophysiology.

视觉丘脑的解剖组织、连接模式、 然而，它在感知和认知中的作用仍然很差。 据了解，本申请是针对我们的赠款“职能”的竞争性续展提交。 丘脑在知觉和认知中的作用”（RO1-EY017699）。上一个资助期间的工作有（i）。 使用人类pulvinar的地形组织和功能反应特性来表征 高分辨率功能磁共振成像（fMRI）和（ii）定义了猕猴的功能作用 pulvinar 使用同时多站点记录扩展了空间选择性注意。 这项工作旨在研究猕猴 pulvinar 在注意力控制中的因果作用。 pulvinar 是最大的。 灵长类丘脑中的核，被认为是高级丘脑核，因为它形成输入- 从解剖学的角度来看，脑枕是理想的输出回路。 定位于调节信息到皮层以及皮层区域之间的传输，以影响 来自人类和猴子的病变研究的证据表明 枕骨对许多基本认知功能的重要参与，包括定向 视觉空间的反应和探索、过滤不需要的信息以及视觉引导 我们在上一个资助周期中的研究已经开始建立可能存在的神经关联。 我们发现间接的枕皮质连接似乎可以促进其中一些认知功能。 拟议的项目将通过探测视觉皮层区域之间的信息传递来扩展这项工作。 假设枕丘是大规模注意力控制网络的一个不可或缺的皮层下部分。 多模式方法，包括同时多位点记录、神经成像和可逆 在接受埃里克森侧翼任务训练的猴子中进行失活，我们将追求三个具体目标。 通常通过 pulvinar 细分来表征注意力调节和功能相互作用 使用线性微电极阵列同时记录数十个单个和多个单元。 将探讨枕丘协调额顶叶注意力控制网络内相互作用的想法， 因此，通过同时从 FEF、LIP 及其互连进行记录，充当时间协调器 第三，我们将探讨脑枕在注意力控制中的因果作用。 通过在 MR 引导下可逆地灭活背侧枕丘并执行同步记录 FEF 和 LIP 在我们的空间注意力任务中，我们将研究整个额叶的局部效应和相互作用 顶叶网络与行为的关系所提出的研究的意义在于它将进一步推动我们的研究。 使用创新的方法了解丘脑皮质相互作用在感知和认知中的功能 将尖端神经影像技术与颅内电生理学相结合的方法。