ShEEP Request for FUJIFILM VisualSonics Vevo 3100 Imaging System

ShEEP 请求 FUJIFILM VisualSonics Vevo 3100 成像系统

• 批准号: 9905989
• 负责人: SUBBURAMAN MOHAN
• 金额: --
• 依托单位: VA LOMA LINDA HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905989
• 关键词: Adult; Affect; Aminoglycosides; Animal Experimentation; Animals; Applications Grants; Area; Audiology; Biomedical Research; Body Temperature; Bone callus; Brain; Cells; Cochlea; Data; Data Quality; Defect; Degenerative polyarthritis; Development; Disease; Disease Progression; Electrocardiogram; Embryo; Endothelium; Ephrins; Equipment; Fracture; Frequencies; Funding; Genes; Genetic; Genetic Materials; Grant; Health; Healthcare Systems; Heart; Heart Rate; Heterotopic Ossification; Image; Inflammation; Inflammatory; Injections; Injury; Investigation; Joints; Laboratories; Labyrinth; Left; Life Style; Longitudinal Studies; Measurement; Measures; Medical center; Military Personnel; Minor; Mission; Mole the mammal; Monitor; Morphologic artifacts; Mus; Muscle; Musculoskeletal; Needles; Operative Surgical Procedures; Organ; Oryctolagus cuniculus; Osteoporosis; Pathogenesis; Pharmaceutical Preparations; Phase; Phosphotransferases; Physiologic Monitoring; Physiological; Rattus; Research; Research Personnel; Resolution; Respiration; Services; Sheep; Site; Skeleton; Small Animal Imaging Systems; Synovial Membrane; System; Techniques; Technology; Testing; Therapeutic; Time; Tissues; Transducers; Traumatic Brain Injury; Ultrasonography; United States National Institutes of Health; Universities; Ventricular; Veterans; Work; angiogenesis; articular cartilage; base; bone; chemokine; clinical investigation; cost efficient; data acquisition; design; healing; hearing impairment; high risk; high throughput analysis; image guided; image processing; imaging modality; imaging platform; imaging system; improved; inhibitor/antagonist; instrument; interest; middle ear; mouse model; non-invasive imaging; novel; ototoxicity; pre-clinical; real-time images; response; restoration; round window; service member; skeletal; small molecule; small molecule inhibitor

In this ShEEP grant, we request funds to purchase a high frequency ultrasound imaging system (Vevo 3100) manufactured by FUJIFILMS VisualSonics to specifically image small animals such as mice, rat and rabbits. The ultrasound-based techniques are increasingly being used for pre-clinical investigations. The Vevo 3100 system will be equipped with a linear phased array ultrasound probe specific for small animals and also has several upgrades in the ultrasound technology including; 1) improved resolution, 2) reduced artifact, 3) real time image processing, 4) left ventricular tracing, 5) improved workflow for rapid data acquisition, 6) speckle tracking analysis (for strain analysis), 7) an imaging station equipped with injection mount (for echo guided tissue injections), and 8) a high throughput analysis. This new instrument will be used by a number of investigators at the VALLHCS to perform small animal high frequency ultrasound imaging work. The non-invasive imaging modalities available in the Vevo 3100 system will allow applications that include imaging of soft and hard tissues, monitoring developmental defects in various organs including heart, brain and muscle in mice with targeted disruption of genes of interest, perform measures related to angiogenesis and inflammation, and guided injections of therapeutic moles at sites of interest. The Vevo 3100 system will permit repeated serial measurements in longitudinal studies, thereby permitting more robust statistical assessment and limiting the number of animals needed for the studies. A number of VA, DOD and NIH funded investigators at this VA Medical Center including Drs. Mohan, Lau, Rundle, Dong, Xing, Li and Edderkaoui will benefit from being able to use this equipment to perform studies related to their funded grant applications. Currently, no ultrasound imaging system for small animals is available for research use at VALLHCS. The requested instrument will greatly enhance experimental capabilities of small animal research that are relevant to the pathogenesis and treatment of osteoporosis, osteoarthritis and hearing loss, diseases that are target areas of the VA research mission.

在这项 ShEEP 拨款中，我们请求资金购买高频超声成像设备 FUJIFILMS VisualSonics 制造的系统 (Vevo 3100)，专门用于小尺寸成像 动物，例如小鼠、大鼠和兔子。基于超声的技术正日益被 用于临床前研究。 Vevo 3100 系统将配备线性相控 专门针对小动物的阵列超声探头，在超声方面也有多项升级 技术包括； 1) 提高分辨率，2) 减少伪影，3) 实时图像处理， 4) 左心室追踪，5) 改进的快速数据采集工作流程，6) 散斑追踪 分析（用于应变分析），7）配备注射支架的成像站（用于回波引导 组织注射），8）高通量分析。这种新仪器将被许多人使用 VALLHCS 的研究人员进行小动物高频超声成像工作。 Vevo 3100 系统中可用的非侵入性成像模式将允许应用 包括软组织和硬组织成像、监测各种器官的发育缺陷 包括小鼠的心脏、大脑和肌肉，有针对性地破坏感兴趣的基因，执行 与血管生成和炎症相关的措施以及治疗性痣的引导注射 在感兴趣的地点。 Vevo 3100 系统将允许重复连续测量 纵向研究，从而允许更稳健的统计评估并限制 研究所需的动物数量。许多 VA、DOD 和 NIH 资助的研究人员 在这个退伍军人管理局医疗中心，包括博士。 Mohan、Lau、Rundle、Dong、Xing、Li 和 Edderkaoui 将 受益于能够使用该设备进行与其资助的赠款相关的研究 应用程序。目前尚无小动物超声成像系统可供研究 在 VALLHCS 使用。所要求的仪器将大大提高实验能力 与骨质疏松症发病机制和治疗相关的小动物研究， 骨关节炎和听力损失等疾病是退伍军人管理局研究任务的目标领域。