Impaired sensorimotor integration for prosodic production in Ataxic Dysarthria

共济失调性构音障碍韵律产生的感觉运动整合受损

• 批准号: 9900146
• 负责人: Allison I Hilger
• 金额: $ 3.04万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900146
• 关键词: Accent; Acoustics; Affect; Articulation; Auditory; Auditory pitch; Cerebellar Diseases; Cerebellum; Disease; Doctor of Philosophy; Dysarthria; Ensure; Environment; Exhibits; Feedback; Future; Gait; Goals; Impairment; Individual; Loudness; Measures; Mentorship; Mission; Motor; Movement; Muscle; Musculoskeletal Equilibrium; Pattern; Process; Production; Property; Public Health; Reflex action; Research; Role; Scientist; Speech; Speech Intelligibility; Speech Therapy; Stress; Structure; System; Techniques; Testing; Translational Research; United States National Institutes of Health; Voice; arm movement; auditory feedback; base; career; cerebellar lesion; disability; effective therapy; improved; phrases; predicting response; relating to nervous system; response; sensory feedback; sensory integration; sensory mechanism; skills; somatosensory; sound; success; tool; vocalization

Project Summary/Abstract Although the role of the cerebellum for the smooth and coordinated execution of movement is generally understood, little is known about how the cerebellum facilitates speech movement for natural and accurate prosodic production.3 Individuals with ataxic dysarthria due to a cerebellar damage exhibit atypical prosodic patterns, including a monotone vocal quality, a variable rate of speech, and atypical phrasal stress patterns.6,7 Our objectives are to measure the differences in reflexive and predictive voice responses between speakers with and without ataxic dysarthria to provide indicators of the accuracy of the cerebellum for the integration of sensory feedback with motor plans for speech. The rational for this study is that atypical prosody disrupts speech naturalness and intelligibility which current speech therapy approaches are not effective in fully restoring due to a poor understanding of the underlying impairment. The long-term goal is to characterize the deficits in sensorimotor integration in ataxic dysarthria to better understand the underlying mechanism for prosodic impairment. The central hypothesis of this project is that prosody in ataxic dysarthria is impaired because of a diminished ability to integrate sensory feedback with (i) prior motor plans for speech, affecting reflexive corrective mechanisms for intonation, as well as (ii) future motor plans for speech, affecting predictive scaling mechanisms for adjusting downstream intonational targets. This hypothesis will be tested by perturbing voice pitch auditory feedback of speakers with and without ataxic dysarthria to compare reflexive and predictive vocal responses in sustained vocalization and in anticipatory f0 changes. The differences in responses between speakers with and without ataxic dysarthria will provide indicators of the accuracy of the cerebellum in incorporating sensory feedback with online speech production. More specifically, the following aims will be measured: 1) measure the reflexive vocal response mechanism to examine sensorimotor integration with prior motor plans, and 2) measure the predictive vocal scaling mechanism to examine sensorimotor integration with future motor plans of downstream intonation targets. These two aims were derived from evidence of impairments to reflexive and anticipatory control of posture, gait, and arm movement in response to movement displacements in individuals with cerebellar lesions.15–17 The same disrupted cerebellar functions for movement may underlie the atypical prosodic patterns in speech. The proposed research is significant because it is expected to provide a greater understanding of the underlying cerebellar mechanism of the prosodic impairment in ataxic dysarthria so that effective therapy treatments can be developed to improve speech intelligibility and naturalness. Additionally, these results will provide clarity of the cerebellum's involvement in the speech production process for feedback integration with motor plans for speech.

项目摘要/摘要 尽管小脑在流动的平稳执行方面的作用通常是 了解，关于小脑女主人语音运动的自然和准确方式知之甚少 韵律生产。3由于附加症损害暴露于非典型韵律造成的均质构障碍的人 模式，包括单调的人声质量，可变的语音速率和非典型的戏剧应力模式。6,7 我们的目标是衡量说话者之间反身和预测性语态反应的差异 并且没有共济失调的构音障碍，可以提供小脑准确性的指标 带有演讲计划的反馈。这项研究的理性是非典型韵律破坏了语音 自然性和智力当前的语音疗法方法在完全恢复中无效 对潜在障碍的不良理解。长期目标是表征 在共同构音障碍中的感觉运动整合，以更好地了解韵律的潜在机制 损害。该项目的核心假设是，由于一个 将感官反馈与（i）先前的语音运动计划相结合的能力降低，影响反思纠正措施 语调的机制，以及（ii）未来的演讲计划，影响预测缩放机制 用于调整下游独立目标。该假设将通过扰动语音音调听觉来检验 具有和没有共济失调构音障碍的说话者的反馈，以比较反思性和预测性的人声反应 持续发声和预期的F0变化。与和 没有共济失调构音障碍将提供小脑在编码感觉中准确性的指标 通过在线语音制作的反馈。更具体地说，将测量以下目标：1）测量 反身人声响应机制检查具有先前电机计划的感觉运动积分，2）测量 预测性声缩放机制，以检查感觉运动集成与未来的电动机计划的集成 下游语调目标。这两个目的源自对反射性损害的证据和 响应个人运动位移的姿势，AIT和手臂运动的预期控制 15–17相同的小脑功能可用于运动，这可能是非典型的，这可能是非典型的 语音中的韵律模式。拟议的研究很重要，因为它有望提供更大的 理解共济质心障碍中韵律障碍的潜在小脑机制，以便 可以开发有效的治疗疗法以提高语音清晰度和自然性。此外， 这些结果将清楚小脑参与语音生产过程的反馈 与运动计划的整合。