Impaired sensorimotor integration for prosodic production in Ataxic Dysarthria

共济失调性构音障碍韵律产生的感觉运动整合受损

• 批准号: 9900146
• 负责人: Allison I Hilger
• 金额: $ 3.04万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900146
• 关键词: Accent; Acoustics; Affect; Articulation; Auditory; Auditory pitch; Cerebellar Diseases; Cerebellum; Disease; Doctor of Philosophy; Dysarthria; Ensure; Environment; Exhibits; Feedback; Future; Gait; Goals; Impairment; Individual; Loudness; Measures; Mentorship; Mission; Motor; Movement; Muscle; Musculoskeletal Equilibrium; Pattern; Process; Production; Property; Public Health; Reflex action; Research; Role; Scientist; Speech; Speech Intelligibility; Speech Therapy; Stress; Structure; System; Techniques; Testing; Translational Research; United States National Institutes of Health; Voice; arm movement; auditory feedback; base; career; cerebellar lesion; disability; effective therapy; improved; phrases; predicting response; relating to nervous system; response; sensory feedback; sensory integration; sensory mechanism; skills; somatosensory; sound; success; tool; vocalization

Project Summary/Abstract Although the role of the cerebellum for the smooth and coordinated execution of movement is generally understood, little is known about how the cerebellum facilitates speech movement for natural and accurate prosodic production.3 Individuals with ataxic dysarthria due to a cerebellar damage exhibit atypical prosodic patterns, including a monotone vocal quality, a variable rate of speech, and atypical phrasal stress patterns.6,7 Our objectives are to measure the differences in reflexive and predictive voice responses between speakers with and without ataxic dysarthria to provide indicators of the accuracy of the cerebellum for the integration of sensory feedback with motor plans for speech. The rational for this study is that atypical prosody disrupts speech naturalness and intelligibility which current speech therapy approaches are not effective in fully restoring due to a poor understanding of the underlying impairment. The long-term goal is to characterize the deficits in sensorimotor integration in ataxic dysarthria to better understand the underlying mechanism for prosodic impairment. The central hypothesis of this project is that prosody in ataxic dysarthria is impaired because of a diminished ability to integrate sensory feedback with (i) prior motor plans for speech, affecting reflexive corrective mechanisms for intonation, as well as (ii) future motor plans for speech, affecting predictive scaling mechanisms for adjusting downstream intonational targets. This hypothesis will be tested by perturbing voice pitch auditory feedback of speakers with and without ataxic dysarthria to compare reflexive and predictive vocal responses in sustained vocalization and in anticipatory f0 changes. The differences in responses between speakers with and without ataxic dysarthria will provide indicators of the accuracy of the cerebellum in incorporating sensory feedback with online speech production. More specifically, the following aims will be measured: 1) measure the reflexive vocal response mechanism to examine sensorimotor integration with prior motor plans, and 2) measure the predictive vocal scaling mechanism to examine sensorimotor integration with future motor plans of downstream intonation targets. These two aims were derived from evidence of impairments to reflexive and anticipatory control of posture, gait, and arm movement in response to movement displacements in individuals with cerebellar lesions.15–17 The same disrupted cerebellar functions for movement may underlie the atypical prosodic patterns in speech. The proposed research is significant because it is expected to provide a greater understanding of the underlying cerebellar mechanism of the prosodic impairment in ataxic dysarthria so that effective therapy treatments can be developed to improve speech intelligibility and naturalness. Additionally, these results will provide clarity of the cerebellum's involvement in the speech production process for feedback integration with motor plans for speech.

项目概要/摘要 尽管小脑对于平稳和协调地执行运动的作用通常是 据了解，人们对小脑如何促进自然而准确的言语运动知之甚少 韵律产生。3 由于小脑损伤而患有共济失调性构音障碍的个体表现出非典型韵律 模式，包括单调的声音质量、可变的语速和非典型的短语重音模式。6,7 我们的目标是衡量说话者之间反射性和预测性语音响应的差异 并且没有共济失调性构音障碍，为小脑感觉统合的准确性提供指标 言语运动计划的反馈 这项研究的理由是非典型韵律会扰乱言语。 目前的言语治疗方法无法有效地完全恢复自然性和可理解性，因为 对潜在损害的了解不足。长期目标是描述赤字的特征。 共济失调构音障碍的感觉运动整合，以更好地理解韵律的潜在机制 该项目的中心假设是共济失调性构音障碍的韵律因以下原因而受损。 将感觉反馈与（i）先前的言语运动计划整合的能力减弱，影响反射性纠正 语调机制，以及 (ii) 未来的言语运动计划，影响预测建模机制 为了将下游调整到国家目标，该假设将通过扰动音调听觉进行测试。 患有和不患有共济失调性构音障碍的说话者的反馈，以比较反射性和预测性声音反应 持续发声和预期 f0 变化的说话者之间的反应差异。 没有共济失调性构音障碍将提供小脑整合感觉准确性的指标 更具体地说，将衡量以下目标：1）衡量 反射性声音反应机制，用于检查感觉运动与先前运动计划的整合，以及 2) 测量 预测声音缩放机制，用于检查感觉运动与未来运动计划的整合 这两个目标源自反射和语调损伤的证据。 根据个体的运动位移对姿势、步态和手臂运动进行预期控制 伴有小脑病变。15–17 同样的小脑运动功能紊乱可能是非典型的基础 所提出的研究很重要，因为它有望提供更大的帮助。 了解共济失调性构音障碍韵律障碍的潜在小脑机制 可以开发有效的治疗方法来提高言语清晰度和自然度。 这些结果将清楚地表明小脑参与言语产生过程的反馈 与语音运动计划集成。