Gut microbiota, inflammation, and adolescent depressive symptoms

肠道微生物群、炎症和青少年抑郁症状

基本信息

批准号：
9770566
负责人：
Cherry Leung
金额：
$ 8.7万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-11 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9770566
关键词：
Adolescent Adult Affect Age Antibiotics Award Bacteria Bifidobacterium Bioinformatics Biological Biological Markers California Caring Clinical Research Collection Communities Conflict (Psychology)Cross-Sectional Studies Development Diagnosis Diet Environment Environmental Risk Factor Future Genetic Materials High Prevalence Homeostasis Immune Individual Inflammation Inflammatory Interleukin-1 beta Interleukin-6 Intestines Knowledge Lactobacillus Learning Literature Longitudinal Studies Mediating Mental Depression Mental Health Mentored Research Scientist Development Award Mentors Mentorship Methods Microbe Parasites Participant Pathogenicity Pathway interactions Pediatric Nursing Play Population Predisposition Prevalence Prevention Probiotics Process Public Health Recommendation Reporting Research Research Personnel Risk Factors Role San Francisco Severities Symptoms System TNF gene Taxon Taxonomy Training Universities Virus Yeasts adolescent health beta diversity career development child depression cohort cytokine depressive symptoms design dysbiosis experience fungus gut microbes gut microbiome gut microbiota gut-brain axis microbial microbiota multidisciplinary pathogenic bacteria primary care setting programs recruit research study skills

项目摘要

PROJECT SUMMARY/ABSTRACT The candidate, who has a strong background in pediatric nursing and public health, seeks to become an independent researcher in adolescent health with a focus on the influences of the gut microbiota (the microbes in the intestine) on adolescent depressive symptoms. Adolescent depression is a worldwide phenomenon, with 3% to 5% of adolescents diagnosed with depression. The prevalence of adolescents with depressive symptoms is even higher, estimated at 7% to 28%, so it is crucial to identify the associated risk factors. The gut microbiota may be involved in mechanisms underlying the modulation of adolescent depressive symptoms. This proposal seeks to elucidate the processes of the gut-brain axis, including the mediating role of the immune pathway. The K01 Mentored Research Scientist Development Award will provide the necessary support and training to the candidate to establish a program of research that aspires to promote adolescent health by reducing risk factors for adolescent depressive symptoms. The proposed study will examine an understudied risk factor, the disruption of the gut microbiota. Support and training through the K01 will aid in accomplishing several specific aims: Aim 1 - characterize the gut microbiota of adolescents, Aim 2 - determine whether severity of depressive symptoms is associated with the diversity of gut microbiota composition, Aim 3 - determine if severity of depressive symptoms is associated with lower levels of beneficial bacteria and higher levels of pathogenic bacteria, and Aim 4 - determine whether inflammatory cytokines mediate the relationship between depressive symptoms and levels of beneficial or pathogenic bacteria. The proposed mentored research plan includes individual mentorship, specialized training, and coursework to: 1) design and conduct clinical studies aimed at examining biological risk factors of depressive symptoms, and 2) learn and apply specialized bioinformatics methods to analyze and interpret the gut microbiota. Dr. Leung will manage and conduct a cross-sectional study from project design to completion with a multi-disciplinary group of mentors at the University of California, San Francisco. Dr. Sandra Weiss, who has extensive experience with research studies focusing on adolescent health, biomarkers and depression, will provide overall direction and mentorship. Dr. Susan Lynch will provide mentorship in microbiota collection and analysis. Lastly, Dr. Mark Rubinstein will provide additional training in recruiting, tracking and maintaining adolescent participants. The proposed career development activities and research will provide the knowledge, skills, and experience that will culminate in Dr. Leung’s successful application for a R01 award to independently conduct a longitudinal study to further examine the gut microbiome, the genetic material of the microbes that inhabit the gut community, and immune pathways associated with adolescent depressive symptoms.

项目摘要/摘要候选人在儿科护士和公共卫生方面具有强大的背景，他试图成为青少年健康的独立研究人员，重点是肠道菌群的影响（微生物在肠道上）青春期抑郁症状。青春期抑郁症是一种全球现象， 3％至5％的青少年被诊断出患有抑郁症。抑郁症青少年的患病率症状甚至更高，估计为7％至28％，因此确定相关的危险因素至关重要。肠道微生物群可能参与了青少年抑郁症状调节的基础机制。该建议旨在阐明肠道轴的过程，包括免疫途径。 K01指导研究科学家发展奖将提供必要的对候选人的支持和培训，以建立渴望促进青少年的研究计划通过减少青少年抑郁症状的危险因素的健康。拟议的研究将检查理解危险因素，即肠道菌群的破坏。支持和通过K01进行训练将有助于完成几个具体目标：目标1-表征肠道微生物群青少年的目标2-确定抑郁症状的严重程度是否与多样性有关肠道菌群组成，目标3-确定抑郁症状的严重程度是否与较低有关有益细菌和较高水平的致病细菌水平，目标4-确定是否是否炎性细胞因子介导抑郁症状与有益水平之间的关系致病细菌。拟议的讨论研究计划包括个人备票，专业培训和课程： 1）设计和进行临床研究，旨在检查抑郁符号的生物危险因素， 2）学习并应用专门的生物信息学方法来分析和解释肠道菌群。 Leung博士将通过多学科管理和进行从项目设计到完成的横断面研究加州大学旧金山分校的导师小组。桑德拉·魏斯（Sandra Weiss）博士，他的广泛研究专注于青少年健康，生物标志物和抑郁症的研究经验将提供整体方向和心态。苏珊·林奇（Susan Lynch）博士将在Microbiota收集和分析中提供心态。最后，马克·鲁宾斯坦（Mark Rubinstein）博士将在招募，跟踪和维护青少年方面提供额外的培训参与者。拟议的职业发展活动和研究将提供知识，技能和经验将最终导致Leung成功申请R01奖，以独立进行一项纵向研究，以进一步检查肠道微生物组，这是影响影响的微生物的遗传物质肠道社区和与青少年抑郁症状相关的免疫途径。