Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools

非人类灵长类动物体细胞基因组编辑工具评估测试中心

基本信息

批准号：
9770048
负责人：
DAVID J SEGAL
金额：
$ 116.87万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9770048
关键词：
Address Animal Model Animal Testing Animals Benchmarking Biological Assay California Callithrix Center for Translational Science Activities Clinical Sciences Collaborations Communication Communities Development Ensure Evaluation Feedback Fostering Funding Future Genome Goals Governing Board Home environment Human Inflammation Infrastructure Leadership Macaca mulatta Methodology Modeling Office of Administrative Management Population Positioning Attribute Primates Procedures Process Publications Reagent Reporter Research Research Personnel Resources Safety Schedule Scientist Specificity System Technology Testing Translations United States National Institutes of Health Universities Work base data exchange experience genome editing human disease immunogenicity in vivo innovation meetings member multidisciplinary nonhuman primate organizational structure programs response somatic cell gene editing synergism tool working group

项目摘要

Overall PROJECT SUMMARY / ABSTRACT The University of California (UC) Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools will support studies in nonhuman primates that will advance the genome editing field, and significantly contribute to the future translation of these technologies for the treatment of human disease. The Nonhuman Primate Testing Center brings together a robust team of multidisciplinary investigators with campus partnerships that capitalize on major strengths at UC Davis including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The Nonhuman Primate Testing Center will offer state-of-the-art capabilities for Somatic Cell Genome Editing (SCGE) awardees to conduct high quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to providing research opportunities and collaborations to investigators nationwide. Through this powerful infrastructure the Nonhuman Primate Testing Center proposes the following Specific Aims: (1) Provide an administrative and organizational structure to advance somatic cell genome editing studies in nonhuman primates, (2) Foster partnerships with SCGE awardees through provision of resources that accelerate their research, and (3) Ensure synergism across the SCGE Program and Consortium via transparent interactions with the Dissemination and Coordinating Center, SCGE Working Group and Program Steering Committee, and the NIH. Our robust multidisciplinary team is poised to bring the depth and breadth of the UC Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools to support SCGE investigators nationwide and contribute substantially to the Common Fund SCGE Program.

全面的项目摘要 /摘要加利福尼亚大学（UC）戴维斯非人类灵长类动物测试中心，用于评估体细胞基因组编辑工具将支持非人类灵长类动物的研究，以推进基因组编辑领域，并显着促进这些技术治疗人类疾病的未来翻译。非人类灵长类动物测试中心将一个强大的跨学科研究人员团队与校园合作伙伴关系，利用加州大学戴维斯分校的主要优势，包括加利福尼亚国家灵长研究中心，基因组中心以及临床和转化科学中心。非人类的灵长类动物测试中心将为躯体细胞基因组编辑（SCGE）获奖者提供最先进的功能在非人类灵长类动物中进行高质量的研究。非人类灵长类动物测试中心利用A 支持框架，这表明了为提供研究机会的长期承诺以及全国调查人员的合作。通过这种强大的基础设施非人类灵长类动物测试中心提出了以下特定目的：（1）提供行政和组织结构为了推进非人类灵长类动物的体细胞基因组编辑研究，（2）与SCGE建立伙伴关系获奖者通过提供加速其研究的资源，以及（3）确保在 SCGE计划和财团通过与传播和协调中心的透明相互作用， SCGE工作组和计划指导委员会以及NIH。我们强大的多学科团队是准备带来UC Davis非人类灵长类动物测试中心的深度和广度进行评估体细胞基因组编辑工具，以支持全国SCGE调查人员，并为普通基金SCGE计划。