George M. O'Brien Kidney Center at Yale

耶鲁大学乔治·M·奥布莱恩肾脏中心

基本信息

批准号：
8584415
负责人：
PETER S. ARONSON
金额：
$ 124.88万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8584415
关键词：
Acute Renal Failure with Renal Papillary Necrosis Animal Model Animals Area Basic Science Biology Biomedical Research Blood Vessels Cell Line Cell physiology Cellular biology Chronic Kidney Failure Clinical Research Collaborations Country Education Epithelial Cells Fostering Functional disorder Funding Genetic Genomics Goals Grant Human Human Genetics Inflammation Inherited Injury Institution Instruction Investigation Kidney Kidney Diseases Medical Students Methods Molecular Mus Organism Phenotype Physiology Postdoctoral Fellow Prevention Renal function Renal glomerular disease Renal tubule structure Research Research Personnel Scientist Services Students Technology Training Training Activity Training Programs Translational Research United States National Institutes of Health Visit base bench to bedside experience graduate student kidney cell nephrogenesis new technology novel post-doctoral training programs symposium translational study undergraduate student

项目摘要

PROJECT SUMMARY (See instructions): This is an application for renewal of the George M. O'Brien Kidney Center at Yale. This center was established with the overarching goal to facilitate basic, translational and clinical research that will advance the prevention and treatment of kidney diseases. Major research areas of emphasis are renal epithelial cell biology and physiology; inherited kidney disease and kidney development; acute kidney injury (AKI) and chronic kidney disease (CKD); and vascular biology, inflammation and glomerular disease. A critically important benefit of the Center is to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, the Center includes three cores to provide small animal physiology and phenotyping services to enable detailed characterization of renal function at the level of the tubule, the kidney, and the intact organism in normal animals and in animal models of renal injury and kidney disease; provide mouse genetics and cell line services to develop novel animal models and kidney cell lines to elucidate the molecular mechanisms underlying normal renal function and the pathophysiology of kidney diseases; and provide human genetics and clinical research services to enhance the ability of renal investigators to apply advanced genetic and genomic technologies to human investigation. Our cores currently have a combined user base of approximately 90 investigators, including over 40 at outside institutions. A Pilot and Feasibility Program has the goals of providing initial project funding for young investigators, attracting new investigators into the field of kidney disease research, and fostering translational and clinical studies directly related to kidney diseases. In addition, an Enrichment Program enhances kidney disease research by maximizing interaction and information sharing among renal investigators and trainees, and by providing activities to enhance recruitment and education of all levels of trainees from undergraduate students to postdoctoral fellows.

项目摘要（参见说明）：这是耶鲁大学乔治 M.奥布莱恩肾脏中心更新的申请。该中心成立的总体目标是促进基础、转化和临床研究，以促进肾脏疾病的预防和治疗。主要研究领域为肾上皮细胞生物学和生理学；遗传性肾脏疾病和肾脏发育；急性肾损伤（AKI）和慢性肾病（CKD）；以及血管生物学、炎症和肾小球疾病。该中心的一个极其重要的好处是为耶鲁大学和全国各地的肾脏研究人员提供高度专业化的服务，而这些服务通常无法支持他们的研究。为此，该中心包括三个核心，提供小动物生理学和表型分析服务，以便在正常动物以及肾损伤和肾脏动物模型中，在肾小管、肾脏和完整有机体水平上详细表征肾功能疾病;提供小鼠遗传学和细胞系服务，开发新型动物模型和肾细胞系，以阐明正常肾功能和肾脏疾病病理生理学的分子机制；提供人类遗传学和临床研究服务，以提高肾脏研究人员将先进的遗传和基因组技术应用于人类研究的能力。我们的核心目前拥有约 90 名研究人员的综合用户群，其中包括 40 多名外部机构的研究人员。试点和可行性计划的目标是为年轻研究人员提供初始项目资金，吸引新研究人员进入肾脏疾病研究领域，并促进与肾脏疾病直接相关的转化和临床研究。此外，丰富项目通过最大限度地提高肾脏研究人员和学员之间的互动和信息共享，并提供活动来加强从本科生到博士后的各级学员的招募和教育，从而加强肾脏疾病研究。