BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 9898309
• 负责人: Shyam S Mohapatra
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898309
• 关键词: Academy; Age; American; Antiviral Agents; Asthma; Award; Basic Science; Biological; Biological Assay; Biology; Biotechnology; Birds; CCL20 gene; Cancer Patient; Cardiopulmonary; Clinical; Collaborations; Combined Modality Therapy; Development; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Elderly; Endowment; Engineering; Extramural Activities; FDA approved; Florida; Formulation; Four-dimensional; Funding; Future; Genomic approach; Genomics; Goals; Grant Review; Health; Hospitalization; Hospitals; Hypersensitivity; Illness impact; Immunology; Individual; Inflammation; Inflammatory; Injury; Institutes; International; Iraq; Journals; Knowledge; Lead; Leadership; Legal patent; Literature; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of lung; Medical; Medicine; Mesenchymal Stem Cells; Methods; MicroRNAs; Military Personnel; Modeling; Nanotechnology; Nature; Nerve Regeneration; Nursing Faculty; Peptides; Pharmaceutical Preparations; Phospholipids; Pneumonia; Publications; Rattus; Reporting; Research; Research Activity; Research Personnel; Research Support; Respiratory Syncytial Virus Infections; Respiratory syncytial virus; Scientist; Seminal; Small Interfering RNA; System; TBI treatment; Technology; Testing; Therapeutic; Training; Translational Research; Translations; Traumatic Brain Injury; United States National Institutes of Health; Universities; Veterans; Viral; Viral Respiratory Tract Infection; Virus Diseases; Work; age group; base; bench to bedside; cancer diagnosis; cancer therapy; career; clinical diagnostics; clinical investigation; combinatorial; drug efficacy; efficacy testing; evidence base; experience; graduate student; high risk; human disease; inhibitor/antagonist; innovation; nano; nanofiber; nanomedicine; nanoscale; neoplasm registry; novel; novel diagnostics; novel therapeutics; personalized cancer therapy; prevent; professor; programs; prophylactic; scaffold; stem cell therapy; translational medicine

This proposal seeks to renew Research Career Scientist Award held by Dr. Shyam S Mohapatra at the James A. Haley VA Hospital in Tampa, Florida since 2007. He is a Distinguished Health Professor and the Director of the Division of Translational Medicine- Center for Research and Education in Nanobioengineering at the VA-affiliated academic center- the University of South Florida. He is recognized nationally and internationally for his contribution to the field of nanoscale biomedical diagnostics and therapeutics in relation to a number inflammatory diseases including asthma, viral infections, traumatic brain injury (TBI) and cancers. He has received substantial extramural research support including awards from the NIH, DOA, ONR, Department of Veterans’ Affairs and Florida Department of Health. In addition to the two international awards early in his academic career, he is the recipient of the USF biotechnology award, the Sigma XI award, TBTF Technology Leadership Award, Excellence in Research and Innovation award and Global Corporate award in Nanotechnology. He has contributed substantially to scientific literature including over 170 publications, some in very high impact journals such as Nature Medicine and journal of Clinical Investigation, and has >30 U.S. and foreign patents. He is a Fellow of the National Academy of Inventors and of the American Institute of Medical and Biological Engineering. In recognition of his contribution to the biomedical nanotechnology, he was inducted to the “Florida Inventors’ Hall of Fame” in 2014. In addition, he has devoted his efforts in training clinical fellows and graduate students in research and teaching at the VA hospital. Dr. Mohapatra has been a research investigator at the VA Hospital since 1996 and has been funded with the Merit Review Award focused on respiratory syncytial virus (RSV) infection since 1999. His lab has contributed substantially to the translation of new genomic approaches such as those involving small-interfering RNAs (siRNA) and microRNAS and emerging field of nanomedicine, with the premise that these technologies will aid in developing new methods for diagnosis and therapy of diseases afflicting Veterans. Current research activities to be supported by this RCS Award are as follows. Project #1. Develop new prophylactic and/or therapeutic approaches using novel nanoscale technologies, which are effective against both primary and secondary RSV infections, broadly useful in all age groups and inexpensive. His proposed merit review project (A1 revision to be submitted) aims to develop a simple, smart and scalable nanomicellar system that combines novel targets for viral fusion-, cellular antiviral- and replication-inhibitors. Project #2. Investigate the potential of a novel combinatorial therapeutic approach in a rat model of moderate TBI that includes (i) a treatment to reduce inflammation (local and systemic) using a nano-formulated siRNA against a recently discovered target, CCL20, and (ii) a second treatment to promote neuroregeneration by mesenchymal stem cell therapy. Project #3. Develop a novel cellomic-based personalized cancer treatment approach using a four-dimensional (4D) tumoroid culture platform. The assay can be used by itself or as an adjunct assay to currently practiced genomic testing, which predicts drug(s) that will be the most appropriate for the treatment of that patient’s cancer. These innovative applications of nanomedicine approaches taken together are expected to lead to high impact therapies for Veterans and other Americans in need. !

该建议旨在续签Shyam S Mohapatra博士在 自2007年以来 教授兼转化医学研究中心主任 - VA隶属学术中心的纳米比工程教育 - 南部大学 佛罗里达。他因对纳米级领域的贡献而在国内和国际上得到认可 与多种炎症性疾病有关的生物医学诊断和治疗 哮喘，病毒感染，创伤性脑损伤（TBI）和癌症。他已经获得了大量 外壁外研究支持，包括NIH，DOA，ONR，退伍军人部的奖项 事务和佛罗里达卫生部。除了两个国际奖项之外 学术生涯，他是USF生物技术奖，Sigma XI奖，TBTF的获得者 技术领导奖，研究与创新卓越奖和全球 纳米技术公司奖。他为科学文学做出了重大贡献 包括超过170个出版物，有些在很高的影响期刊上，例如自然医学和 临床调查杂志，拥有30项美国和外国专利。他是 美国国家发明家学院和美国医学与生物学研究所 工程。认识到他对生物医学纳米技术的贡献，他被归纳 对于2014年的“佛罗里达州发明家名人堂”。此外，他还致力于培训 弗吉尼亚州医院研究和教学的临床研究员和研究生。 Mohapatra博士自1996年以来一直是VA医院的研究调查员 由重点是呼吸综合病毒（RSV）感染的优异审查奖资助 自1999年以来。他的实验室为新基因组方法的翻译做出了重大贡献 例如涉及涉及小型RNA（siRNA）和microRNA和新兴领域的那些 纳米医学的前提是，这些技术将有助于开发新方法 困扰退伍军人的疾病的诊断和治疗。当前支持的研究活动 通过此RCS奖，如下。 项目＃1。使用新型纳米级开发新的预防性和/或治疗方法 广泛针对原发性和继发性RSV感染有效的技术 在所有年龄段和便宜的年龄段中都有用。他提出的优异审查项目（A1修订为 提交的）旨在开发一种简单，智能和可扩展的纳米粒子系统，该系统结合了小说 病毒融合，细胞抗病毒和复制抑制剂的靶标。 项目＃2。研究大鼠新型组合治疗方法的潜力 中等TBI模型，包括（i）使用（局部和全身）使用的治疗方法 针对最近发现的靶标CCL20和（ii）第二次处理的纳米形成的siRNA 通过间充质干细胞疗法促进神经创造。 项目＃3。使用一种新型的基于大细胞的个性化癌症治疗方法 一个四维（4D）瘤培养平台。该测定可以自身或辅助 对当前实践基因组测试的测定，该测试预测药物将是最大的 适合治疗该患者的癌症。 预计纳米医学方法的这些创新应用将是 为退伍军人和其他有需要的美国人带来高影响力疗法。