Biological Mechanisms of Suicidal Behavior among Sexual Minority Adolescents

性少数青少年自杀行为的生物学机制

基本信息

批准号：
9898464
负责人：
Brian Thoma
金额：
$ 16.83万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9898464
关键词：
Adolescence Adolescent Adult Age Attenuated Behavioral Biological Biological Markers Bisexual C-reactive protein Cause of Death Child Abuse Childhood Chronic Clinical Collaborations Data Decision Making Development Environment Ethnic Origin Exhibits Feeling suicidal Frequencies Gambling Gays Hair Hydrocortisone Impairment Impulsivity Individual Inflammation Inflammatory Intervention Interview Investigation Iowa Knowledge Lesbian Literature Longitudinal Studies Marshal Mental Health Mentors Mentorship Modeling Neurocognitive Pathway interactions Patient Self-Report Performance Phase Population Positioning Attribute Psychoneuroimmunology Psychopathology Psychosocial Factor Questionnaires Race Reporting Research Research Design Research Domain Criteria Research Methodology Research Personnel Research Training Risk Same-sex Sex Behavior Sex Orientation Sexual abuse Shame Stigmatization Suicide Suicide attempt Time Training Visit Vulnerable Populations adolescent health biological sex bullying clinical predictors clinically significant demographics experience health disparity hypothalamic-pituitary-adrenal axis ideation improved inflammatory marker longitudinal analysis peer physical abuse programs psychosocial recruit reducing suicide sex sexual minority social stressor suicidal adolescent suicidal behavior suicidal risk suicide attempter therapy design young adult

项目摘要

Project Summary/Abstract Suicide is the second leading cause of death among adolescents, and nationally representative data indicate 29% of sexual minority adolescents (SMAs) have attempted suicide during the past year. Alarmingly high rates of suicidal behavior in this population can be attributed, in part, to gay-related bullying experienced by SMAs and higher rates of childhood abuse among SMAs. However, mechanisms underlying the association between psychosocial factors and suicidality among SMAs remain unstudied. The proposed investigation will examine biological mechanisms of suicidal behavior among SMAs. Researchers have recently identified biological mechanisms which distinguish individuals who are at risk for engaging in suicidal behavior, including low hair cortisol concentrations (HCC) and high levels of inflammatory biological markers. Biological mechanisms have high potential to partially explain suicidal behavior disparities between SMAs and non-SMAs, as individuals who experience bullying and childhood abuse are more likely to evidence biological dysregulation during adolescence and into adulthood. The proposed K01 study will examine how biological mechanisms (HCC and inflammatory markers) are associated with gay-related bullying, and how biological mechanisms predict clinical and neurocognitive correlates of suicidal behavior (suicidal ideation, impulsivity, and decision-making) among SMAs and non-SMAs. The proposed study will be the first in a program of research designed to facilitate more effective identification of SMAs at risk for suicidal behavior and identify psychosocial, biological, and neurocognitive factors which can be targeted within interventions designed to attenuate stark disparities in suicidal behavior between SMAs and non-SMAs. To launch this program of research, the candidate will augment his prior training in social and behavioral determinants of SMA health with training in biological mechanisms of suicidal behavior, conducting longitudinal research and analyzing longitudinal data, and neurocognitive correlates of suicidal behavior. He has an ideal mentorship team within an optimal scientific training environment to undertake the proposed research and training plans. Primary Mentor Dr. Nadine Melhem has significant expertise in biological mechanisms of suicidal behavior and longitudinal research methods. Co-Mentor Dr. Michael Marshal is an expert on SMA mental health disparities, including suicidality. The candidate will also receive mentoring from internal Consultant Dr. Anna Marsland, a leading scholar in psychoneuroimmunology, internal Consultant Dr. Kehui Chen, a statistician with ongoing collaborations with Dr. Melhem, and external Consultant Dr. Jeffrey Bridge, who contributes expertise in neurocognitive risk for suicidal behavior among adolescents. Completion of the proposed research and training plans will position the candidate as a leading scholar in SMA suicidal behavior, preparing him to examine this pressing mental health disparity longitudinally across adolescence and at multiple levels of analysis.

项目概要/摘要自杀是青少年第二大死亡原因，并且具有全国代表性的数据表明 29% 的性少数青少年 (SMA) 在过去一年中曾试图自杀。令人震惊的是该人群自杀行为的高发生率可部分归因于与同性恋相关的欺凌经历 SMA 的儿童受虐待率较高。然而，该协会背后的机制 SMA 中心理社会因素与自杀之间的关系尚未得到研究。拟议的调查将研究 SMA 自杀行为的生物学机制。研究人员最近发现了区分有风险的个体的生物机制有自杀行为，包括头发皮质醇浓度低 (HCC) 和炎症水平高生物标记。生物学机制很有可能部分解释自杀行为的差异 SMA 和非 SMA 之间的差异，因为经历过欺凌和童年虐待的人更有可能青春期和成年期间生物失调的证据。拟议的 K01 研究将检查生物学机制（HCC 和炎症标志物）如何与同性恋相关欺凌，以及生物机制如何预测自杀行为的临床和神经认知相关性 SMA 和非 SMA 之间的（自杀意念、冲动和决策）。拟议的研究将是旨在促进更有效地识别有自杀风险的 SMA 的研究计划中的第一个行为并确定可以针对的心理社会、生物和神经认知因素旨在缩小 SMA 和非 SMA 之间自杀行为明显差异的干预措施。为了启动这个研究计划，候选人将加强他之前在社会和 SMA 健康的行为决定因素，并接受自杀行为生物学机制的培训，进行纵向研究和分析纵向数据以及自杀行为的神经认知相关性。他在最佳的科学培训环境中拥有理想的导师团队来承担拟议的任务研究和培训计划。首席导师 Nadine Melhem 博士在生物领域拥有丰富的专业知识自杀行为的机制和纵向研究方法。共同导师迈克尔·马歇尔博士是 SMA 心理健康差异（包括自杀倾向）专家。候选人还将获得来自以下机构的指导：内部顾问 Anna Marsland 博士，心理神经免疫学领先学者，内部顾问 Dr. Anna Marsland Kehui Chen，统计学家，与 Melhem 博士和外部顾问 Jeffrey 博士持续合作 Bridge 提供了青少年自杀行为的神经认知风险方面的专业知识。完成拟议的研究和培训计划将使候选人成为 SMA 自杀领域的领先学者行为，让他准备好纵向审视青春期和青少年时期这种紧迫的心理健康差异在多个层面进行分析。