Development and implementation of a comparison occupational cohort for the WTC GRC

为 WTC GRC 开发和实施比较职业群体

• 批准号: 9769592
• 负责人: SUSAN L TEITELBAUM
• 金额: $ 50万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769592
• 关键词: Development; implementation; comparison; occupational; cohort

Project Summary World Trade Center (WTC) first responders have suffered numerous diseases and conditions as a result of their efforts on 9/11 and afterwards. For example, it has been noted that there are numerous cases of aerodigestive disorders amongst the responders, including sinusitis, asthma, interstitial lung disease, and gastroesophageal reflux. Similarly, there are reports of higher than expected rates of certain cancers, such as multiple myeloma, prostate, and thyroid. Also reported are relatively high rates of post-traumatic stress disorder, anxiety, depression, and sleep apnea. The commonality in these reports is the comparator groups against which the data from the WTC General Responders Cohort (WTC-GRC) were measured. The comparator groups were either national or local (e.g., the NY State Cancer Registry) and were composed of members of the general population, not occupational groups. The purpose of this proposal is the development of a unique occupational cohort, based in part on patients attending the Mount Sinai Selikoff Centers for Occupational Health (SCOH), as well as workers presenting to other departments within Mount Sinai, and workers recruited through outreach efforts. The reasoning is that for valid estimates of the health of the first responders, comparisons must be against a working population and not the general population, which can lead to intractable bias and faulty assessments. The specific aims of the proposed project include: 1) converting existing SCOH data into a usable database for comparative analyses of WTC-related health conditions; 2) building a new occupational cohort to serve as a comparison in the longitudinal assessment of health in the WTC-GRC; and 3) utilizing the newly created comparison cohort to determine if gastroesophageal reflux disease (GERD) incidence in the WTC-GRC differs from an unexposed worker population. The results of the proposed project will improve the quality of the health related studies being done by providing a more appropriate comparison group that can be matched to responders on several important characteristics, including occupation, age, sex and race/ethnicity. Such studies will result in improved estimates of disease risk and add important knowledge to what we currently understand about exposure to 9/11 toxins and stressors.

项目摘要 世界贸易中心（WTC）的第一响应者由于 他们在9/11和之后的努力。例如，已经注意到有很多案例 响应者中的机械化疾病，包括鼻窦炎，哮喘，间质性肺病和 胃食管反流。同样，有报道称某些癌症的预期率高，例如 多发性骨髓瘤，前列腺和甲状腺。还报道的是创伤后应激率相对较高 障碍，焦虑，抑郁和睡眠呼吸暂停。这些报告中的共同点是比较组 测量了WTC总响应者队列（WTC-GRC）的数据。这 比较组是国家或地方（例如，纽约州癌症登记册），由 普通人群的成员，而不是职业群体。该提议的目的是发展 独特的职业队列，部分基于参加西奈山Selikoff中心的患者 职业健康（SCOH），以及向西奈山境内其他部门介绍的工人， 工人通过外展工作招募。原因是为了有效估计第一个的健康 响应者，比较必须与劳动人口而不是一般人群相对，这可以领导 棘手的偏见和评估错误。 拟议项目的具体目的包括：1）将现有SCOH数据转换为可用数据库 与WTC相关的健康状况的比较分析； 2）建立一个新的职业队列作为 WTC-GRC健康纵向评估的比较； 3）利用新创建的 比较队列以确定WTC-GRC中胃食管反流疾病（GERD）的发生率是否有所不同 来自未暴露的工人人口。 拟议项目的结果将提高由健康相关研究的质量 提供一个更合适的比较组，可以与几个重要的响应者匹配 特征，包括职业，年龄，性别和种族/种族。这样的研究将改善 估计疾病风险，并为我们目前了解暴露的知识添加重要知识 9/11毒素和压力源。