3D Printed Nano-Bionic Organs

3D打印纳米仿生器官

• 批准号: 8742786
• 负责人: Michael McAlpine
• 金额: $ 2.04万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742786
• 关键词: 3D Print; Acoustics; Address; Anatomy; Area; Auditory; Biological; Biology; Bionics; Cartilage; Cells; Cochlea; Development; Devices; Ear; Electrodes; Electronics; Exhibits; Eye; Frequencies; Generations; Geometry; Human; Hydrogels; Impairment; In Vitro; Investigation; Left; Methods; Music; Nose; Organ; Polymers; Printing; Process; Prosthesis; Radio; Regenerative Medicine; Shapes; Silver; System; Tissue Engineering; Tissues; Ultrasonics; User-Computer Interface; Work; biological systems; nano; nanomaterials; nanoparticle; novel; novel strategies; prevent; public health relevance; two-dimensional

DESCRIPTION (provided by applicant): The development of approaches for multidimensional integration of functional electronic components with biological tissue and organs could have tremendous impact in regenerative medicine, smart prosthetics, and human-machine interfaces. However, current electronic devices and systems are inherently two dimensional and rigid, thus prohibiting seamless meshing with three-dimensional, soft biology. The ability to three-dimensionally interweave biological tissue with functional electronics could enable the creation of bionic organs for restoring impairments, or enhancing human functionalities over their natural limitations. Current electronics are inherently two-dimensional, preventing seamless integration with biology, as the processes and materials used to create synthetic tissue constructs vs. conventional electronic devices are very different. Here, we present a novel strategy for overcoming these difficulties via additive manufacturing of biological cells with various classes of functional electronic nanomaterials. Recently, we have generated a functional bionic ear via 3D printing of a cell-seeded hydrogel matrix in the precise anatomic geometry of a human ear, along with an intertwined conducting polymer consisting of infused silver nanoparticles. This allowed for the in vitro culturing of cartilage tissue around an inductive coil antenna in the ear, which subsequently connects to cochlea-shaped electrodes. The printed ear exhibits enhanced auditory sensing for radio frequency reception, and complementary left and right ears can listen to stereo music. Here, we propose extending this approach to new functionalities - such as ultrasonic acoustic reception and vasculature - and bionic organs, including bionic eyes and a bionic nose. Overall, our approach presents a disruptive and paradigm-shifting new method to intricately merge biology and electronics via 3D printing. The work outlined here thus constitutes a novel, highly interdisciplinary investigation to addressing outstanding questions in the generation of bionic organs, and we anticipate that this work will represent a paradigm-shift in both tissue engineering, as well as 3D interweaving of functional electronics into biological systems.

描述（由申请人提供）：功能电子元件与生物组织和器官多维集成的方法的开发可能会对再生医学、智能假肢和人机界面产生巨大影响。然而，当前的电子设备和系统本质上是二维的和刚性的，因此无法与三维的软生物学无缝啮合。将生物组织与功能电子器件进行三维交织的能力可以创建仿生器官来恢复损伤，或增强人类功能以超越其自然限制。当前的电子产品本质上是二维的，无法与生物学无缝集成，因为用于创建合成组织结构的工艺和材料与传统电子设备非常不同。在这里，我们提出了一种新策略，通过使用各类功能电子纳米材料增材制造生物细胞来克服这些困难。最近，我们通过 3D 打印在人耳精确的解剖几何结构中植入细胞的水凝胶基质，以及由注入的银纳米粒子组成的交织导电聚合物，生成了功能性仿生耳。这使得可以在耳朵中的感应线圈天线周围进行软骨组织的体外培养， 随后连接到耳蜗形电极。印刷耳朵表现出增强的射频接收听觉感应，互补的左耳和右耳可以聆听立体声音乐。在这里，我们建议将这种方法扩展到新的功能——例如超声波接收和脉管系统——以及仿生器官，包括仿生眼睛和仿生鼻子。总的来说，我们的方法提出了一种颠覆性的、范式转变的新方法，通过 3D 打印将生物学和电子学错综复杂地融合在一起。因此，这里概述的工作构成了一项新颖的、高度跨学科的研究，旨在解决仿生器官生成中的突出问题，我们预计这项工作将代表组织工程以及功能电子学与生物器官的 3D 交织的范式转变。系统。