A tailored, health communication intervention for HPV vaccine hesitant families

为 HPV 疫苗犹豫家庭量身定制的健康沟通干预措施

基本信息

批准号：
9892286
负责人：
Jennifer C. Erves
金额：
$ 13.49万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9892286
关键词：
Address Adolescent Advisory Committees African American Age Anus Anxiety Applications Grants Attitude Award Behavior Behavior Therapy Behavioral Car Phone Cervical Childhood Clinic Clinic Visits Clinical Clinical Research Clinical Trials Communities Complement Computer software Conduct Clinical Trials Custom Data Disease Dose Education Educational Intervention Environment Family Feedback Funding Future Goals Health Communication Health Personnel Health education Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Incidence Individual Interdisciplinary Study Intervention Intervention Studies Interview Knowledge Leadership Malignant Neoplasms Malignant Vaginal Neoplasm Malignant neoplasm of anus Malignant neoplasm of cervix uteri Malignant neoplasm of penis Malignant neoplasm of vulva Manuscripts Measures Medical Mentored Research Scientist Development Award Mentors Misinformation Modeling Modification Morbidity - disease rate Motivation Oncology Oropharyngeal Outcomes Research Parents Patient Education Patient-Focused Outcomes Patients Pediatrics Perception Physicians Pilot Projects Play Population Postdoctoral Fellow Prevention Research Process Protocols documentation Provider Public Health Publications Randomized Randomized Clinical Trials Recommendation Research Research Methodology Research Personnel Resources Role Safety Schedule Secure Sex Behavior Site Source Statistical Data Interpretation Structure Surveys Tennessee Testing Training Training Activity Treatment Efficacy Trust Underserved Population Uninsured Universities Vaccines Vagina Visit Vulva Work base cancer prevention career career development clinical care clinical encounter clinically significant control trial disparity reduction evidence base experience health belief implementation science improved innovation medical schools mortality motivational enhancement therapy patient-clinician communication penis preference prevent professor programs public health priorities public health relevance public health research recruit retention rate safety net satisfaction shared decision making side effect social norm theories therapy development transmission process treatment as usual trial design uptake

项目摘要

Abstract The human papillomavirus (HPV) causes 90% of cervical cancers and is implicated in multiple other cancers. The HPV vaccine can prevent the vast majority of these cancers, but it is underused in adolescents, especially among those within vaccine hesitant (VH) parents. Dr. Erves, an Assistant Professor in Research at Meharry Medical College and Adjunct Assistant Professor at Vanderbilt University, is poised to become a leader in behavioral cancer prevention research. This Mentored Research Scientist Development Award (K01) will complement her in-depth training in public health research methods, statistical analysis, patient centered outcomes research, and community engagement obtained during her doctoral, post-doctoral, and early career experiences. It will provide the training she needs to further her current cancer prevention research program, characterizing preferences and perceived needs of African American adolescents and parents when deciding about HPV vaccination for cancer prevention. Dr. Erves short-term goals are to become proficient in behavioral intervention development, an expert in conducting clinical trials, and knowledgeable of implementation science by engaging in didactic, clinical research training activities; conducting a pilot, randomized clinical trial; submitting an R01 in Year 3 of this award; increasing manuscript publications; and advancing leadership through scientific presentations. Her mentors include highly-qualified experts in community engagement and clinical trials (Dr. Consuelo Wilkins), HPV vaccination and behavioral interventions (Dr. Pamela Hull), and vaccine hesitancy, clinical interventions, and implementation science (Dr. Amanda Dempsey). State-of-the-art facilities and vast resources at Meharry Medical College and Vanderbilt University provide the environment needed to promote her career development, and complete the proposed research successfully. The proposed research is to develop and pilot test a tailored, health communication intervention aimed to increase HPV vaccination among VH parents. The research will add knowledge on how tailored education provided before a doctor’s visit can play a role in improving HPV vaccination rates among underserved, VH parents. The study aims to develop a tailored, health communication intervention for HPV VH parents (AIM 1); conduct a pilot study of the intervention and study protocol on a small scale to demonstrate feasibility of a future full-scale randomized control trial (RCT) (AIM 2); and examine acceptability of the protocol and intervention among parents and providers (AIM 3). The proposed research is innovative because no evidence-based health communication interventions target HPV VH parents, and we will use stakeholder engagement throughout this study. The knowledge, experience, and pilot data provided by this award will prepare Dr. Erves to secure subsequent R01 funding to assess the intervention’s efficacy in a well-powered RCT and advance her multidisciplinary, research program on behavioral interventions to increase HPV vaccine rates. This award will allow her to establish an independent, long-term career focused more broadly on cancer prevention behaviors.

抽象的人乳头瘤病毒（HPV）导致90％的宫颈癌，并在其他多种癌症中实施。 HPV疫苗可以预防这些癌症的绝大多数，但在青少年中没有用，尤其是在疫苗犹豫不决（VH）的父母中。梅哈里（Meharry）研究助理教授Erves博士范德比尔特大学的医学院和兼职助理教授被毒死成为领导者行为癌症预防研究。这个指导的研究科学家发展奖（K01）将补充她在公共卫生研究方法中的深入培训，统计分析，患者中心成果研究以及在博士，博士后和早期职业期间获得的社区参与经验。它将提供她为进一步预防癌症预防研究计划所需的培训，在决定时表征非裔美国青少年和父母的偏好和感知需求关于预防癌症的HPV疫苗接种。 Erves博士的短期目标是精通行为干预开发，进行临床试验的专家，并知识渊博通过进行教学，临床研究培训活动；进行试点，随机临床试验；在本奖项的第3年中提交R01；增加手稿出版物；并提高领导力通过科学演示。她的导师包括社区参与方面合格的专家临床试验（Consuelo Wilkins博士），HPV疫苗接种和行为干预措施（Pamela Hull博士）和疫苗犹豫，临床干预和实施科学（Amanda Dempsey博士）。最先进的梅哈里医学院和范德比尔特大学的设施和大量资源为环境提供了需要促进她的职业发展，并完全成功地进行拟议的研究。提议研究是为了开发和试点测试，旨在增加HPV的量身定制的健康交流干预措施 VH父母的疫苗接种。该研究将增加有关如何在医生的访问可以在提高服务不足的VH父母中提高HPV疫苗接种率中发挥作用。研究旨在为HPV VH父母开发量身定制的健康交流干预措施（AIM 1）；进行飞行员研究干预措施和研究方案小规模的研究，以证明未来全尺度的可行性随机对照试验（RCT）（AIM 2）；并检查协议的可接受性和干预措施父母和提供者（目标3）。拟议的研究具有创新性，因为没有循证健康沟通干预措施针对HPV VH父母，我们将在此过程中使用利益相关者的参与学习。该奖项提供的知识，经验和试验数据将使Erves博士为保护随后的R01资金，以评估干预效率的RCT效率并提高她多学科的行为干预研究计划，以提高HPV疫苗率。这个奖项将让她建立独立的长期职业，更广泛地关注预防癌症的行为。