Resource-based Center for the Advancement of Precision Medicine in Rheumatology

风湿病精准医学推进资源中心

基本信息

批准号：
9768155
负责人：
Lindsey Ann Criswell
金额：
$ 72.64万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768155
关键词：
ARHGEF5 gene Address Age Ankylosing spondylitis Arthritis Autoimmunity Behavioral Big Data Bioinformatics Biomedical Research California Childhood Clinic Clinical Clinical Data Clinical Informatics Clinical Research Collaborations Communities Computational Biology Consultations Data Data Analyses Data Collection Databases Development Diagnosis Disease Electronic Health Record Environment Etiology Fostering Funding Genetic Genomics Goals Grant Health Heterogeneity Immunology Laboratory Research Leadership Longevity Lupus Mentors Molecular Molecular Biology Monitor National Institute of Allergy and Infectious Disease National Institute of Arthritis and Musculoskeletal and Skin Diseases National Research Council Outcome Patient Recruitments Patients Physicians Play Populations at Risk Prevention Reporting Research Research Design Research Ethics Research Infrastructure Research Personnel Resources Rheumatism Rheumatoid Arthritis Rheumatology Role San Francisco Scientist Scleroderma Secure Selection for Treatments Series Services Technology Training United States National Institutes of Health Universities Vasculitis Vision accurate diagnosis base clinical care clinical phenotype data integration data management data warehouse design disease diagnosis disorder subtype ethnic minority population experience genomic data human data human subject improved innovation medical specialties molecular phenotype multidisciplinary new technology novel strategies novel therapeutics outcome forecast pediatric rheumatic diseases phenotypic data precision medicine programs racial and ethnic ranpirnase recruit research study symposium tool treatment response

项目摘要

PROJECT SUMMARY/ABSTRACT The UCSF Resource-based Center for the Advancement of Precision Medicine in Rheumatology (P30) will provide critically important resources and expertise to enable cutting-edge rheumatic disease research. Given the emerging opportunities related to precision medicine, in conjunction with the significant heterogeneity encompassed within the rheumatic diseases, our Center will focus on providing resources for research that seeks to define underlying etiologic heterogeneity within and across rheumatic diseases by applying new approaches and technology developed as part of the exciting field of precision medicine. UCSF represents an ideal environment for the proposed P30 Center given tremendous institutional strengths in immunology, genomics, molecular technologies, computational biology, and clinical research, including engagement of at-risk populations and racial/ethnic minorities. In addition, UCSF is recognized as a leader in clinical care of rheumatic disease patients across the age span, from childhood to old age. Further supporting the rationale for investing in our Center are the substantial resources that can be leveraged at UCSF: sub- specialty rheumatic disease clinics for lupus, rheumatoid arthritis, vasculitis, scleroderma, ankylosing spondylitis, and pediatric rheumatic disease; the NIH-funded UCSF Multidisciplinary Clinical Research Center (NIAMS P60) and Autoimmunity Center of Excellence (NIAID ACE); and the UCSF-Stanford Arthritis Center of Excellence. To facilitate innovative and collaborative rheumatic disease research, our Center will include: 1) a Human Subjects and Clinical Phenotyping Core co-directed by Drs. Patricia Katz and Jinoos Yazdany, which will provide centralized coordination of subject recruitment, clinical phenotyping, and clinical data collection and management (e.g., for electronic health record data, and patient or physician reported outcomes); 2) a Genomics and Molecular Resources Core, co-directed by Drs. Pui-Yan Kwok and Lindsey Criswell, which will provide centralized biospecimen processing and storage to facilitate access for more researchers and provide consultation and coordination related to acquisition of genomics and molecular phenotyping services; 3) an Integrative Bioinformatics Core, co-directed by Drs. Atul Butte and Marina Sirota, which will provide computational and analytical expertise for study design, bioinformatics analysis of clinical and molecular data, data integration and data dissemination; and 4) an Administrative Core directed by Dr. Lindsey Criswell, with Dr. Mary Nakamura as associate director, which includes an enrichment program designed to attract and support both young and experienced investigators through provision of pilot grants, a mentoring program, educational seminars, and an annual symposium. These resources will meet the stated needs of our research community and will have a major impact on advancing precision medicine research in rheumatology by providing access to research infrastructure and consultation, biospecimens with defined clinical data, and cutting-edge genomics, molecular, and computational biology tools.

项目概要/摘要加州大学旧金山分校风湿病精准医学推进资源中心 (P30) 将为尖端风湿病研究提供至关重要的资源和专业知识。鉴于与精准医疗相关的新兴机遇，结合重大由于风湿病的异质性，我们中心将重点为以下领域提供资源：旨在通过以下方式定义风湿性疾病内部和之间潜在病因异质性的研究：应用作为令人兴奋的精准医学领域一部分而开发的新方法和技术。加州大学旧金山分校鉴于在以下方面的巨大机构优势，为拟议的 P30 中心提供了理想的环境免疫学、基因组学、分子技术、计算生物学和临床研究，包括高危人群和少数种族/族裔的参与。此外，加州大学旧金山分校 (UCSF) 被公认为以下领域的领导者：风湿病患者的临床护理跨越年龄跨度，从童年到老年。进一步支持投资我们中心的理由是 UCSF 可以利用大量资源：狼疮、类风湿性关节炎、血管炎、硬皮病、强直性关节炎的风湿病专科诊所脊柱炎和小儿风湿病； NIH 资助的 UCSF 多学科临床研究中心 (NIAMS P60) 和自身免疫卓越中心 (NIAID ACE)；和加州大学旧金山分校-斯坦福关节炎中心卓越。为了促进风湿病的创新和协作研究，我们的中心将包括：1) 人类受试者和临床表型核心由博士共同指导。帕特里夏·卡茨和吉诺斯·亚兹达尼，这将提供受试者招募、临床表型分析和临床数据的集中协调收集和管理（例如，电子健康记录数据以及患者或医生报告的数据）结果）； 2) 基因组学和分子资源核心，由博士共同指导。郭培恩和 Lindsey Criswell，将提供集中的生物样本处理和存储，以方便获取更多样本研究人员并提供与基因组学和分子学获取相关的咨询和协调表型分析服务； 3）综合生物信息学核心，由 Drs 共同指导。阿图尔巴特和码头 Sirota，将为研究设计、生物信息学分析提供计算和分析专业知识临床和分子数据、数据整合和数据传播； 4) 一个行政核心指导由 Lindsey Criswell 博士担任，Mary Nakamura 博士担任副主任，其中包括一项强化计划旨在通过提供试点资助来吸引和支持年轻和经验丰富的研究人员，指导计划、教育研讨会和年度研讨会。这些资源将满足规定的我们研究界的需求，将对推进精准医学研究产生重大影响风湿病学通过提供研究基础设施和咨询、具有明确定义的生物样本临床数据以及尖端的基因组学、分子和计算生物学工具。