Critical Translational Studies in Pediatric Nephrology

小儿肾病学的批判性转化研究

• 批准号: 9766259
• 负责人: PRASAD DEVARAJAN
• 金额: $ 84.55万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766259
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Area; Biological Markers; Biomedical Research; Childhood; Clinical; Direct Costs; Disease; Financial Hardship; Fostering; Funding; Future; Gene Expression; Goals; Grant; Instruction; International; Kidney Diseases; Leadership; Legal patent; Lupus Nephritis; Manuscripts; Medicine; Mentors; Mission; Nephrology; Outcome; Peer Review; Pilot Projects; Principal Investigator; Proteomics; Public Health; Research; Research Personnel; Research Project Grants; Resources; Science; Training; base; bench to bedside; biomedical resource; career development; innovation; interdisciplinary approach; kidney fibrosis; multidisciplinary; novel; off-patent; programs; response; translational study

Program Director/Principal Investigator (Last, First, Middle): Devarajan, Prasad PROJECT SUMMARY (See instructions): In response to RFA-DK-16-032, our overall goal is to renew the highly successful CCHMC PCEN, which in the past 4 years has yielded 88 peer-reviewed manuscripts, 15 new grants funded, and 8 new patent applications with 4 final patents issued. The overarching theme of the CCHMC PCEN is to conduct innovative and high-impact bench-to-bedside studies on three critical but underserved pediatric kidney diseases. For the renewal, we are retaining acute kidney injury and lupus nephritis as focus areas from the current PCEN, and adding a new focus area of kidney fibrosis. The specific aims include: (1) to attract outstanding expertise into the study of critical but underserved pediatric kidney diseases, (2) to foster multidisciplinary approaches to the study of critical but underserved pediatric kidney diseases, (3) to provide high-resource Biomedical Research Cores to support the study of critical but underserved pediatric kidney diseases, and (4) to support novel exploratory pilot studies that will form the basis for future investigator- initiated applications. Three Primary Research Projects are proposed in each of the three focus areas, from recognized teams of interdisciplinary investigators with a portfolio of about 100 federal grants. Also included are high-resource Gene Expression, Proteomics, Biomarker, and Administrative Cores with PIs of international repute to support the study of the three focus areas. Evidence for the critical need for the proposed Cores to complete the objectives of the proposed Primary and Pilot research grants is provided. The four proposed Pilot and Feasibility Projects represent multidisciplinary studies from highly promising young investigators who have been strategically paired with senior investigators to mentor their career development via independent investigator-initiated applications. Evidence for strong support from institutional leadership, institutional CTSA, and the Nephrology T32 Training Grant is provided. The PCEN includes a Research Base of 15 investigators, and an overall direct cost request of $750,000 annually. Other strengths include the CCHMC Pediatric Nephrology Division, with tremendous breadth and depth of clinical volume, resources, and research funding, and with a proven track record ofcollaborations in the three focus areas. the application. Do not use suffixes such as 4a, 4b.

项目总监/首席研究员（最后，第一，中间）：Prasad Devarajan 项目摘要（请参阅说明）： 为了响应RFA-DK-16-032，我们的总体目标是续订非常成功的CCHMC PCEN，它在 在过去的4年中，产生了88个同行评审的手稿，15个新赠款和8项新专利 具有4项最终专利的申请。 CCHMC PCEN的总体主题是进行 关于三个关键但服务不足的小儿肾脏的创新和高影响力的基准研究 疾病。对于更新，我们将急性肾脏损伤和狼疮性肾炎作为焦点区域。 当前的PCEN，并增加了肾纤维化的新焦点。具体目的包括：（1）吸引 在研究关键但服务不足的小儿肾脏疾病的研究中的出色专业知识，（2）促进 多学科研究关键但服务不足的小儿肾脏疾病的研究，（3）提供 高资源生物医学研究核心，以支持关键但服务不足的小儿肾脏的研究 疾病和（4）支持新颖的探索性试点研究，这将成为未来研究者的基础 启动申请。三个重点领域的每个重点领域提出了三个主要研究项目， 公认的跨学科调查员团队，投资组合约为100个联邦赠款。还包括 是高源基因表达，蛋白质组学，生物标志物和具有PI的行政核心 国际声望支持三个重点领域的研究。证据表明对 提出的核心旨在完成拟议的初级和试点研究补助金的目标。 提议的四个飞行员和可行性项目代表了多学科研究。 与高级调查员进行战略性配对以指导其职业的年轻调查员 通过独立研究者发射的应用开发。机构的大力支持证据 提供了领导力，机构CTSA和肾脏病T32培训补助金。 PCEN包括一个 15名调查人员的研究基础，每年的总体直接成本要求为75万美元。其他优势 包括CCHMC儿科肾脏科，具有巨大的临床量广度和深度， 资源和研究资金，并在三个焦点领域具有良好的记录记录。 应用程序。请勿使用4A，4B等后缀。