Biopsychosocial Mechanisms Linking Gender Minority Stress to HIV Comorbidities

将性别少数压力与艾滋病毒合并症联系起来的生物心理社会机制

基本信息

批准号：
9765399
负责人：
TONIA C POTEAT
金额：
$ 66.85万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765399
关键词：
Address Adult Anti-Retroviral Agents Appearance Behavioral Biological Biological Markers Cardiovascular Diseases Caring Chronic stress Clinical Comorbidity Complex Data Emotional Enrollment Epidemiologist Event Face Funding Gender Gender Identity Goals Gonadal Steroid Hormones HIV Health Health Promotion High Prevalence Immune Individual Infrastructure Intervention Interview Knowledge Laboratories Latina Link Longitudinal Studies Major Depressive Disorder Measures Mediating Mediator of activation protein Mental Health Metabolic Methods Neurosecretory Systems Outcome Participant Pathway interactions Pharmaceutical Preparations Physiological Physiology Population Poverty Prejudice Process Prospective Studies Prospective cohort Race Reporting Research Respondent Risk Risk Factors Role Scientist Severities Specimen Stress Structure Suicide attempt Surveys Symptoms United States United States National Institutes of Health Ursidae Family Viral Woman biopsychosocial cardiovascular disorder risk cigarette smoke clinical practice cohort ethnic minority population experience gender minority health disparity health equity high risk hormone therapy innovation intersectionality meetings mortality mortality risk multidisciplinary novel physical conditioning pressure protective factors psychological distress psychosocial public health relevance racial and ethnic racial minority social social stigma stem suicidal risk transgender transgender women

项目摘要

Project Summary/Abstract Despite a high prevalence of HIV among gender minority women, very little is known about HIV comorbid conditions in this population. Understanding the mechanisms of underlying HIV-related comorbidities in this health disparity population is an important step toward advancing health equity. The address this gap in knowledge, the study seeks to elucidate pathways linking stigma and physiologic stress to HIV comorbidities among Black and Latina gender minority women. The specific aims of the project include to: (1) quantify the longitudinal relationship of stigma to chronic stress biomarkers; (2) identify pathways linking chronic stress biomarkers to HIV comorbidities; and (3) examine the role of chronic stress in pathways linking stigma, sex hormones, and HIV comorbidities. These aims will be met using existing NIH-funded cohort platforms to enroll and follow 200 participants in a 24-month, mixed-methods, prospective study to measure stigma, biomarkers of chronic stress, sex hormones, mental health, and CVD risk. Data will be collected at baseline, 6-, 12-, 18-, and 24-months. This longitudinal study blends in-depth-interviews and quantitative psychosocial research with clinical and biological measures to advance understanding of the complex relationships between social experiences and physical health. This innovative research will identify mechanisms underlying associations between stigma and HIV comorbidities. It has important implications for interventions with health disparity populations living with HIV and will provide novel information that can be used to guide clinical practice and reduce health disparities.

项目摘要/摘要尽管性别少数妇女的艾滋病毒患病率很高，但对艾滋病毒的了解很少该人群的合并条件。了解基本HIV相关的机制这种健康差异人口的合并症是促进健康公平的重要一步。在知识方面的解决差距，该研究旨在阐明将污名和污名联系起来的途径黑人和拉丁裔性别少数妇女的艾滋病毒合并症的生理压力。具体该项目的目的包括：（1）量化污名与慢性应激的纵向关系生物标志物；（2）确定将慢性应激生物标志物与HIV合并症联系起来的途径；（3）检查慢性应激在关联污名，性激素和HIV合并症的途径中的作用。这些目标将使用现有的NIH资助的队列平台来招募并关注200名参与者在一项24个月的混合方法中，测量污名的前瞻性研究，慢性压力的生物标志物，性别激素，心理健康和CVD风险。数据将在基线，6-，12-，18和24个月时收集。这项纵向研究将深入介绍和定量的心理社会研究与临床融为一体和生物学措施，以提高对社会之间复杂关系的理解经验和身体健康。这项创新的研究将确定基本机制污名与艾滋病毒合并症之间的关联。它对干预措施具有重要意义健康差异人群患有艾滋病毒，将提供可用于指导的新颖信息临床实践并减少健康差异。