Craniofacial Growth Prediction in Different Facial Types

不同面部类型的颅面部生长预测

基本信息

批准号：
9893162
负责人：
Heesoo Oh
金额：
$ 11.62万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-02 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9893162
关键词：
Address Adolescent Adult Affect Age Age of Onset American Anatomy Area Categories Cervical Characteristics Child Childhood Chronology Classification Clinical Clinical Management Cluster Analysis Collection Complex Congenital Abnormality Craniofacial Abnormalities Data Data Analyses Databases Development Diagnosis Diagnostic Disease Dysmorphology Evaluation Evidence based treatment Face Feeling Foundations Future Goals Growth Growth Disorders Individual Information Dissemination Intervention Knowledge Lateral Least-Squares Analysis Length Measurement Methods Modeling Morphology National Institute of Dental and Craniofacial Research Nature Online Systems Operative Surgical Procedures Orthodontic Outcome Pathway interactions Patients Pattern Performance Polynomial Models Population Prevalence Puberty Reference Values Research Research Personnel Resources Sampling Structure Techniques Testing Treatment outcome Validation Variant Work base clinical diagnostics clinical practice clinically relevant clinically significant craniofacial density evidence base heuristics improved individual patient novel outcome prediction personalized predictions physical conditioning population health predictive modeling prognostic prognostic tool pubertal timing sex spine bone structure success tool trait treatment duration treatment optimization treatment planning vector web-based tool

项目摘要

Abstract Evidence-based pediatric practice requires a thorough understanding of growth in the absence of intervention. Proper treatment planning for craniofacial abnormalities in children and adolescents demands both an accurate assessment of a patient's current facial growth status and a prediction of future growth. Yet, current methods to derive this information are inadequate. Presently, there are no reference charts or practical tools for individualized assessment of these parameters that take into account not only sex and chronological age, but also facial type, cervical vertebral maturity, and past craniofacial measurements. We will identify landmarks on over 13,000 lateral cephalographs from 1,104 individuals, each with at least two observations before and after mid-puberty, for the purpose of building a model to predict the ages of onset, peak velocity, and cessation of pubertal craniofacial growth, and the amount of growth remaining for a given individual. Altogether, we will assess over 30,000 lateral cephalographs from 5,803 individuals, age 0-24 years for the purpose of constructing growth charts for multiple craniofacial traits. These data come from nine growth studies comprising the American Association of Orthodontists Foundation Legacy Collection. Through the analysis of these data, the proposed research will 1) estimate population- and individual-level timing of pubertal growth and adult size for multiple craniofacial traits, 2) provide diagnostic reference charts for craniofacial lengths, angles, and ratios given sex and age, 3) develop prognostic tools to predict remaining growth/change and the timing of the pubertal growth spurt for craniofacial traits, 4) make these valuable resources available to clinicians and researchers via an easy-to-use free web- based application, and 5) apply geometric morphometric techniques to extend current clinical views of quantifying craniofacial growth. The proposed research clearly addresses NIDCR's goal of integrating “clinical, and population health approaches to improve diagnostics and optimize outcomes.” At the completion of this project, clinical practice will be improved through the availability of easy-to-use web-based tools for diagnosing current status based on craniofacial measurements and predicting future growth based on current measurements, sex, age, facial type, cervical vertebral maturation, and past measurements. Additionally, scientific knowledge will be improved through the dissemination of information regarding population-level reference values for craniofacial lengths, angles, and ratios, and an evaluation of integrated craniofacial growth using geometric morphometric analysis. The overall impact of the proposed research will be a shift in the clinical management of pediatric craniofacial patients toward more evidence-based treatment planning, utilizing references and predictions based on data from the largest North American cephalometric collections.

抽象的基于证据的小儿实践需要在没有干涉。儿童和青少年的颅面异常的适当治疗计划要求对患者当前面部生长状况的准确评估以及对未来增长的预测。然而，目前，没有参考图表或实用方法来得出此信息不足。用于对这些参数进行个性化评估的工具，这些参数不仅考虑了性别和时间顺序年龄，也是面部型，颈椎成熟度以及过去的颅面测量。我们将确定来自1,104个人的13,000多个侧面头造影仪的地标，每个人都有AT 中期前后至少有两个观察结果，目的是建立一个模型来预测年龄开始，峰值的速度和悬浮青春期颅面生长的速度，以及A的生长量给予个人。总共，我们将评估来自5,803个人的30,000多个侧面头形，年龄为0-24岁为了为多种颅面特征构建生长图的目的。这些数据来自完成美国正畸医生协会的九项增长研究基金会遗产收藏。通过对这些数据的分析，拟议的研究将1）估计青春期生长和成人大小的种群和个人水平的时机，用于多种颅面特征，2）提供性别和年龄的颅面长度，角度和比率的诊断参考图表，3）预后的工具可以预测剩余的增长/变化以及青春期增长的时机突飞猛进特质，4）通过易于使用的免费网络，使临床医生和研究人员可获得这些宝贵的资源基于基于的应用，以及5）应用几何形态计量学技术来扩展量化颅面生长。拟议的研究清楚地解决了NIDCR整合“临床和人口健康的目标改善诊断和优化结果的方法。”该项目完成后，临床实践通过易于使用的基于Web的工具可用来改善用于诊断当前状态的工具基于当前的性别，年龄，面部类型，颅面测量并预测未来的增长，颈椎成熟和过去的测量值。此外，科学知识将得到改善通过传播有关颅面长度的人口水平参考值的信息，使用几何形态分析对颅面生长进行综合颅面生长的评估。拟议研究的总体影响将是转变的临床管理儿科颅面患者使用参考以及基于最大北美头孢胺集合收集的数据的预测。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bayesian approach to longitudinal craniofacial growth: The Craniofacial Growth Consortium Study.

DOI：
10.1002/ar.24520
发表时间：
2021-05
期刊：
Anatomical record (Hoboken, N.J. : 2007)
影响因子：
0
作者：
Sherwood RJ;Oh HS;Valiathan M;McNulty KP;Duren DL;Knigge RP;Hardin AM;Holzhauser CL;Middleton KM
通讯作者：
Middleton KM

Cross-sectional data accurately model longitudinal growth in the craniofacial skeleton.

DOI：
10.1038/s41598-023-46018-x
发表时间：
2023-11-07
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Middleton, Kevin M.;Duren, Dana L.;McNulty, Kieran P.;Oh, Heesoo;Valiathan, Manish;Sherwood, Richard J.
通讯作者：
Sherwood, Richard J.

Geometric morphometric analysis of growth patterns among facial types.

DOI：
10.1016/j.ajodo.2020.04.038
发表时间：
2021-09
期刊：
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
影响因子：
0
作者：
Knigge RP;McNulty KP;Oh H;Hardin AM;Leary EV;Duren DL;Valiathan M;Sherwood RJ
通讯作者：
Sherwood RJ

Estimating Craniofacial Growth Cessation: Comparison of Asymptote- and Rate-Based Methods.

DOI：
10.1177/10556656211002675
发表时间：
2022-03
期刊：
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
影响因子：
0
作者：
Hardin AM;Knigge RP;Oh HS;Valiathan M;Duren DL;McNulty KP;Middleton KM;Sherwood RJ
通讯作者：
Sherwood RJ

Craniofacial growth and morphology among intersecting clinical categories.

DOI：
10.1002/ar.24870
发表时间：
2022-09
期刊：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
影响因子：
2
作者：
Knigge, Ryan P.;Hardin, Anna M.;Middleton, Kevin M.;McNulty, Kieran P.;Oh, Hee Soo;Valiathan, Manish;Duren, Dana L.;Sherwood, Richard J.
通讯作者：
Sherwood, Richard J.