Research and Mentoring on Brain and Peripheral Bioenergetics in Schizophrenia

精神分裂症大脑和周围生物能量学的研究和指导

基本信息

批准号：
9763643
负责人：
Dost Ongur
金额：
$ 15.77万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763643
关键词：
ATP Synthesis Pathway Antipsychotic Agents Applications Grants Area Award Bioenergetics Bipolar Disorder Brain Brain imaging Caliber Clinical Clinical Investigator Clinical Research Data Development Diabetes Mellitus Educational process of instructing Ensure Environment Excess Mortality Exercise Faculty First Degree Relative Functional disorder Funding Future Genetic Glutamates Goals Grant Hospitals Individual Insulin Resistance Intervention Lead Link Lipids Literature Magnetic Resonance Spectroscopy Measures Mentors Mentorship Metabolic Metabolic syndrome Metabolism Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mitochondria Motivation Muscle National Institute of Mental Health Neurobiology Participant Patients Peripheral Pharmaceutical Preparations Phosphorus Photic Stimulation Process Production Productivity Protons Psychiatrist Psychotic Disorders Public Health Research Research Activity Research Personnel Research Proposals Research Training Resources Rest Role Rotation Schizophrenia Scientist Series Severities Soleus Muscle Techniques Time Training United States National Institutes of Health Visual Cortex Work Writing base brain abnormalities brain metabolism career career development cohort design first episode schizophrenia gamma-Aminobutyric Acid glucose metabolism in vivo information processing interest knowledge base meetings muscle metabolism neuroimaging neurotransmission next generation novel patient oriented research programs public health relevance recruit severe psychiatric disorder skills success therapeutic target tool white matter

ATP Synthesis Pathway Antipsychotic Agents Applications Grants Area Award Bioenergetics Bipolar Disorder Brain Brain imaging Caliber Clinical Clinical Investigator Clinical Research Data Development Diabetes Mellitus Educational process of instructing Ensure Environment Excess Mortality Exercise Faculty First Degree Relative Functional disorder Funding Future Genetic Glutamates Goals Grant Hospitals Individual Insulin Resistance Intervention Lead Link Lipids Literature Magnetic Resonance Spectroscopy Measures Mentors Mentorship Metabolic Metabolic syndrome Metabolism Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mitochondria Motivation Muscle National Institute of Mental Health Neurobiology Participant Patients Peripheral Pharmaceutical Preparations Phosphorus Photic Stimulation Process Production Productivity Protons Psychiatrist Psychotic Disorders Public Health Research Research Activity Research Personnel Research Proposals Research Training Resources Rest Role Rotation Schizophrenia Scientist Series Severities Soleus Muscle Techniques Time Training United States National Institutes of Health Visual Cortex Work Writing base brain abnormalities brain metabolism career career development cohort design first episode schizophrenia gamma-Aminobutyric Acid glucose metabolism in vivo information processing interest knowledge base meetings muscle metabolism neuroimaging neurotransmission next generation novel patient oriented research programs public health relevance recruit severe psychiatric disorder skills success therapeutic target tool white matter

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项目摘要

DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator in Patient Oriented Research award. I am a psychiatrist with clinical expertise in psychotic disorders and background in neurobiology. I have been conducting noninvasive neuroimaging studies probing cellular abnormalities in schizophrenia and bipolar disorder. I have built a group of junior investigators engaged in patient oriented research and I am the Chief of the Psychotic Disorders Division at McLean Hospital. However, I have a need for protected time to enhance my mentoring activities and to develop new areas of expertise to meet my long-term career goals of identifying therapeutic targets in psychotic disorders and to train the next generation of investigators in this field. In this proposal, I outline a mentoring lan for recruiting and retaining high caliber junior investigators into my research group. In addition,I will obtain additional training in mitochondrial function, brain bioenergetics, and peripheral glucose metabolism/diabetes. My research to date has examined abnormalities in glutamatergic and GABAergic neurotransmission. I will use this training to expand my studies into 31P magnetic resonance spectroscopy which provides detailed information about ATP synthesis and metabolism - processes which are intricately linked with neurotransmission. There are multiple indications that brain metabolism is also related to peripheral metabolism. Since patients with psychotic disorders are also prone to the metabolic syndrome, I will also initiate a new series of studies on muscle metabolism and peripheral markers of insulin resistance. I predict that these measures will correlate with brain measures, and they will suggest potential new opportunities for treating schizophrenia - an area of great unmet need.

描述（由应用程序提供）：这是针对患者研究奖的K24中级护理研究者的申请。我是一名精神科医生，具有精神病和神经生物学背景方面的临床专业知识。我一直在进行精神分裂症和双相情感障碍的细胞异常的无创神经影像学研究。我已经建立了一群从事以患者为导向的研究的初级调查人员，并且是麦克莱恩医院的精神病司司司。但是，我需要受到保护的时间来增强我的心理活动，并开发新的专业知识领域，以实现我的长期职业目标，即确定精神病中的治疗目标，并培训该领域的下一代研究人员。在此提案中，我概述了招募和留住高素质初级调查人员进入我的研究小组的心理LAN。此外，我还将获得有关线粒体功能，脑生物能学和周围葡萄糖代谢/糖尿病的其他培训。迄今为止，我的研究检查了谷氨酸能和GABA能神经传递的异常。我将使用此训练将研究扩展到31p磁共振光谱，该磁共振光谱提供了有关ATP合成和代谢的详细信息 - 与神经传递相关的过程。有多种迹象表明，脑代谢也与外周代谢有关。由于精神疾病的患者也容易发生代谢综合征，因此我还将开始一系列有关肌肉代谢和胰岛素抵抗的周围标记的新研究。我预测这些措施将与大脑测量相关，它们将为治疗精神分裂症的潜在新机会 - 一个巨大的未满足需求的领域。