The impact of obesity on cerebral energetics

肥胖对大脑能量学的影响

• 批准号: 9892003
• 负责人: Janice Jin Hwang
• 金额: $ 8.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9892003
• 关键词: AKT Signaling Pathway; Adult; Age; Animal Model; Animals; Appetitive Behavior; Automobile Driving; Blood - brain barrier anatomy; Brain; Calories; Cerebrum; Clinical; Closure by clamp; Complement; Coupled; Cues; Data; Defect; Diet Records; Eating Behavior; Feeling; Food; Foundations; Future; Genetic Transcription; Glucose; Glucose Transporter; Goals; High Fat Diet; Human; Hunger; Hyperglycemia; Impairment; Individual; Infusion procedures; Insulin Resistance; Kinetics; Lead; Link; Magnetic Resonance Spectroscopy; Measures; Mentored Patient-Oriented Research Career Development Award; Metabolism; Methodology; Modeling; Motivation; Neuraxis; Neurocognitive; Nonesterified Fatty Acids; Obesity; Overweight; Participant; Physiological; Plasma; Play; Questionnaires; Rattus; Research; Rodent; Rodent Model; Role; SLC2A1 gene; Satiation; Scanning; Signal Pathway; Signal Transduction; Standardization; Technology; Thinness; Translations; Visual; animal data; frontal lobe; glucose metabolism; glucose transport; glucose uptake; human data; insight; metabolic phenotype; neuroimaging; obesity development; oxidation; prevent; regional difference; response; skills; translational research program; translational study

Project summary There is a growing body of evidence that obesity is associated with reduced cerebral metabolism; however, the underlying mechanisms and the functional clinical implications of these observations remain unclear. The central goal of this project is to investigate a finding we have recently made that obesity is associated with decreased transport capacity for glucose across the blood-brain barrier. This proposal uses state of the art neuroimaging technology coupled with classic human metabolic phenotyping methodologies to investigate the underlying mechanisms behind how the brain is impacted by obesity. Because the brain is exquisitely sensitive to circulating glucose levels, the findings from this proposed study will help clarify how diminished brain glucose transport in obesity may lead to diminished post-prandial satiety signaling and/or be a potential mechanism for the neurocognitive consequences of obesity. The proposed studies in this R03 proposal will lay the foundation for future studies targeting brain glucose transport and metabolism alterations to treat and prevent the central nervous system complications of obesity.

项目摘要 越来越多的证据表明肥胖与大脑代谢减少有关。但是， 这些观察结果的基本机制和功能性临床意义尚不清楚。这 该项目的核心目标是调查我们最近提出的肥胖与肥胖有关的发现 在血脑屏障上葡萄糖的运输能力降低。该建议使用艺术状态 神经影像技术以及经典的人类代谢表型方法的研究 大脑如何受到肥胖的影响背后的基本机制。因为大脑非常敏感 为了循环葡萄糖水平，这项拟议的研究的发现将有助于阐明大脑的减少方式 肥胖症中的葡萄糖转运可能导致餐后饱腹感信号降低和/或成为潜力 肥胖的神经认知后果的机制。 R03提案中的拟议研究将提出 针对脑葡萄糖传输和代谢改变以治疗和治疗的未来研究的基础 防止肥胖的中枢神经系统并发症。