Neuroimaging of Mechanisms Subserving Cognitive and Social Outcomes in Childhood TBI

儿童 TBI 中促进认知和社会结果的机制的神经影像学

基本信息

批准号：
9765048
负责人：
Kristen Robinson Hoskinson
金额：
$ 12.42万
依托单位：
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-23 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765048
关键词：
15 year old Adaptive Behaviors Address Adolescent Affect Anisotropy Anterior Area Award Behavioral Brain Brain Injuries Brain imaging Brain region Cause of Death Child Childhood Clinical Clinical Psychology Cognitive Cognitive deficits Development Plans Diffusion Diffusion Magnetic Resonance Imaging Early identification Emotional Etiology Evaluation Face Faculty Foundations Functional Magnetic Resonance Imaging Funding Goals Image Individual Injury Instruction Intervention Knowledge Lead Link Measures Medial Mentored Research Scientist Development Award Mentors Mentorship Methodology Methods Mind Modeling Morbidity - disease rate Neurologic Neuropsychology Orthopedics Outcome Parents Parietal Pattern Plant Roots Psyche structure Quality of life Reporting Research Research Methodology Research Personnel Research Project Grants Research Support Risk Sampling Schools Scientist Services Short-Term Memory Social Adjustment Social Behavior Social Functioning Statistical Data Interpretation Statistical Methods Statistical Models Structure System Task Performances Techniques Training Traumatic Brain Injury Validation base behavioral neurology brain pathway career career development cognitive function cognitive neuroscience cognitive task comparison group disability executive function experience improved improved outcome innovation insight neuroimaging neuromechanism novel outcome prediction pediatric traumatic brain injury peer programs prospective public health relevance relating to nervous system remediation research and development response skill acquisition skills social social cognition social neuroscience success theories therapy development white matter

项目摘要

DESCRIPTION (provided by applicant): Dr. Kristen Robinson's long-term career goal is to become an accomplished clinical scientist with a program of research aimed at the early identification of children most at risk for cognitive, social, and adaptive morbidities following childhood brain injury. This mentored research scientist development award (K01) proposal outlines career development and research plans that will ultimately lead to Dr. Robinson becoming a successful independent investigator in pediatric neuropsychology. Dr. Robinson will pursue a career development plan that focuses on the continued acquisition of skills necessary to obtain her career goals, through a set of mentored research experiences. Dr. Robinson will obtain intensive training in cutting-edge neuroimaging methods that assess brain pathways and functional networks, ecologically- valid "real-world" assessment of social functioning, and advanced multi-method statistical modeling, as well as instruction in aspects of behavioral neurology. She will complete her training under the mentorship of a skilled and established team of mentors and collaborators with extensive expertise and success in guiding trainees and junior faculty to successful careers as independent clinical scientists. She will benefit from state-of-the-art neuroimaging facilities and extensive support from research core services. The new research and analytical skills she acquires during the award period will enhance her existing abilities and build upon her strong foundation in clinical psychology, pediatric neuropsychology, and social neuroscience. The long-term objectives of the research project are to improve social outcomes for children following traumatic brain injury (TBI) by identifying the neural mechanisms that underlie executive function and social cognitive deficits and identifying how those mechanisms are associated with social behavior, peer relationships, and classroom social adjustment. The study will involve 8- to 15- year old children with moderate to severe TBI (n=30) and a comparison group of children with orthopedic injury (OI; n=30). Research methods will include diffusion tensor imaging, functional and connectivity imaging, as well as ecologically-valid school based assessment, and will address two main research aims: a) to identify differences and similarities in the neural substrates underlying executive and social- cognitive functioning in children with TBI relative to children with OI; and b) to explore associations among brain structure, functional activation, social functioning, and adaptive outcome. Statistical analyses will assess the similarities and differences in patterns of brain activation and white matter integrity across groups, and will assess the associations among these indicators of brain structural and functional integrity with social behavior, peer relationships, and social adjustment in the classroom. Assessment of these relationships is necessary to inform the development of interventions to remediate the social difficulties children face after TBI.

描述（由申请人提供）：克里斯汀·罗宾逊博士的长期职业目标是成为一名有成就的临床科学家，其研究计划旨在及早识别儿童脑损伤后最容易罹患认知、社会和适应性疾病的儿童这项受指导的研究科学家发展奖 (K01) 提案概述了职业发展和研究计划，最终将使罗宾逊博士成为一名成功的儿科神经心理学独立研究者。罗宾逊博士将追求一个专注于持续获得技能的职业发展计划。通过一系列受指导的研究经验，罗宾逊博士将获得有关评估大脑通路和功能网络、生态上有效的“现实世界”社会功能评估的强化培训。她将在熟练且成熟的导师和合作者团队的指导下完成高级多方法统计建模以及行为神经学方面的指导，他们拥有丰富的专业知识并成功指导学员和初级教师取得成功的职业生涯。她将受益于独立的临床科学家。最先进的神经影像设施以及她在获奖期间获得的新研究和分析技能的广泛支持将增强她现有的能力，并建立在她在临床心理学、儿科神经心理学和社会神经科学方面的坚实基础上。该研究项目的长期目标是通过确定执行功能和社会认知缺陷背后的神经机制，并确定这些机制如何与社会行为、同伴关系、和课堂社会适应。将涉及患有中度至重度 TBI 的 8 至 15 岁儿童（n = 30）和骨科损伤儿童对照组（OI；n = 30）。研究方法将包括弥散张量成像、功能和连接成像、以及生态有效的学校评估，并将解决两个主要研究目标：a）确定 TBI 儿童与 OI 儿童执行和社会认知功能的神经基质的差异和相似性；探索关联之中大脑结构、功能激活、社会功能和适应性结果将评估不同群体的大脑激活模式和白质完整性的相似性和差异，并将评估这些大脑结构和功能完整性指标与社会行为之间的关联。、同伴关系和社会适应在课堂上评估这些关系对于制定干预措施以纠正 TBI 后儿童面临的社交困难是必要的。