Integrative Center for Environmental Microbiomes and Human Health

环境微生物组与人类健康综合中心

基本信息

批准号：
9764433
负责人：
MARGARET J MC FALL-NGAI
金额：
$ 204.64万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9764433
关键词：
Address Affect Animals Bioinformatics Biological Sciences Biology Centers of Research Excellence Characteristics Communities Core Facility Country Dedications Development Ecosystem Environment Environmental Health Exposure to Faculty Fostering Funding Future Generations Genetic Genomics Geographic Locations Goals Growth Habitats Hawaiian population Health Home environment Human Human Microbiome Human Resources Human body Indigenous Infrastructure Insect Vectors Interdisciplinary Study Invertebrates Investigation Island Laboratories Leadership Mentorship Methods Microbe Microscope Modeling Molecular Native Hawaiian Observational Study Pathogenicity Phase Planet Earth Planets Play Quality of life Research Research Personnel Role Science Scientist Sea Senior Scientist Shapes Students Talents Technology Training United States National Institutes of Health Universities Vector-transmitted infectious disease Vision Work base cohort design disease transmission frontier healthspan innovation insight instrumentation land use microbial microbial community microbiome microbiome research microscopic imaging outreach pathogenic microbe predictive modeling professor programs recruit response rural setting success tenure track tool urban setting

Address Affect Animals Bioinformatics Biological Sciences Biology Centers of Research Excellence Characteristics Communities Core Facility Country Dedications Development Ecosystem Environment Environmental Health Exposure to Faculty Fostering Funding Future Generations Genetic Genomics Geographic Locations Goals Growth Habitats Hawaiian population Health Home environment Human Human Microbiome Human Resources Human body Indigenous Infrastructure Insect Vectors Interdisciplinary Study Invertebrates Investigation Island Laboratories Leadership Mentorship Methods Microbe Microscope Modeling Molecular Native Hawaiian Observational Study Pathogenicity Phase Planet Earth Planets Play Quality of life Research Research Personnel Role Science Scientist Sea Senior Scientist Shapes Students Talents Technology Training United States National Institutes of Health Universities Vector-transmitted infectious disease Vision Work base cohort design disease transmission frontier healthspan innovation insight instrumentation land use microbial microbial community microbiome microbiome research microscopic imaging outreach pathogenic microbe predictive modeling professor programs recruit response rural setting success tenure track tool urban setting

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项目摘要

Project Summary – OVERALL The goal of the proposed COBRE program is to create an Integrative Center for Environmental Microbiomes and Human Health (ICEMHH) in response to the 2016 announcement of the National Microbiome Initiative (NMI). The NMI was conceived through the recognition that humans are both connected to and reliant upon the microbial communities that constitute the Earth's microbiomes, in the environment as well as the human body. The NIH plays a central role in funding this effort, “..with a particular emphasis on multi-ecosystem comparison studies, and investigation into the design of new tools to explore and understand microbiomes” [NIH Human Microbiome Project]. The focus of ICEMHH is the interface between the microbial environment and human health, and spans state-of-the-art `-omics' methods to ecological analyses and predictive models. The University of Hawaiʻi brings three compelling strengths to microbiome research: the uniquely tractable and scalable landscape of the Hawaiian Islands, an exceptionally qualified biology faculty, including an integrated cohort of recently hired, microbiome-focused, tenure-track, junior professors, and a dedication to the diversity of people that live on the Islands. As the most diverse biome on Earth, Hawaiʻi offers the opportunity to study the effects of ecological gradients on human health, from mountain to sea, and in both urban and rural settings. The proposed projects aim to address two critical and intertwined health problems: the deteriorating environment, and the current spread of insect-vector borne diseases. In this context, proposed research efforts will (i) explore how human health is impacted by exposure to pathogenic microbes in the environment; (ii) examine how the microbiomes of insect vectors affect their transmission of disease within the microcosm of the island of Oʻahu; and, (iii) exploit invertebrate models to provide insight into the underlying cellular, genetic and molecular mechanisms by which microbiomes confer health. In this way, the Center will provide lasting contributions to the State of Hawaiʻi, and beyond.

项目摘要 - 总体拟议的毛线计划的目的是为环境创建一个综合中心微生物和人类健康（ICEMHH）应对2016年国民宣布微生物组倡议（NMI）。 NMI是通过认识到人类都相互联系的。在环境中，并依靠构成地球微生物组的微生物群落以及人体。 NIH在资助这项工作中起着核心作用：“ ..特别强调多生态系统比较研究以及对探索和理解的新工具设计的投资微生物组” [NIH人类微生物组项目]。iCEMHH的重点是微生物之间的接口环境与人类健康，并跨越生态分析的最先进的“ - 词”方法预测模型。夏威夷大学为微生物组研究带来了三种令人信服的优势：夏威夷群岛的独特典型和可扩展的景观，这是一个非常有资格的生物学教师包括最近雇用的综合队列，以微生物组为中心，终身教授，初中教授和致力于居住在岛屿上的人们的多样性。作为地球上最潜水的生物群落，夏威夷提供了研究生态梯度对人类健康的影响，从山到海，以及在城市和粗糙环境中。拟议的项目旨在解决两个关键和交织在一起的健康问题：环境恶化以及绝缘载体传播疾病的当前传播。在这个上下文，拟议的研究工作将（i）探讨暴露于致病性的人类健康如何影响环境中的微生物；（ii）检查昆虫向量的微生物组如何影响其传播瓦胡岛岛上的疾病；以及（iii）利用无脊椎动物模型，以提供有关微生物赋予健康的潜在细胞，遗传和分子机制。这样，该中心将为夏威夷及以后的州提供持久的贡献。