Retinal/choroidal imaging with transcranial back-illumination

经颅背照式视网膜/脉络膜成像

基本信息

批准号：
9762120
负责人：
Jerome Mertz
金额：
$ 20.63万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762120
关键词：
Age related macular degeneration Appearance Attenuated Back Biological Markers Cardiac Choroid Clinic Clinical Color Cornea Data Devices Diagnosis Diffuse Eye Fundus Fundus photography Geometry Glare Goals Hemoglobin Human Image Imagery Imaging technology Light Lighting Lipids Macular degeneration Maps Medical center Melanins Methods Modality Mydriasis New England Ophthalmoscopes Optic Disk Optical Coherence Tomography Optics Oxygen Penetration Performance Process Property Pupil Records Recovery Rest Retina Retinal Stimulus Structure Structure of retinal pigment epithelium System Techniques Tissues Uncertainty absorption base bone chromophore contrast imaging cranium design design and construction early screening experience eye center fundus imaging hemodynamics imager imaging modality macula movie novel real time monitoring response retinal imaging screening sensor time use transmission process volunteer

项目摘要

ABSTRACT Human retinal imaging is conventionally performed with a fundus camera, which sends light into the subject’s eye and records images of the light reflected from the retina. Our goal is to develop an alternative imaging strategy based on light delivered transcranially through the subject’s temple. The light diffuses through the bone and illuminates the retina not from the front, as in a standard fundus camera, but rather mostly from the back. As such, we image light transmitted through the retina rather than reflected from the retina. In addition to being glare-free and allowing deeper image penetration well into the choroid, we hypothesize that transmitted-light imaging reveals qualitatively different tissue structure than reflected-light imaging. Our strategy will be compatible with existing fundus cameras, enabling transmission and reflection modalities to be operated quasi-simultaneously, allowing a direct comparison of the two modalities and a potential fusion of the information they provide. Specifically, we propose to equip our device with eight different LED illumination wavelengths, any two of which can be operated simultaneously, from which we propose to identify a variety of chromophore distributions such as oxy- and deoxy-hemoglobin and melanin. We hypothesize that such chromophore mapping over extended depths will provide valuable information useful for the potential diagnosis and study of macular degeneration, and for the real-time monitoring of hemodynamics. To gauge the performance of our device and its potential utility in the clinic, we have enlisted the help of Dr. Elias Reichel at the Tufts Medical Center, who has clinical experience with both fundus and OCT imaging.

抽象的人类视网膜成像通常使用眼底摄像头进行，该相机将光线发送到受试者的眼睛和记录了从视网膜反射的光的图像。我们的目标是发展一种基于通过主题经经颅传递的光传递的替代成像策略寺庙。光线通过骨骼扩散并从前面照亮视网膜，例如标准的眼底摄像头，但大部分是从背面进行的。因此，我们图像传输的光通过视网膜而不是从视网膜中反射。除了无眩光和使更深的图像很好地渗透到脉络膜中，我们假设发射光线成像揭示了与反射光成像的质量不同的组织结构。我们的策略将与现有的眼底摄像机兼容，实现传输和反射方式要进行准单行操作，从而直接比较两种方式和它们提供的信息的潜在融合。具体而言，我们建议将设备配备八个不同的LED照明波长，其中任何两个都可以简单地操作，我们建议从中确定各种各样的发色团分布，例如氧和脱氧血红蛋白和黑色素。我们假设这样的发色团映射在扩展的深度上将提供有价值的信息用于潜在的诊断和研究黄斑变性以及实时监测血液动力学。为了衡量我们的设备的性能及其在诊所中的潜在效用，我们已经在塔夫茨医学中心的Elias Reichel博士的帮助具有眼底和OCT成像的经验。