Retinal/choroidal imaging with transcranial back-illumination

经颅背照式视网膜/脉络膜成像

基本信息

批准号：
9762120
负责人：
Jerome Mertz
金额：
$ 20.63万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762120
关键词：
Age related macular degeneration Appearance Attenuated Back Biological Markers Cardiac Choroid Clinic Clinical Color Cornea Data Devices Diagnosis Diffuse Eye Fundus Fundus photography Geometry Glare Goals Hemoglobin Human Image Imagery Imaging technology Light Lighting Lipids Macular degeneration Maps Medical center Melanins Methods Modality Mydriasis New England Ophthalmoscopes Optic Disk Optical Coherence Tomography Optics Oxygen Penetration Performance Process Property Pupil Records Recovery Rest Retina Retinal Stimulus Structure Structure of retinal pigment epithelium System Techniques Tissues Uncertainty absorption base bone chromophore contrast imaging cranium design design and construction early screening experience eye center fundus imaging hemodynamics imager imaging modality macula movie novel real time monitoring response retinal imaging screening sensor time use transmission process volunteer

项目摘要

ABSTRACT Human retinal imaging is conventionally performed with a fundus camera, which sends light into the subject’s eye and records images of the light reflected from the retina. Our goal is to develop an alternative imaging strategy based on light delivered transcranially through the subject’s temple. The light diffuses through the bone and illuminates the retina not from the front, as in a standard fundus camera, but rather mostly from the back. As such, we image light transmitted through the retina rather than reflected from the retina. In addition to being glare-free and allowing deeper image penetration well into the choroid, we hypothesize that transmitted-light imaging reveals qualitatively different tissue structure than reflected-light imaging. Our strategy will be compatible with existing fundus cameras, enabling transmission and reflection modalities to be operated quasi-simultaneously, allowing a direct comparison of the two modalities and a potential fusion of the information they provide. Specifically, we propose to equip our device with eight different LED illumination wavelengths, any two of which can be operated simultaneously, from which we propose to identify a variety of chromophore distributions such as oxy- and deoxy-hemoglobin and melanin. We hypothesize that such chromophore mapping over extended depths will provide valuable information useful for the potential diagnosis and study of macular degeneration, and for the real-time monitoring of hemodynamics. To gauge the performance of our device and its potential utility in the clinic, we have enlisted the help of Dr. Elias Reichel at the Tufts Medical Center, who has clinical experience with both fundus and OCT imaging.

抽象的人类视网膜成像通常使用眼底相机进行，该相机将光线发送到我们的目标是开发受试者的眼睛并记录从视网膜反射的光的图像。基于通过受试者的经颅传递的光的替代成像策略光线穿过骨骼扩散并照亮视网膜，而不是像在太阳穴中那样从前面照射。标准眼底相机，但主要是从背面拍摄，因此我们对透射的光进行成像。透过视网膜而不是从视网膜反射。为了让图像更深入地渗透到脉络膜中，我们合作了透射光成像揭示了与反射光成像不同的组织结构。将与现有眼底相机兼容，实现透射和反射模式准同时操作，允许直接比较两种模式和他们提供的信息的潜在融合。具体来说，我们建议为我们的设备配备八种不同的 LED 照明波长，其中任何两个都可以同时操作，我们建议从中识别出各种发色团分布，例如氧合血红蛋白和脱氧血红蛋白以及黑色素。这种在扩展深度上的发色团映射将提供有用的有价值的信息用于黄斑变性的潜在诊断和研究以及实时监测为了衡量我们设备的性能及其在临床中的潜在用途，我们得到了塔夫茨医疗中心 Elias Reichel 博士的帮助，他拥有临床经验具有眼底和 OCT 成像经验。