Investigating Pain Processing in the Brain, Brainstem, and Spinal Cord with fMRI

用功能磁共振成像研究大脑、脑干和脊髓的疼痛处理

基本信息

批准号：
8774569
负责人：
Kenneth Arnold Weber
金额：
$ 6.63万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-12-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8774569
关键词：
Acute Pain Age Area Brain Brain Stem Brain imaging Brain region Brain scan Career Choice Cervical spinal cord structure Characteristics Chronic Chronic low back pain Chronic neck pain Clinical Clinical Trials Data Data Collection Development Devices Dimensions Economic Burden Elderly Experimental Designs Functional Imaging Functional Magnetic Resonance Imaging Future Goals Healthcare Systems Household Image Analysis Imaging Techniques Individual Investigation Lead Magnetic Resonance Imaging Measurement Measures Medical Imaging Mentors Methods Morphologic artifacts Musculoskeletal Pain National Research Service Awards Nervous system structure Neuraxis Neurons Neurosciences Nociception Pain Pain intensity Patients Pattern Perception Physics Plague Population Postdoctoral Fellow Prevalence Process Recruitment Activity Research Research Design Research Personnel Role Scanning Scientist Signal Transduction Skin Societies Spinal Spinal Cord Stimulus Syndrome Time Training United States Upper Extremity Variant Water Work base chronic pain computerized effective therapy emotional distress experimental analysis extracellular human subject neural patterning novel relating to nervous system spontaneous pain statistics technical writing treatment effect treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Chronic pain syndromes remain a widespread problem in the United States. Chronic pain causes much suffering and places a large economic burden on the health care system. Recent advancements in brain imaging techniques are increasing our understanding of the role of the brain in the perpetuation of chronic pain. These studies are beginning to decode the neural substrates underlying chronic pain states. Using functional magnetic resonance imaging (fMRI), our group has demonstrated distinct temporal and spatial disturbances in brain activity in chronic pain states such as chronic low back pain. The principal goal of the proposed project is to expand on our previous fMRI pain studies and investigate pain processing along the entire neuraxis. The proposed research aims to utilize fMRI to further characterize and understand pain-related neural activity at the level of the brain, brainstem, and spinal cord in both healthy subjects and chronic neck pain patients. Overall, this information will increase our understanding of pain processing and further characterize the neural substrates underlying chronic neck pain. Specifically, our team intends to use these results in the future to properly design studies using fMRI to measure treatment-induced changes in pain-related brain, brainstem, and spinal cord activity.

描述（由申请人提供）：慢性疼痛综合征在美国仍然是一个普遍存在的问题。慢性疼痛会造成很多痛苦，并给医疗保健系统带来巨大的经济负担。脑成像技术的最新进展正在加深我们对大脑在慢性疼痛持续存在中的作用的理解。这些研究开始解码慢性疼痛状态背后的神经基质。使用功能磁共振成像（fMRI），我们的团队证明了慢性疼痛状态（例如慢性腰痛）的大脑活动存在明显的时间和空间紊乱。该项目的主要目标是扩展我们之前的功能磁共振成像疼痛研究，并研究整个神经轴的疼痛处理。拟议的研究旨在利用功能磁共振成像进一步表征和理解大脑层面与疼痛相关的神经活动，健康受试者和慢性颈痛患者的脑干和脊髓。总的来说，这些信息将增加我们对疼痛处理的理解，并进一步表征慢性颈部疼痛背后的神经基质。具体来说，我们的团队打算在未来利用这些结果来正确设计使用功能磁共振成像的研究，以测量治疗引起的与疼痛相关的大脑、脑干和脊髓活动的变化。