Mechanisms of Membrane Transport GRC 2019

膜传输机制 GRC 2019

基本信息

批准号：
9761723
负责人：
Olga Boudker
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9761723
关键词：
Academia Affect Brain Career Choice Carrier Proteins Cell Survival Cell membrane Cells Cellular Membrane Cryoelectron Microscopy Crystallography Development Disease Ensure Environment Epilepsy Evolution Financial Support Fostering Functional disorder Future Health Heart Human Human body Individual Ion Channel Link Lipid Bilayers Mediating Membrane Membrane Proteins Membrane Transport Proteins Mental disorders Mentors Methods Mission Molecular Motion Movement Mutation Myocardial dysfunction Nerve Degeneration Organism Pathologic Pathology Pharmacology Physiological Physiology Postdoctoral Fellow Protein Dynamics Proteins Research Research Personnel Role Running Sampling Scientist Seasons Senior Scientist Series Sex Bias Shapes Structure Students Training Transmembrane Transport United States National Institutes of Health Work addiction base biophysical techniques body system career cohort experimental study graduate student insight intercellular communication kidney dysfunction meetings nervous system disorder neurotransmission novel therapeutics physical property posters programs protein folding protein function protein metabolism protein transport recruit symposium

项目摘要

Project Summary The Mechanisms of Membrane Transport GRC has been running since 1966. The mission of the GRC is to advance the understanding of ion channels and transporters at the structural, mechanistic and physiological levels. The channels and transporters are fundamental to the physiology of all cells and organisms and their dysfunction is associated with numerous diseases affecting every organ system in the human body. They are of particular importance in the brain, where they mediate all aspects of neurotransmission. Even subtle dysregulation of these proteins due to mutations or pathological conditions leads to devastating human conditions such as epilepsy, neurodegeneration, addiction, and mental disorders. In depth understanding of their mechanisms opens novel therapeutic strategies and increases their utility as pharmacological targets. The 2019 GRC, subtitled “From evolution and folding to new concepts in health and disease” aims to generate vigorous discussions with a specific emphasis on exploring avenues of rigorous mechanistic studies of membrane transport proteins within the context of their physiologic environments and in view of their specific roles in cells. The GRC also aims to provide an effective forum promoting junior researchers and facilitating their career choices. A Gordon Research Seminar will run in conjuncture with the GRC, organized by junior investigators and trainees during the preceding two days. 2019 GRS will serve to promote scientific research by junior attendees and to further NIH training priorities through discussions of career options and strategies, and of gender biases in academia. !

项目摘要膜运输GRC的机制自1966年以来一直在运行。 GRC是要在结构上促进对离子通道和转运蛋白的理解，机械和物理水平。渠道和运输商是所有细胞和组织的生理学及其功能障碍都与许多影响人体每个器官系统的疾病。他们在大脑，它们介导神经传递的各个方面。甚至微妙的失调这些由于突变或病理状况引起的蛋白质导致人类毁灭性的人癫痫，神经退行性，成瘾和精神障碍等疾病。深度了解其机制开辟了新型的热策略并增加了效用作为药物目标。 2019年GRC，字幕为“从进化和折叠到新的健康和疾病的概念”旨在引起激烈的讨论，以特定的重点探索膜转运蛋白的严格机理研究途径鉴于它们在细胞中的特定作用，其生理环境的背景。 GRC 还旨在提供一个有效的论坛来促进初级研究人员并支持其职业选择。 Gordon研究研讨会将与GRC一起进行，由Junior组织在前两天的调查人员和学员。 2019年GRS将有助于促进初级与会者的科学研究，并通过讨论进一步的NIH培训优先级职业选择和策略以及学术界的性别偏见。呢