Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 8692750
• 负责人: Yingchun Zhang
• 金额: $ 23.06万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692750
• 关键词: Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel

As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women.

作为重新提交，拟议的五年计划将培训我并促进我成为独立的 跨学科研究生涯。我在生物医学工程、电气方面的多学科背景 工程和机械工程领域以及我在先进生物力学方面的杰出经验 建模和电生理建模研究培养了我的兴趣并赋予我独特的能力 在尿失禁（UI）领域进行跨学科生物医学研究的优势。即时的 目标是为独立科学家的职业生涯做好准备，并开发一种新颖的特定学科 基于机电骨盆模型的尿道阴道支持和尿道功能评估（UUFA） 技术来微创和定量评估这两个病因并调查 与衰老效应相关的特定变化导致女性 SUI 患病率增加。这 这项研究背后的中心假设是女性的尿道阴道支持和尿道功能 可以通过微创和定量评估衰老对女性 SUI 的影响 使用特定于主题的骨盆建模方法来表征。主要假设#1 是尿道 可以使用针对特定对象的方法对女性的功能进行微创和定量评估 电生理盆腔建模方法。主要假设#2 是尿道阴道支持功能 可以使用特定主题的骨盆生物力学对女性进行非侵入性定量评估 建模方法。主要假设#3 是衰老会导致尿道阴道支持和/或尿道功能不良 功能障碍，从而导致 SUI。主要假设#4 是可以创建女性节制概况 临床上预测女性的节制状况，并提出最佳治疗方式 特定患者。我们提出四个具体目标 (SA) 来检验这些假设： SA #1：开发一个主题 - 基于特定电生理骨盆模型的尿道周围肌肉疲劳评估（UMFA）技术 微创定量评估女性尿道功能。主要假设#1 将得到检验。 SA #2：开发基于尿道阴道支持功能的特定主题生物力学骨盆模型 评估（USFA）技术，用于非侵入性和定量评估尿道阴道支持功能 女性。主要假设#2 将得到检验。 SA #3：研究衰老对尿道功能的影响 使用 UUFA 技术对患有/不患有 SUI 的年轻/老年女性受试者进行尿道阴道支持 由 UMFA 和 USFA 技术组成。主要假设#3 将得到检验。 SA #4：开发一个 女性SUI概况作为女性SUI的临床标准，利用UUFA技术定量 描述女性尿道阴道支持和尿道功能中 SUI 病因的特征。主要假设 #4 将被测试。在该项目完成时，我们期望我们将建立并 验证了UUFA技术及其在临床研究中应用的可行性，并取得了 更好地了解与衰老和更年期相关的具体变化对这些变化的贡献 女性的病因因素。