Optimizing postoperative cognition in the elderly

优化老年人术后认知

• 批准号: 9473731
• 负责人: Stacie Deiner
• 金额: $ 17.25万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9473731
• 关键词: Activities of Daily Living; American; Anesthesia procedures; Anesthetics; Area; Area Analyses; Award; Brain; Classification; Clinical Research; Clinical Trials; Cognition; Cognitive; Complication; Computers; Conduct Clinical Trials; Data; Data Quality; Delirium; Development; Drug usage; Elderly; Electroencephalography; Epidemiology; Evolution; Executive Dysfunction; Frequencies; Functional disorder; Goals; Grant; Health; Hospitals; Impaired cognition; Impairment; Learning; Light; Link; Literature; Measurement; Measures; Memory; Memory impairment; Mentorship; Methodology; Monitor; Nature; Neuropsychological Tests; Neuropsychology; Operating Rooms; Operative Surgical Procedures; Outcome; Patients; Performance; Perioperative; Positioning Attribute; Postoperative Period; Prevention; Process; Process Measure; Prospective cohort study; Research; Research Personnel; Research Project Grants; Role; Suggestion; Syndrome; Technology; Time; Training; base; career; cognitive testing; design; evidence based guidelines; executive function; functional decline; functional disability; human old age (65+); improved; instrument; instrumental activity of daily living; interest; mortality; neurocognitive test; novel; older patient; post-operative cognitive dysfunction; prevent; public health relevance; recruit; response; signal processing; skills

 DESCRIPTION (provided by applicant): I am a neurosurgical anesthesiologist with research interests focused on perioperative cognitive dysfunction (POCD) and delirium in geriatric surgical patients. The Beeson Award represents a unique opportunity to attain the skills I will need to become an independent investigator in perioperative geriatric cognition. The research project we have designed for the award period is a prospective cohort study to identify the level of anesthetic depth which may be protective for POCD. For maximal sensitivity we will examine dysfunction in the domains of executive function and memory, and measure the impact of POCD on independent activities of daily living after surgery. This project is based on my pilot data and suggestions from the existing literature that anesthetic depth influences occurrence of POCD, and that POCD in turn influences the occurrence of impairment in activities of daily living. In the short term, this Award period will provide me the opportunity to become an expert in cognition in the elderly, deepen my understanding of monitoring the brain using processed EEG, and learn to quantify function using validated geriatric specific instruments. I will complete coursework in the areas of analysis of cognitive testing, the conduct of clinical research and clinical trials, and epidemiology and prevention methodology in the elderly. My long term goal is create opportunities for anesthesiologists to improve cognitive outcomes for older adults in the perioperative period.

 描述（由适用提供）：我是一名神经外科麻醉师，研究兴趣的研究兴趣侧重于周期性认知功能障碍（POCD）和老年手术患者的del妄。 Beeson Award代表了一个独特的机会来获得我将成为定期老年认知独立调查员所需的技能。我们为颁奖期设计的研究项目是一项前瞻性队列研究，旨在确定可以保护POCD的麻醉深度水平。为了最大程度的敏感性，我们将检查执行功能和记忆域中的功能障碍，并衡量POCD对手术后日常生活独立活动的影响。该项目基于我的试点数据和现有文献的建议，即麻醉深度会影响POCD发生，而POCD反过来又影响了日常生活活动的损害。在短期内，这个奖励期将为我提供最古老的认知专家的机会，加深了我使用经过处理的脑电图对大脑进行监控的理解，并学习使用经过验证的老年特定特定特定特定的仪器来量化功能。我会完成的 认知测试分析领域的课程工作，临床研究和临床试验的进行以及年龄较大的流行病学和预防方法。我的长期目标是为麻醉师创造机会，以在周期期间改善老年人的认知结果。