Effects of physical activity on brain function and network connectivity in MCI

体力活动对 MCI 患者大脑功能和网络连接的影响

基本信息

批准号：
9478836
负责人：
Judy Pa
金额：
$ 56.78万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9478836
关键词：
Activities of Daily Living Aerobic Aerobic Exercise Affect Age-Years Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid Biological Markers Blood Brain Brain-Derived Neurotrophic Factor Clinical Clinical Trials Clinical dementia rating scale Cognition Cognitive Disease Disease Progression Early Intervention Early treatment Elderly Exercise Functional Magnetic Resonance Imaging Functional disorder Goals Health education Hippocampus (Brain)Home environment Hyperactive behavior Impaired cognition Impairment Individual Insulin-Like Growth Factor I Intervention Investments MRI Scans Maintenance Maps Measurement Measures Memory Methodology Methods Modernization Onset of illness Outcome Outcome Measure Oxygen Consumption Participant Pathology Patients Pharmacology Physical activity Positron-Emission Tomography Prefrontal Cortex Process Randomized Randomized Controlled Trials Recommendation Rest Risk Scanning Serum Signal Transduction Somatostatin Stretching Surgeon Testing United States National Institutes of Health Vulnerable Populations Walking active control amnestic mild cognitive impairment arm base brain dysfunction brain health brain volume cerebral atrophy cognitive function cognitive performance cognitive testing design donepezil effective therapy executive function exercise intensity exercise intervention functional MRI scan gamma-Aminobutyric Acid improved improved functioning in vivo insight interdisciplinary approach lifestyle factors mild cognitive impairment neurobiological mechanism neuroimaging novel strategies post intervention pre-clinical primary outcome public health intervention public health relevance recruit relating to nervous system remediation secondary outcome sedentary sobriety treadmill

项目摘要

DESCRIPTION (provided by applicant): This is the revised application NIH R01-AG046928-01, titled "Effects of physical activity on brain function and network connectivity in MCI." The overall goal of this project is to assess the effect of physical activity on remediating early impairments in brain function in sedentary older adults at risk for Alzheimer's disease (AD). AD is the most common cause of cognitive impairment in older adults. The need for effective treatments has become imperative, as 36 million people worldwide are affected and counting. The results from several large pharmacological trials have been sobering with a lack of significant clinical outcomes, prompting a paradigm shift to initiate treatment earlier in the disease process and explore non-pharmacological interventions. Physical activity has recently emerged as a promising intervention for delaying disease onset and slowing cognitive decline in AD. However, the effect of physical activity on neurobiological mechanisms of action, such as brain activity and network function in at risk older adults with mild cognitive impairment (MCI), a preclinical stage of AD, remains largely unexplored. Thus, there is a need for well-designed randomized controlled trials (RCT) examining functional brain health outcomes of physical activity intervention in this vulnerable population. The objective of this proposal is to evaluate physical activity as an intervention for improving functional brain health by remediating hippocampal dysfunction and enhancing functional network connectivity in MCI. Using a unique interdisciplinary approach of modern neuroscientific methodology in an RCT, a comprehensive set of outcomes will be evaluated. This project will recruit 90 sedentary participants between 50-85 years of age with amnestic MCI. Consistent with the current Surgeon General's recommendation on moderate-intensity exercise, participants will be randomly assigned to one of three home-based groups for a 6-month intervention period: 1) aerobic walking for 150 mins/week, 2) stretching active-control for 150 mins/week, and 3) health education non-active control, with 30 participants in each group. We will examine the effects of physical activity on th primary neuroimaging outcomes of regional BOLD activity in the hippocampal, functional connectivity between the prefrontal cortex and hippocampus, and intrinsic connectivity of the default mode and executive networks. Additionally, we will examine secondary outcomes of brain volume, cognition, function, and serum biomarkers associated with physical activity. The effect of regional AD pathology on change in the outcome measures will be examined using amyloid PET.

描述（由申请人提供）：这是修订的应用程序NIH R01-AG046928-01，标题为“体育活动对MCI中脑功能和网络连接的影响”。该项目的总体目标是评估体育活动对久坐的老年人的脑功能障碍的疗法的影响，患有阿尔茨海默氏病风险（AD）。 AD是老年人认知障碍的最常见原因。有效治疗的需求已成为当务之急，因为全世界有3600万人受到影响和计数。几项大型药理学试验的结果一直在醒目，缺乏明显的临床结果，促使范式转移以在疾病过程中早期开始治疗并探索非药物学干预措施。最近，体育活动已成为一种有希望的干预措施，用于延迟疾病发作和减缓AD的认知能力下降。但是，体育活动对神经生物学机制的影响，例如大脑活动和网络功能，在患有轻度认知障碍的老年人（MCI）的风险中，A AD的临床前阶段仍然没有探索。因此，需要精心设计的随机对照试验（RCT）检查该脆弱人群中体育活动干预的功能性大脑健康结果。该提案的目的是通过修复海马功能障碍并增强MCI中的功能网络连接来评估体育活动作为改善功能性大脑健康的干预措施。将使用RCT中现代神经科学方法的独特跨学科方法，评估一组全面的结果。该项目将与Amnestic MCI一起招募90名久坐的参与者。与现任外科医生关于中等强度运动的建议一致，参与者将在6个月的干预期内随机分配给三个家庭基础组之一：1）有氧运动/周，每周150分钟，2）将活动性控制伸展150分钟/周和3）每个组的健康教育与30个参与者，每个组的参与者。我们将研究体育活动对海马的主要神经成像结果的影响，在海马，前额叶皮层和海马之间的功能连接以及默认模式和执行网络的固有连通性。此外，我们将研究与体育活动相关的大脑体积，认知，功能和血清生物标志物的次要结果。区域AD病理学对结果措施变化的影响将使用淀粉样蛋白PET检查。