Clinical and Translational Science Institute at Childrens National

国家儿童医院临床与转化科学研究所

• 批准号: 9534792
• 负责人: LISA MARIE GUAY-WOODFORD
• 金额: $ 514.83万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9534792
• 关键词: Address; Adult; Area; Caring; Child; Child Health; Childhood; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Integration; Development; Devices; Disease; Diverse Workforce; Ethics; Evaluation; Family; Generations; Genetic Diseases; Goals; Health; Health system; Home environment; Human; Institute of Medicine (U.S.); Institutes; Leadership; Link; Longevity; Mentors; Methods; Mission; Outcome; Pediatric Research; Population; Positioning Attribute; Process; Quality of life; Reporting; Research; Research Infrastructure; Research Personnel; Science; Services; Site; Technology; Training; Translational Research; Translations; Universities; Virginia; Vision; Washington; Workforce Development; catalyst; clinical practice; cost effective; design; disease heterogeneity; health application; improved; innovation; inter-institutional; multidisciplinary; novel; programs; translational pipeline; treatment strategy

OVERALL: PROJECT ABSTRACT Although children comprise one-quarter of the US population, only 10% of ClinicalTrials.gov registered studies focus on child health-related clinical and translational research (CTR). The mission of the Clinical and Translational Science Institute at Children's National (CTSI-CN) is to address the barriers and serve as a hub within the CTSA Network that is focused on the promotion of child health CTR. Established in 2010, the inaugural CTSI-CN (CTSI-CN v1.0) was organized as a collaboration between Children's National Health System (CNHS) and its academic partner, The George Washington University (GW). Over the past four years, CTSI-CN v1.0 has positioned itself as an effective catalyst for child-health CTR around four major themes: 1) improving the health of children and their families; 2) developing novel treatment strategies for rare genetic diseases; 3) designing new devices for pediatric care; and 4) characterizing childhood precursors of disease along the lifespan. We have embraced many of the tenets recommended in the July 2013 Institute of Medicine (IOM) report, specifically, developing multidisciplinary teams, providing cost-effective services and support for investigators, and streamlining processes that impact the effective conduct of CTR. The CTSI-CN is acknowledged locally as the hub for effective, high quality child health CTR and as a nurturing, integrated home for CTR team science. Nationally, the CTSI-CN has provided leadership in child health CTR, in both CTSA- and non-CTSA-linked consortia and steering committees. In the current proposal (CTSI-CN v2.0), we will continue to advance our vision and mission through innovative approaches and enhanced capabilities in our strategic themes. To this end, we have expanded our partnership to include Virginia Tech (VT) and its clinical partner, the Carilion Clinic. The goals of CTSI-CN v2.0, which will build on our established strengths, the lessons learned in CTSI-CN v1.0, and our new partnership with VT/Carilion (VTC), will also address the four NCATS strategic themes by: 1) developing a new generation of diverse, high quality child health-focused CTR investigators through innovative, inter-institutional educational, training, and mentoring programs (WORKFORCE DEVELOPMENT); 2) creating innovative approaches and technologies to catalyze CTR, particularly in child-health, through novel cross-disciplinary and inter-institutional collaborations with multiple stakeholder communities (COLLABORATION AND ENGAGEMENT); 3) catalyzing the development, dissemination and evaluation of novel methods to enhance translational science, with a particular emphasis on the child-health CTR spectrum (METHODS AND PROCESSES); 4) enhancing quality and efficiency across the translational spectrum through a) the integration of a high quality diverse workforce, b) implementation of new methods and processes, and c) collaboration among the institutional partners and communities (INTEGRATION): and 5) providing leadership within the CTSA Network through multi-site collaborations and educational programs, with a particular emphasis on child-health CTR and outcomes (CTSA NETWORK).

总体：项目摘要 尽管儿童占美国人口的四分之一，但只有10％的临床研究。 专注于与儿童健康相关的临床和转化研究（CTR）。临床和 儿童国家（CTSI-CN）的转化科学研究所将解决障碍并充当枢纽 在CTSA网络中，重点是促进儿童健康CTR。成立于2010年， 首届CTSI-CN（CTSI-CN V1.0）是在儿童国家健康之间的合作组织 系统（CNHS）及其学术合作伙伴乔治华盛顿大学（GW）。在过去的四年中， CTSI-CN V1.0已将自己定位为四个主要主题的儿童健康CTR的有效催化剂：1） 改善儿童及其家人的健康； 2）制定稀有遗传的新型治疗策略 疾病； 3）设计新设备的小儿护理设备； 4）表征童年的疾病前体 沿着寿命。我们已经接受了2013年7月医学研究所推荐的许多宗旨 （IOM）特别是开发多学科团队的报告，提供具有成本效益的服务和支持 研究人员，并简化影响CTR有效行为的过程。 CTSI-CN是 在当地被认为是有效，高质量儿童健康CTR的枢纽，并被培养，整合 CTR团队科学的所在地。在全国范围内，CTSI-CN在儿童健康CTR方面都提供了领导 CTSA和非CTSA连接的财团和转向委员会。在当前的提案（CTSI-CN v2.0）中，我们 将通过创新的方法和增强能力来继续提高我们的愿景和使命 我们的战略主题。为此，我们将合作伙伴关系扩展到包括弗吉尼亚理工学院（VT）及其 Carilion诊所临床合作伙伴。 CTSI-CN v2.0的目标将以我们既定的优势， CTSI-CN V1.0中学到的教训以及我们与VT/Carilion（VTC）的新合作伙伴关系也将解决 四个NCAT的战略主题：1）开发新一代多样的，高质量的儿童健康 CTR调查人员通过创新，机构间的教育，培训和指导计划 （劳动力发展）； 2）创建创新的方法和技术来催化CTR， 特别是在儿童健康中，通过与多个的新颖跨学科和机构间合作 利益相关者社区（合作与参与）； 3）催化发展， 对增强转化科学的新方法的传播和评估，特别强调 儿童健康CTR频谱（方法和过程）； 4）提高整个质量和效率 通过a）融合高质量多样化的劳动力的翻译光谱，b）实施 新方法和流程以及c）机构合作伙伴和社区之间的合作 （集成）：5）通过多站点的合作在CTSA网络中提供领导 教育计划，特别着重于儿童健康CTR和成果（CTSA网络）。