Social networks, breast cancer treatment, and survival

社交网络、乳腺癌治疗和生存

• 批准号: 9756142
• 负责人: CANDYCE H KROENKE
• 金额: $ 16.62万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756142
• 关键词: Adherence; Adjuvant; Advanced Malignant Neoplasm; Affect; Award; Behavior Therapy; Breast Cancer Patient; Breast Cancer Treatment; Breast Cancer survivor; Cancer Prognosis; Characteristics; Clinical; Clinical Treatment; Computerized Medical Record; Conflict (Psychology); Data; Data Collection; Data Set; Development; Diagnosis; Documentation; Environment; Epidemiologist; Epidemiology; Evaluation; Exercise; Foundations; Funding; Goals; Health; Healthcare Systems; Healthy People 2020; Individual; Internet; Intervention; K-Series Research Career Programs; Knowledge; Life Style; Linear Regressions; Literature; Longitudinal cohort; Malignant Neoplasms; Measurement; Measures; Medical center; Mentors; Methodology; Methods; Newly Diagnosed; Outcome; Pathway Analysis; Pathway interactions; Patients; Physical activity; Physicians; Positive Lymph Node; Psychosocial Factor; Questionnaires; Research; Research Personnel; Resources; Risk; Role; Smoking; Social Environment; Social Network; Social Psychology; Social support; Spouses; Structure; System; Testing; Time; Training; Translating; Treatment outcome; Variant; Woman; Women' s Health; Work; behavior change; behavioral outcome; breast cancer survival; cancer care; cancer recurrence; cancer survival; cancer therapy; career; career development; chemotherapy; clinical care; clinical development; clinical practice; clinically relevant; cohort; density; diabetic; hormone therapy; improved; improved outcome; individual patient; insight; interest; lifestyle factors; malignant breast neoplasm; meetings; member; mortality; multidisciplinary; multilevel analysis; outcome forecast; practical application; public health relevance; skill acquisition; skills; social; success; survival outcome; survival prediction; symposium; theories; treatment adherence; treatment optimization; tumor

 DESCRIPTION (provided by applicant): Each year, more than 200,000 women are diagnosed with, and nearly 40,000 die from their breast cancer (BC). Previous literature shows that social determinants, such as social networks, the web of social relationships that surround an individual, have a major role in BC survival. However, the mechanisms through which social networks influence prognosis, particularly effects on BC treatment, are unknown. Also, there is currently no systematic way in clinical care to identify socially isolated BC patients to facilitat intervention. Dr. Kroenke's career goal is to become a multidisciplinary, independently funded academic researcher in the social environment and cancer outcomes, to determine points of leverage for augmenting social networks to optimize BC treatment and improve clinical outcomes. Career development goals are to develop knowledge and expertise in: 1) The social environment (including social network theory, measurement, and analysis); 2) The conduct of social network behavioral interventions; 3) Clinical BC treatment and the use of electronic medical records (EMR) in research; and 4) Professional research skills. Goals will be accomplished through work with an outstanding group of mentors; formal didactics; seminars; meetings; and conferences. Specific Aims (SA) include: 1) In the Pathways study, a large KPNC cohort of 4,505 BC survivors with extensive data on social factors and cancer treatment, evaluate associations of social networks and BC treatment; 2) Evaluate associations of social networks, BC recurrence and mortality and the extent to which treatment variation related to social networks explains associations with survival; and 3) Develop, pilot, evaluate, and refine a brief "social networks as a vital sign" (SVS) measure to be collected in BC patients at the KP Oakland Medical Center, for entry into the EMR. Linear regression and survival methods will be used to analyze associations with BC treatment including receipt of and time to treatment and adherence to adjuvant hormonal therapy, as well as survival outcomes. We expect that women with a greater degree of supportive ties, and greater density, strength, and diversity of ties, wil have earlier, and better, adherence to treatment, and that treatment variations will help explain associations with survival. Findings from SA 1-2 and the proposed training will provide the foundation for developing the SVS measure in SA 3. The proposed study is the first to examine how social network structure influences BC treatment and survival. KPNC is an ideal environment for this career development award given strong mentors, institutional commitment, unique and extensive data on social factors and treatment, physician interests in improving patient social support, and opportunities for clinical intervention. Results from this study will b used to identify individual patients with compromised social networks within a large managed health care system and develop individual and system-level R-level social network interventions to optimize treatment and prognosis. Translating results to KP nationwide may improve outcomes in up to 20% of BC patients among the 10,000 incident BC cases diagnosed in KP each year.

 描述（由适用提供）：每年被诊断出20万多名妇女，并因其乳腺癌（BC）死亡近40,000名。先前的文献表明，社会决定者，例如社交网络，围绕个人的社会关系网络，在卑诗省生存中起着重要作用。但是，社交网络影响进展的机制，尤其是对卑诗省治疗的影响，尚不清楚。此外，目前尚无临床护理的系统方法来识别社会孤立的BC患者以识别干预措施。克罗恩克博士的职业目标是成为社会环境和癌症成果中的多学科，独立资助的学术研究人员，以确定增强社交网络以优化BC治疗并改善临床成果的杠杆率。职业发展目标是在以下方面发展知识和专业知识：1）社会环境（包括社会网络理论，测量和分析）； 2）社交网络行为干预的行为； 3）在研究中临床卑诗省治疗和电子病历（EMR）的使用； 4）专业研究技能。目标将通过与出色的导师团体的工作来实现；正式的教学学；半人物；会议；和会议。具体目的（SA）包括：1）在途径研究中，大型KPNC队列拥有4,505 BC幸存的生存，并具有有关社会因素和癌症治疗的广泛数据，评估了社交网络和卑诗省治疗的关联； 2）评估社交网络，卑诗省复发和死亡率的关联，以及与社交网络有关的治疗变异的程度解释了与生存的关联； 3）开发，开发，评估和完善简短的“社交网络作为生命体征”（SVS）措施，将在KP Oakland Medical Center的BC患者中收集，以进入EMR。线性回归和生存方法将用于分析与BC治疗的关联，包括收到和时间的治疗时间和依从性辅助荷尔蒙治疗以及生存结果。我们期望具有更大程度的支持关系，更大的密度，力量和关系多样性的妇女会更早，更好地遵守治疗，并且治疗差异将有助于解释与生存的关联。 SA 1-2和拟议培训的结果将为开发SA 3中的SVS测量的基础。拟议的研究是第一个研究社交网络结构如何影响BC治疗和生存的研究。 KPNC是该职业发展奖的理想环境，鉴于强大的导师，机构承诺，有关社会因素和治疗的独特和广泛数据，改善患者社会支持方面的身体兴趣以及临床干预的机会。这项研究的结果B将用于识别大型托管医疗保健系统中社交网络受损的个别患者，并开发个人和系统级的R级社交网络干预措施，以优化治疗和预后。在全国范围内将结果转换为KP，可以在每年诊断为KP的10,000例BC病例中，最多可以改善20％的卑诗省患者的预后。

项目成果

Antidepressant Use and Risk of Colorectal Cancer in the Women's Health Initiative.

• DOI: 10.1158/1055-9965.epi-17-1035
• 发表时间: 2018-08
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Kiridly-Calderbank JF;Sturgeon SR;Kroenke CH;Reeves KW
• 通讯作者: Reeves KW

Does the Hispanic Mortality Advantage Vary by Marital Status Among Postmenopausal Women in the Women's Health Initiative?

• DOI: 10.1093/abm/kaaa113
• 发表时间: 2021-01-15
• 期刊: ANNALS OF BEHAVIORAL MEDICINE
• 影响因子: 3.8
• 作者: Flores, Melissa;Ruiz, John M.;Thomson, Cynthia A.
• 通讯作者: Thomson, Cynthia A.

Evaluation of approaches to recruitment of racially and ethnically diverse breast cancer patients from an integrated health care setting for collection of observational social network data.

• DOI: 10.1007/s10552-023-01709-8
• 发表时间: 2023-08
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Kroenke, Candyce H.;Kurtovich, Elaine;Aoki, Rhonda;Shim, Veronica C.;Chan, Tracy D.;Brenman, Leslie Manace;Bethard-Tracy, Jane;Adams, Alyce S.;Kennedy, David P.
• 通讯作者: Kennedy, David P.

Egocentric social networks, lifestyle behaviors, and body size in the Asian Community Health Initiative (CHI) cohort.

亚洲社区健康倡议 (CHI) 队列中以自我为中心的社交网络、生活方式行为和体型。

• DOI: 10.1371/journal.pone.0232239
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kroenke,CandyceH;Le,GemM;Conroy,ShannonM;Canchola,AlisonJ;Shariff-Marco,Salma;Gomez,ScarlettLin
• 通讯作者: Gomez,ScarlettLin

A descriptive pilot study of structural and functional social network ties among women in the women's health initiative (WHI) study.

在妇女健康倡议 (WHI) 研究中，对妇女之间的结构性和功能性社交网络关系进行了描述性试点研究。

• DOI: 10.1080/08952841.2019.1608138
• 发表时间: 2021
• 期刊: Journal of women & aging
• 影响因子: 1.5
• 作者: Cené,CrystalW;Frerichs,Leah;Evans,JoshuaK;Kroenke,CandyceH;Dilworth-Anderson,Peggye;Corbie-Smith,Giselle;Snively,Beverly;Naughton,MichelleJ;Shumaker,Sally
• 通讯作者: Shumaker,Sally