Profilin as a target to suppress Invasive breast cancer

Profilin 作为抑制侵袭性乳腺癌的靶标

基本信息

批准号：
8462922
负责人：
PARTHA ROY
金额：
$ 26.45万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-12 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8462922
关键词：
1-Phosphatidylinositol 3-Kinase Actin-Binding Protein Actins Adenocarcinoma Affect Animals Behavior Binding Binding Proteins Biological Assay Breast Cancer Cell Cancer Patient Cells Cessation of life Clinical Cytoskeletal Proteins Cytoskeleton Cytosol Down-Regulation Family Figs - dietary Fluorescence Fluorescence Resonance Energy Transfer Funding Future Goals Histopathology In Vitro Knowledge Lead Life Link Malignant - descriptor Malignant Neoplasms Mammary Neoplasms Mammary gland Mediating Membrane Molecular Mus Neoplasm Metastasis Oncogenes Outcome Pathway interactions Patients Phosphatidylinositols Physiological Play Prognostic Marker Proteins Proto-Oncogene Proteins c-akt Regulation Research Role Signal Transduction Spectrum Analysis Staging Testing Therapeutic Time Tumor Cell Biology Tumor Cell Invasion United States Up-Regulation Woman arm cell motility cellular imaging cohort gain of function genetic regulatory protein in vivo insight intravital imaging malignant breast neoplasm mouse model neoplastic cell novel phosphoinositide-3,4,5-triphosphate phosphoinositide-3,4-bisphosphate polymerization profilin profilin 1 tumor tumor progression vasodilator-stimulated phosphoprotein

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed project is to investigate the functional significance of profilin-1 (Pfn1 - a cytoskeleton regulatory protein) downregulation in breast cancer. We will study how Pfn1, a traditionally pro- migratory molecule, can also regulate intracellular signaling generated at the membrane-cytosol interface to suppress breast cancer invasion and metastasis. In Aim 1, we will first combine clinical correlation and mouse model studies to determine whether a) there is a casual relationship between Pfn1 dysregulation and metastatic progression of breast cancer, and b) Pfn1 expression reflects stages in tumor progression and predicts clinical outcome of breast cancer patients (Aim 1). In Aims 2 and 3, we will identify the molecular pathways by which Pfn1 inhibits breast cancer dissemination Successful completion of these studies will determine whether Pfn1 could be used as a prognostic marker in breast cancer and justify novel cancer therapeutics revolving around Pfn1.

描述（由申请人提供）：拟议项目的总体目标是研究 profilin-1（Pfn1 - 一种细胞骨架调节蛋白）下调在乳腺癌中的功能意义。我们将研究Pfn1（一种传统的促迁移分子）如何调节膜-细胞质界面产生的细胞内信号传导，从而抑制乳腺癌的侵袭和转移。在目标 1 中，我们将首先结合临床相关性和小鼠模型研究，以确定 a) Pfn1 失调与乳腺癌转移进展之间是否存在因果关系，b) Pfn1 表达反映肿瘤进展阶段并预测乳腺癌的临床结果癌症患者（目标 1）。在目标 2 和 3 中，我们将确定 Pfn1 抑制乳腺癌扩散的分子途径。这些研究的成功完成将确定 Pfn1 是否可以用作乳腺癌的预后标志物，并证明围绕 Pfn1 的新型癌症疗法的合理性。