Inflammation and Pathogenesis Training Program

炎症与发病机制培训计划

• 批准号: 9753922
• 负责人: NEJAT K EGILMEZ
• 金额: $ 13.98万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753922
• 关键词: Inflammation; Pathogenesis; Training Programs

Abstract The major objective of this new training program is to produce skilled, rigorous, and creative scientists who will make novel connections between inflammatory processes and human pathogenesis. The University of Louisville is well-positioned to have high impact by selecting trainees with leadership potential from its existing Integrated Programs in Biomedical Sciences (IPIBS) for continued training on research topics that bridge microbiology and immunology. This interdisciplinary approach will bring together 35 faculty who are all highly productive scientists with extensive mentoring experience, and well-funded research programs, focused on i) inflammatory ontogeny and immune surveillance of cancer, ii) mechanisms of autoimmune disorders, iii) cellular and molecular mechanisms of host-microbial interactions, iv) animal models of infectious disease, v) the role of the microbiota in regulation of inflammatory diseases, vi) polymicrobial communities and inflammation, and vii) inflammation-driven disease and its impact on host physiology. Pre-candidacy support from IPIBS, in which all students receive stipends and benefits funded by the University of Louisville, includes laboratory rotations, advanced didactic training in immunology; inflammation; microbiology; and pathogenesis. Pre-candidacy training also includes research survival skills, including grant development and composition, oral presentations, scientific writing and publishing, professional networking, along with extensive training in the responsible conduct of research. To attain the highest positive peer-to-peer impact, each year two students who have demonstrated exceptional performance while successfully completing their first two years of graduate education as IPIBS Fellows, will be selected for two years of support from the T32 training grant. Students from diverse backgrounds who show the most potential, based on their achievements as IPIBS Fellows in graduate coursework, a qualifying exam, and in their research projects, will be selected in order to foster their academic leadership skills and excellence as research scientists. This additional training will occur through student organization of a program-specific discussion club, hosting two high profile speakers per year in disciplines that highlight important relationships between inflammation and pathogenesis and rigorous review of their research progress by a training mentor and dissertation committee. The program will be overseen by two Directors working closely with a Steering Committee, including an independent evaluation of the training program’s organization, leadership, objectives and outcomes by Internal and External Advisory Committees.

抽象的 这一新培训计划的主要目标是培养技术精湛、严谨且富有创造力的科学家，他们将 在炎症过程和人类发病机制之间建立新的联系。 路易斯维尔处于有利位置，可以通过从现有的学生中挑选具有领导潜力的学员来产生巨大影响 生物医学综合项目 (IPIBS)，用于继续培训研究主题 这种跨学科方法将汇集 35 名具有高度专业知识的教师。 富有成效的科学家，拥有丰富的指导经验和资金充足的研究项目，重点关注 i) 癌症的炎症个体发育和免疫监视，ii) 自身免疫性疾病的机制，iii) 宿主-微生物相互作用的细胞和分子机制，iv) 传染病动物模型，v) 微生物群在调节炎症性疾病中的作用，vi) 多种微生物群落和 炎症，和 vii) 炎症驱动的疾病及其对宿主生理学的影响。 来自 IPIBS，所有学生均获得路易斯维尔大学资助的津贴和福利，包括 实验室轮转、免疫学高级教学培训； 候选前培训还包括研究生存技能，包括拨款开发和组成， 口头报告、科学写作和出版、专业网络以及广泛的培训 为了实现最高的积极的同行影响，每年有两名学生进行研究。 他们在成功完成头两年的学习的同时表现出了出色的表现 作为 IPIBS 研究员的研究生教育将被选拔获得 T32 培训补助金的两年支持。 根据 IPIBS 的成就，来自不同背景、表现出最大潜力的学生 研究生课程、资格考试和研究项目的研究员将被选拔，以便 这项额外的培训将培养他们作为研究科学家的学术领导技能和卓越能力。 通过学生组织特定课程的讨论俱乐部，每年接待两位知名演讲者 在强调炎症与发病机制之间的重要关系和严格的学科中 该计划将由培训导师和论文委员会审查他们的研究进展。 由两名与指导委员会密切合作的董事监督，包括对 内部和外部咨询的培训计划的组织、领导、目标和成果 委员会。