FASEB SRC on Protein Aggregation, from Structural Variants to in Vivo Sequela

FASEB SRC 关于蛋白质聚集，从结构变异到体内后遗症

基本信息

批准号：
9752814
负责人：
Christina Sigurdson
金额：
$ 1.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9752814
关键词：
Address Affect Aging Alzheimer&apos s Disease Amyloid Amyloid Fibrils Amyotrophic Lateral Sclerosis Automobile Driving Biological Phenomena Biophysical Process Biophysics Cell physiology Characteristics Chemicals Clinical Collaborations Consensus Development Diagnosis Diagnostic Disease Economic Burden Environment Explosion Goals Human Pathology Huntington Disease In Vitro Individual Link Liquid substance Molecular Molecular Conformation Mutation Nature Nerve Degeneration Neurodegenerative Disorders Non-Insulin-Dependent Diabetes Mellitus Organelles Outcome Parkinson Disease Participant Pathology Phase Polymers Prevention strategy Primary Lateral Sclerosis Prion Diseases Prions Process Property Proteins Published Comment RNA-Binding Protein FUS Regulation Research Research Personnel Role Science Scientific Advances and Accomplishments Scientist Series Solid Structure System Systemic disease Therapeutic Time Variant amyloid fibril formation amyloid formation beta pleated sheet biological systems cell behavior cytotoxic disease phenotype driving force effective therapy extracellular in vivo innovation insight interest lens meetings nervous system disorder new technology novel strategies prion-like programs protein aggregation protein misfolding response self assembly summer research symposium synucleinopathy

项目摘要

Project summary Protein aggregation is a key feature associated with a wide range of neurological and systemic diseases of aging, yet the molecular mechanisms, precise role in disease, and therapy to inhibit or reverse aggregate formation remain poorly understood. Recent discoveries have shown that protein aggregation and self- assembly may be a key component of normal cellular organization and regulation, raising the question of how these ‘functional assembly’ processes are controlled, and why disease-related aggregation is not alleviated in the same way. This R13 proposal seeks core support for a FASEB Summer Research Conference on “Protein Aggregation, from Structural Variants to In Vivo Sequela”. The twelfth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to protein aggregation and assembly with the goal of ultimately intervening in these processes. The conference will be held in Snowmass, CO, on June 9th-14th, 2019, and will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on aggregation and self-assembly in both normal cellular function and disease provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.

项目摘要蛋白质聚集是与广泛的神经和全身性疾病相关的关键特征衰老，但分子机制，在疾病中的精确作用以及抑制或反向骨料的治疗形成仍然很少了解。最近的发现表明蛋白质聚集和自我组装可能是正常蜂窝组织和调节的关键组成部分，提出了一个问题这些“功能组装”过程受到控制，以及为什么与疾病相关的聚集没有缓解同样的方式。该R13提案为FaseB夏季研究会议寻求核心支持“蛋白质从结构变体到体内续集”。 1995年，我们的计划旨在利用可用于进步的蛋白质，系统和方法的广度我们对与蛋白质聚集和组装相关的各种生物学现象的理解最终干预这些过程的目标。会议将于6月在科罗拉多州雪摩斯举行 2019年9月至14日，将提供一个论坛，以介绍和讨论新出现的进步和讨论建立协作关系以应对该领域的巨大挑战。小尺寸（通常这次会议的150名参与者及其对全面研究的创新代表正常细胞功能和疾病中的聚集和自组装为捕获并整合了此过程的复杂性，并协同促进该领域。